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    Esters of tetraiodoanthranilic acid
    5.
    发明授权
    Esters of tetraiodoanthranilic acid 失效
    四碘邻氨基苯甲酸酯

    公开(公告)号：US3218349A

    公开(公告)日：1965-11-16

    申请号：US26151763

    申请日：1963-02-27

    Applicant: GLAXO LAB LTD

    Inventor： HAROLD CHAPMAN JOHN ,  WILLIAM GRAHAM ,  MAJOR EVANS RONALD

    IPC: A61K49/04

    CPC classification number: A61K49/0433

    Abstract: The invention comprises compounds of the general formula (wherein R is a hydrogen atom, an inert cation or a C1-6 alkyl group), and the preparation of: (1) the free acid by reacting a hypobromite or hypochlorite with tetraiodophthalamic acid or a salt thereof, which may be made from ammonia and tetraiodophthalic anhydride; and (2) the esters above by esterifying tetraiodoanthranilic or a metal salt thereof. An "inert cation" is a cation that does not appreciably affect the pharmaceutical characteristics of the compound to which it is attached. According to the Provisional Specification, R, when an alkyl group, may be substituted by bromine or chlorine atoms, hydroxyl, alkoxy or nitro groups.ALSO:Broncographic compositions comprise a compound of the general formula (wherein R is a hydrogen atom, an inert cation or a C1-6 alkyl group) in an aqueous or oily liquid medium. They may be administered in any convenient way. An "inert cation" is a cation that does not appreciably affect the pharmaceutical characteristics of the compound to which it is attached. According to the Provisional Specification, R, when an alkyl group, may be substituted by bromine or chlorine atoms, hydroxyl, alkoxy or nitro groups.

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