公开(公告)号：KR790000084B1

公开(公告)日：1979-03-12

申请号：KR720000155

申请日：1972-02-03

Applicant: GLAXO LAB LTD

Inventor： COOK M CH ,  GREGSON M ,  GORDON IAN GREGORY

IPC: A61K20060101 ,  C07D499/64 ,  C07D501/22 ,  C07D501/24

Abstract: 7β-acylamidoceph-3-em-4-carboxylic acids and 6β-acylamidopenam-3-carboxylic acid, and their alk. salts or acid salts, esters and sulfoxides with antibacterial activity and high stability to β-lactamase, were synthesized. 7-aminoceph-3-em-4-carboxylic acid or 6-aminopenam-3-carboxylic acid was related with acylating agent at -20-20≦̸C in the inactive inog. solvent to give syn- or anti- isomer, or the mixt. contg. more than 75% one isomer.

公开(公告)号：KR790000420B1

公开(公告)日：1979-05-14

申请号：KR740004319

申请日：1974-12-20

Applicant: GLAXO LAB LTD

Inventor： JANICE BRADSHAW ,  COOK M CH

Abstract: Non-toxic 7- acylamidoceph-3 em -4-carboxylic acid derivs. (I; R= thienyl, furyl, Ra=Rb=H, C1-4 alkyl, C2-4 alkenyl, C3-7 cycloalkyl, phenyl, thienyl, furyl, carboxy, C2-5 alkoxycarbonyl, cyano) of syn-isomer or syn-and anti-mixt. contg. >90% syn-isomer were manufd. Acylation for I was carried out at -20-30≦̸C in the reactive media such as methylene chloride, dimethlformamide or acetonitril. I showed broad spectral action, esp. to gram-negative bacteria.

公开(公告)号：KR790000340B1

公开(公告)日：1979-05-01

申请号：KR780002980

申请日：1978-09-29

Applicant: GLAXO LAB LTD

Inventor： MICLE GREGSON ,  COOK M CH

Abstract: Title compds. [I; R = H or org. group, Ra=H or acyl, B=S

公开(公告)号：KE2816A

公开(公告)日：1978-02-24

申请号：KE281678

申请日：1978-02-06

Applicant: GLAXO LAB LTD

Inventor： COOK M CH ,  BRADSHAW J ,  GREGORY G I

IPC: C07D501/32 ,  A61D7/00 ,  A61K20060101 ,  A61K31/43 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/06 ,  C07D501/24 ,  C07D501/26 ,  C07D501/28 ,  C07D501/34 ,  C07D501/60

公开(公告)号：HK17378A

公开(公告)日：1978-04-07

申请号：HK17378

申请日：1978-03-30

Applicant: GLAXO LAB LTD

Inventor： GREGORY G I ,  COOK M CH ,  BRADSHAW J

IPC: C07D501/32 ,  A61D7/00 ,  A61K20060101 ,  A61K31/43 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/06 ,  C07D501/24 ,  C07D501/26 ,  C07D501/28 ,  C07D501/34 ,  C07D501/60