公开(公告)号：US20150352229A1

公开(公告)日：2015-12-10

申请号：US14758493

申请日：2013-12-27

Applicant: GLUSENSE, LTD.

Inventor： Boaz BRILL ,  Itamar WEISMAN ,  Micha GLADNIKOFF

IPC: A61K49/00 ,  C12N5/00

CPC classification number: A61K49/0045 ,  A61B5/0071 ,  A61B5/14532 ,  A61B5/1459 ,  A61B2562/0233 ,  A61B2562/162 ,  C12N5/0068 ,  G01N33/54373 ,  G01N2500/10

Abstract: Apparatus is provided that contains cells for implantation into a human subject. The apparatus includes a substantially non-degradable three-dimensional scaffold having surfaces to which the cells are attached, and a hydrogel, which is attached to the cells. The scaffold, the cells, and the hydrogel are arranged such that the cells are sandwiched in spaces between the hydrogel and the surfaces of the scaffold, thereby allowing mobility and proliferation of the cells in the spaces between the hydrogel and the surfaces of the scaffold, and preventing the mobility and the proliferation of the cells to locations outside of the spaces between the hydrogel and the surfaces of the scaffold.

Abstract translation: 提供了包含用于植入人受试者的细胞的装置。 该装置包括具有连接细胞的表面的基本上不可降解的三维支架，以及附着于细胞的水凝胶。 布置支架，细胞和水凝胶，使得细胞夹在水凝胶和支架表面之间的空间中，从而允许细胞在水凝胶和支架表面之间的空间中的移动和增殖， 并且防止细胞迁移和增殖到水凝胶和支架表面之间的空间之外的位置。

公开(公告)号：US20170303838A1

公开(公告)日：2017-10-26

申请号：US15517318

申请日：2015-10-13

Applicant: GLUSENSE LTD.

Inventor： Boaz BRILL

IPC: A61B5/1455 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1459 ,  G01N21/64

CPC classification number: A61B5/14556 ,  A61B5/0071 ,  A61B5/14532 ,  A61B5/1459 ,  G01N21/6428 ,  G01N21/6456 ,  G01N2201/021

Abstract: An implantable unit includes fluorescent sensor molecules, each of which includes a binding site for an analyte, a donor fluorophore, and an acceptor fluorophore; and a first light source. An external system includes an external reading unit, which includes a light sensor; and a processor, which is configured to (i) during a first time period: (a) drive the first light source to generate light having a first illumination peak wavelength appropriate for excitation of the donor fluorophore, and (b) receive, from the light sensor, a first measurement of the fluorescent light emitted from the acceptor fluorophore, (ii) during a second time period: (a) drive a second light source to generate light having a second illumination peak wavelength appropriate for direct excitation of the acceptor fluorophore, and (b) receive, from the light sensor, a second measurement of the fluorescent light emitted from the acceptor fluorophore, and (iii) calculate the concentration of the analyte based on the measurements.

公开(公告)号：US20170100598A1

公开(公告)日：2017-04-13

申请号：US14881431

申请日：2015-10-13

Applicant: GLUSENSE LTD.

Inventor： Yossi GROSS ,  Boaz BRILL

IPC: A61N1/378 ,  A61M39/02 ,  H02J7/02

CPC classification number: A61N1/3787 ,  A61M5/14276 ,  A61M39/0208 ,  A61M2039/0238 ,  A61N1/3605

Abstract: An implant system includes an implant, which is configured to be implanted in a body of a subject, and an external controller. The external controller includes a wireless energy transmitter. The implant comprises a wireless energy receiver, which is configured to receive energy from the wireless energy transmitter; and one or more electrical light sources, which are (a) electrically coupled to the wireless energy receiver, and (b) configured to emit light upon being triggered by the wireless energy receiver receiving the energy from the wireless energy transmitter.

公开(公告)号：US20170072074A1

公开(公告)日：2017-03-16

申请号：US15360523

申请日：2016-11-23

Applicant: GLUSENSE LTD.

Inventor： Micha GLADNIKOFF ,  Boaz BRILL ,  Itamar WEISMAN

IPC: A61K49/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/00

CPC classification number: A61K49/0097 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14735 ,  A61B2562/0233 ,  A61B2562/162 ,  A61K49/0045

Abstract: Apparatus is provided for implantation of live cells in a subject. The apparatus includes an implantable immunoisolation device, which includes (a) a chamber, which contains the live cells; (b) an inner membrane layer, which is disposed at an external surface of the chamber, and which comprises a selective membrane that is permeable to nutrients; and (c) an outer hydrogel layer, which comprises a hydrogel, and which is attached to and coats an outer surface of the inner membrane layer. Other embodiments are also described.

Abstract translation: 提供了用于在受试者中植入活细胞的装置。 该装置包括可植入免疫隔离装置，其包括（a）包含活细胞的腔室; （b）内膜层，其设置在所述室的外表面，并且包括可渗透营养物质的选择性膜; 和（c）外部水凝胶层，其包含水凝胶，并且附着到外层表面并涂覆其内表面。 还描述了其它实施例。