公开(公告)号：US3830700A

公开(公告)日：1974-08-20

申请号：US29464972

申请日：1972-10-03

Applicant: GLAXO LAB LTD

Inventor： O CALLAGHAN C ,  KIRBY S ,  HEATH I ,  CLARK J ,  KENNEDY J ,  SHINGLER A ,  WEIR N ,  LONG A ,  MORRIS A

IPC: C07D501/22 ,  C07D501/24 ,  C12Q1/34 ,  C12K1/00 ,  G01N31/22

CPC classification number: C12Q1/34 ,  C12Q2334/00 ,  G01N2333/986 ,  G01N2415/00 ,  Y10S435/805

Abstract: WHERE R IS AMINO OR BLOCKED AMINO, X IS -S-, -SO(A OR B) OR -S2-, AND AR IS A CARBOCYCLE OR A HETEROCYCLE SUBSTITUTED BY AT LEAST ONE ELECTRON WITHDRAWING SUBSTITUENT IN CONJUGATION WITH THE EXOCYCLIC -CH=CHDOUBLE BOND,AND SALTS AND ESTERS ARE USEFUL CHROMOGENIC AGENTS FOR THE DETECTION OF B-LACTAMASE ACTIVITY. TEST REAGENTS CONTAINING SUCH COMPOUNDS ARE ALSO DISCLOSED.

1,2-(-C(-COOH)=C(-CH=CH-AR)-CH2-X-),3-R-AZETIDIN-4-ONE

CEPHALOSPORIN COMPOUNDS HAVING THE FORMULA