公开(公告)号：AU2381695A

公开(公告)日：1995-11-29

申请号：AU2381695

申请日：1995-05-02

Applicant: GLAXO INC

Inventor： FANG FRANCIS GERARD ,  LOWERY MELISSA WILLIAMS ,  XIE SHIPING

IPC: A62D3/00 ,  A61K31/00 ,  A61K31/495 ,  A61P35/00 ,  B01J31/28 ,  C07B61/00 ,  C07D213/64 ,  C07D213/69 ,  C07D213/71 ,  C07D491/04 ,  C07D491/052 ,  C07D491/056 ,  C07D491/22 ,  C07D519/00

Abstract: The present invention relates to a method for preparing intermediates useful in the preparation of camptothecin and camptothecin-like compounds and to the intermediates used in this preparation. In particular, the invention provides a process for the preparation of a compound of formula II' wherein X is halogen, which comprises reacting a compound of formula III with a compound of formula IX'