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    N-PHENYL-N-(4-PIPERIDINYL)AMIDES, A PROCESS OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
    1.
    发明专利
    N-PHENYL-N-(4-PIPERIDINYL)AMIDES, A PROCESS OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM 未知

    公开(公告)号：CZ402591A3

    公开(公告)日：1993-04-14

    申请号：CS402591

    申请日：1991-12-23

    Applicant: GLAXO INC

    Inventor： FELDMAN PAUL L ,  BRACKEEN MARCUS F ,  LEIGHTON HARRY JEFFERSON ,  JAMES MICHAEL K ,  JOHNSON MICHAEL ROSS

    IPC: A61K20060101 ,  A61K31/445 ,  A61K31/4465 ,  A61P25/04 ,  C07B57/00 ,  C07D20060101 ,  C07D211/14 ,  C07D211/58

    Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I). wherein: X is a member selected from the group consisting of: alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C1-2)alkoxy-(C1-2)alkoxy-carbonyl-lower alkyl. Ar is a member selected from the group consisting of phenyl, mono-, di- and tri-substituted phenyl, wherein each subtitutuent is independently selected from the group consisting of halo, lower alkyl, lower alkoxy and trifluoromethyl; R is a member selected from the group consisting of lower alkyl, and lower alkoxy-lower alkyl; R is a member selected from the group consisting of hydrogen, lower alkoxy-carbonyl, and methoxymethyl; and R is a member selected from the group consisting of hydrogen and methyl; and the diastereomeric and enantiomeric isomers thereof, and the acid addition salts of said compounds and isomers. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

    2.
    发明专利
    未知

    公开(公告)号：MX9203024A

    公开(公告)日：1992-07-01

    申请号：MX9203024

    申请日：1992-06-19

    Applicant: GLAXO INC

    Inventor： FEELDMAN PAUL L ,  BRACKEEN MARKUS F ,  LEIGHTON HARRY JEFFERSON ,  JOHNSON MICHAEL ROSS

    IPC: A61K20060101 ,  A61K31/445 ,  A61K31/4465 ,  A61P25/04 ,  C07B57/00 ,  C07D20060101 ,  C07D211/14 ,  C07D211/58 ,  C07D213/643

    Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I). wherein: X is a member selected from the group consisting of: alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C1-2)alkoxy-(C1-2)alkoxy-carbonyl-lower alkyl. Ar is a member selected from the group consisting of phenyl, mono-, di- and tri-substituted phenyl, wherein each subtitutuent is independently selected from the group consisting of halo, lower alkyl, lower alkoxy and trifluoromethyl; R is a member selected from the group consisting of lower alkyl, and lower alkoxy-lower alkyl; R is a member selected from the group consisting of hydrogen, lower alkoxy-carbonyl, and methoxymethyl; and R is a member selected from the group consisting of hydrogen and methyl; and the diastereomeric and enantiomeric isomers thereof, and the acid addition salts of said compounds and isomers. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

    N-Phenyl-N-(4-piperidinyl)amides useful as analgesics
    4.
    发明专利
    N-Phenyl-N-(4-piperidinyl)amides useful as analgesics 未知

    公开(公告)号：IE77156B1

    公开(公告)日：1997-12-03

    申请号：IE53290

    申请日：1990-02-14

    Applicant: GLAXO INC

    Inventor： FELDMAN PAUL L ,  BRACKEEN MARCUS F ,  LEIGHTON HARRY JEFFERSON ,  JAMES MICHAEL K ,  JOHNSON MICHAEL ROSS

    IPC: A61K20060101 ,  A61K31/445 ,  A61K31/4465 ,  A61P25/04 ,  C07B57/00 ,  C07D20060101 ,  C07D211/14 ,  C07D211/58 ,  C07D211/66

    Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I). wherein: X is a member selected from the group consisting of: alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C1-2)alkoxy-(C1-2)alkoxy-carbonyl-lower alkyl. Ar is a member selected from the group consisting of phenyl, mono-, di- and tri-substituted phenyl, wherein each subtitutuent is independently selected from the group consisting of halo, lower alkyl, lower alkoxy and trifluoromethyl; R is a member selected from the group consisting of lower alkyl, and lower alkoxy-lower alkyl; R is a member selected from the group consisting of hydrogen, lower alkoxy-carbonyl, and methoxymethyl; and R is a member selected from the group consisting of hydrogen and methyl; and the diastereomeric and enantiomeric isomers thereof, and the acid addition salts of said compounds and isomers. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

    5.
    发明专利
    未知

    公开(公告)号：PT93137B

    公开(公告)日：1996-02-29

    申请号：PT9313790

    申请日：1990-02-14

    Applicant: GLAXO INC

    Inventor： FELDMAN PAUL L ,  JAMES MICHAEL K ,  BRACKEEN MARCUS F ,  JOHNSON MICHAEL ROSS ,  LEIGHTON HARRY JEFFERSON

    IPC: A61K20060101 ,  A61K31/445 ,  A61K31/4465 ,  A61P25/04 ,  C07B57/00 ,  C07D20060101 ,  C07D211/14 ,  C07D211/58 ,  C07D211/66

    Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I). wherein: X is a member selected from the group consisting of: alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C1-2)alkoxy-(C1-2)alkoxy-carbonyl-lower alkyl. Ar is a member selected from the group consisting of phenyl, mono-, di- and tri-substituted phenyl, wherein each subtitutuent is independently selected from the group consisting of halo, lower alkyl, lower alkoxy and trifluoromethyl; R is a member selected from the group consisting of lower alkyl, and lower alkoxy-lower alkyl; R is a member selected from the group consisting of hydrogen, lower alkoxy-carbonyl, and methoxymethyl; and R is a member selected from the group consisting of hydrogen and methyl; and the diastereomeric and enantiomeric isomers thereof, and the acid addition salts of said compounds and isomers. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

    8.
    发明专利
    未知

    公开(公告)号：PT93137A

    公开(公告)日：1990-08-31

    申请号：PT9313790

    申请日：1990-02-14

    Applicant: GLAXO INC

    Inventor： FELDMAN PAUL L ,  JAMES MICHAEL K ,  BRACKEEN MARCUS F ,  JOHNSON MICHAEL ROSS ,  LEIGHTON HARRY JEFFERSON

    IPC: A61K20060101 ,  A61K31/445 ,  A61K31/4465 ,  A61P25/04 ,  C07B57/00 ,  C07D20060101 ,  C07D211/14 ,  C07D211/58

    Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I). wherein: X is a member selected from the group consisting of: alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C1-2)alkoxy-(C1-2)alkoxy-carbonyl-lower alkyl. Ar is a member selected from the group consisting of phenyl, mono-, di- and tri-substituted phenyl, wherein each subtitutuent is independently selected from the group consisting of halo, lower alkyl, lower alkoxy and trifluoromethyl; R is a member selected from the group consisting of lower alkyl, and lower alkoxy-lower alkyl; R is a member selected from the group consisting of hydrogen, lower alkoxy-carbonyl, and methoxymethyl; and R is a member selected from the group consisting of hydrogen and methyl; and the diastereomeric and enantiomeric isomers thereof, and the acid addition salts of said compounds and isomers. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

    N-PHENYL-N-(4-PIPERIDINYL)AMIDES, PHARMACEUTICAL COMPOSITIONSì (54) CONTAINING THEM AND THEIR USE
    9.
    发明专利
    N-PHENYL-N-(4-PIPERIDINYL)AMIDES, PHARMACEUTICAL COMPOSITIONSì (54) CONTAINING THEM AND THEIR USE 未知

    公开(公告)号：SK402591A3

    公开(公告)日：2000-09-12

    申请号：SK402591

    申请日：1991-12-23

    Applicant: GLAXO INC

    Inventor： FELDMAN PAUL L ,  BRACKEEN MARCUS F ,  LEIGHTON HARRY JEFFERSON ,  JAMES MICHAEL K ,  JOHNSON MICHAEL ROSS

    IPC: A61K20060101 ,  A61K31/445 ,  A61K31/4465 ,  A61P25/04 ,  C07B57/00 ,  C07D20060101 ,  C07D211/14 ,  C07D211/58 ,  C07D211/66

    Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I). wherein: X is a member selected from the group consisting of: alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C1-2)alkoxy-(C1-2)alkoxy-carbonyl-lower alkyl. Ar is a member selected from the group consisting of phenyl, mono-, di- and tri-substituted phenyl, wherein each subtitutuent is independently selected from the group consisting of halo, lower alkyl, lower alkoxy and trifluoromethyl; R is a member selected from the group consisting of lower alkyl, and lower alkoxy-lower alkyl; R is a member selected from the group consisting of hydrogen, lower alkoxy-carbonyl, and methoxymethyl; and R is a member selected from the group consisting of hydrogen and methyl; and the diastereomeric and enantiomeric isomers thereof, and the acid addition salts of said compounds and isomers. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

    N-PHENYL-N-(4-PIPERIDINYL)AMIDE DERIVATIVES; PREPARATORY PROCESSES AND PHARMACEUTICAL COMPOSITIONS
    10.
    发明专利
    N-PHENYL-N-(4-PIPERIDINYL)AMIDE DERIVATIVES; PREPARATORY PROCESSES AND PHARMACEUTICAL COMPOSITIONS 未知

    公开(公告)号：NZ232542A

    公开(公告)日：1992-06-25

    申请号：NZ23254290

    申请日：1990-02-14

    Applicant: GLAXO INC

    Inventor： FELDMAN PAUL L ,  BRACKEEN MARCUS F ,  LEIGHTON HARRY JEFFERSON ,  JAMES MICHAEL K ,  JOHNSON MICHAEL ROSS

    IPC: A61K20060101 ,  A61K31/445 ,  A61K31/4465 ,  A61P25/04 ,  C07B57/00 ,  C07D20060101 ,  C07D211/14 ,  C07D211/58 ,  C07D211/66

    Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I). wherein: X is a member selected from the group consisting of: alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C1-2)alkoxy-(C1-2)alkoxy-carbonyl-lower alkyl. Ar is a member selected from the group consisting of phenyl, mono-, di- and tri-substituted phenyl, wherein each subtitutuent is independently selected from the group consisting of halo, lower alkyl, lower alkoxy and trifluoromethyl; R is a member selected from the group consisting of lower alkyl, and lower alkoxy-lower alkyl; R is a member selected from the group consisting of hydrogen, lower alkoxy-carbonyl, and methoxymethyl; and R is a member selected from the group consisting of hydrogen and methyl; and the diastereomeric and enantiomeric isomers thereof, and the acid addition salts of said compounds and isomers. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

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