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公开(公告)号：US20130092622A1
公开(公告)日：2013-04-18
申请号：US13436043
申请日：2012-03-30
Applicant: Onur Y. Kas , Mikhail Kozlov , Gabriel Tkacik , David Nhiem , Philip Goddard , Sherry Ashby Leon
Inventor： Onur Y. Kas , Mikhail Kozlov , Gabriel Tkacik , David Nhiem , Philip Goddard , Sherry Ashby Leon
IPC: B01D69/12
CPC classification number: B01D69/12 , B01D71/56 , B01D2323/39 , B01D2325/02 , D01D5/0084
Abstract: A composite liquid filtration platform including a composite filtration medium featuring an electrospun polymeric nanofiber layer collected on a porous membrane. When in use, the porous membrane acts as a prefilter used upstream from the polymeric nanofiber layer to remove particles from a liquid stream flowing through the composite filtration structure. The nanofiber layer, positioned downstream from the porous membrane, is used as the retentive layer for critical filtration to provide biosafety assurance, and is responsible for capturing microorganisms like bacteria, mycoplasma or viruses. The composite liquid filtration platform provided herein exhibits permeability advantages over conventional porous membranes or nanofiber mats spun on coarse non-wovens.
Abstract translation: 一种复合液体过滤平台，其包括复合过滤介质，其特征在于在多孔膜上收集的电纺聚合物纳米纤维层。 当使用时，多孔膜用作在聚合物纳米纤维层上游使用的预过滤器，以从流过复合过滤结构的液体流中除去颗粒。 位于多孔膜下游的纳米纤维层用作临界过滤的保留层，以提供生物安全保证，并负责捕获细菌，支原体或病毒等微生物。 本文提供的复合液体过滤平台相对于在粗糙无纺布上纺出的常规多孔膜或纳米纤维垫表现出渗透性优点。
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公开(公告)号：US20120076934A1
公开(公告)日：2012-03-29
申请号：US13312491
申请日：2011-12-06
Applicant: Gabriel Tkacik , Philip Goddard , Willem Kools , Nitin Satav
Inventor： Gabriel Tkacik , Philip Goddard , Willem Kools , Nitin Satav
CPC classification number: B01D69/12 , B01D61/145 , B01D67/0013 , B01D67/0016 , B01D67/0018 , B01D71/34 , B01D71/68 , B01D2323/12 , B01D2323/42 , B01D2325/022 , C07K1/34
Abstract: The present invention is an integral multilayered composite membrane having at least one ultrafiltration layer made by cocasting or sequentially casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a multilayered composite membrane having at least one ultrafiltration layer.
Abstract translation: 本发明是一种具有至少一个超滤层的整体式多层复合膜，该超滤层是通过将多种聚合物溶液共沉淀或依次浇注到载体上形成多层液体薄片并将该薄片浸入液体凝固浴中以进行相分离和形成 具有至少一个超滤层的多层复合膜。
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公开(公告)号：US5228994A
公开(公告)日：1993-07-20
申请号：US960047
申请日：1992-10-13
Applicant: Gabriel Tkacik , Andrew J. Bartlett
Inventor： Gabriel Tkacik , Andrew J. Bartlett
CPC classification number: B01D69/12
Abstract: A composite microporous membrane is provided having a microporous nonretentive substrate and a retentive microporous layer coated directly to the substrate in the absence of an intermediate support layer.
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公开(公告)号：US11154821B2
公开(公告)日：2021-10-26
申请号：US13436043
申请日：2012-03-30
Applicant: Onur Y. Kas , Mikhail Kozlov , Gabriel Tkacik , David Nhiem , Philip Goddard , Sherry A. Leon
Inventor： Onur Y. Kas , Mikhail Kozlov , Gabriel Tkacik , David Nhiem , Philip Goddard , Sherry A. Leon
Abstract: A composite liquid filtration platform including a composite filtration medium featuring an electrospun polymeric nanofiber layer collected on a porous membrane. When in use, the porous membrane acts as a prefilter used upstream from the polymeric nanofiber layer to remove particles from a liquid stream flowing through the composite filtration structure. The nanofiber layer, positioned downstream from the porous membrane, is used as the retentive layer for critical filtration to provide biosafety assurance, and is responsible for capturing microorganisms like bacteria, mycoplasma or viruses. The composite liquid filtration platform provided herein exhibits permeability advantages over conventional porous membranes or nanofiber mats spun on coarse non-wovens.
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5.发明授权Porous polymeric structures and a method of making such structures by means of heat-induced phase separation 失效多孔聚合物结构和通过热诱导相分离制备此类结构的方法
公开(公告)号：US5444097A
公开(公告)日：1995-08-22
申请号：US909904
申请日：1992-07-07
Applicant: Gabriel Tkacik
Inventor： Gabriel Tkacik
CPC classification number: B01D67/0018 , B01D67/003 , C08J9/28 , B01D2323/12 , C08J2201/0502 , C08J2201/052 , C08J2201/0542
Abstract: Porous polymeric structures are provided along with a method to make such structures comprising heat-induced phase separation of a polymeric solution exhibiting a lower critical solution temperature.
Abstract translation: 提供多孔聚合物结构以及制备这种结构的方法包括显示较低临界溶解温度的聚合物溶液的热诱导相分离。
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Patent Agency Ranking
公开(公告)号：US09010545B2
公开(公告)日：2015-04-21
申请号：US13312491
申请日：2011-12-06
Applicant: Gabriel Tkacik , Philip Goddard , Willem Kools , Nitin Satav
Inventor： Gabriel Tkacik , Philip Goddard , Willem Kools , Nitin Satav
CPC classification number: B01D69/12 , B01D61/145 , B01D67/0013 , B01D67/0016 , B01D67/0018 , B01D71/34 , B01D71/68 , B01D2323/12 , B01D2323/42 , B01D2325/022 , C07K1/34
Abstract: The present invention is an integral multilayered composite membrane having at least one ultrafiltration layer made by cocasting or sequentially casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a multilayered composite membrane having at least one ultrafiltration layer.
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7.发明授权Method and system for controlling pore size of microporous phase inversion membranes 有权用于控制微孔相转移膜孔径的方法和系统公开(公告)号：US07560024B2
公开(公告)日：2009-07-14
申请号：US10419492
申请日：2003-04-21
Applicant: Willem Franciscus Catherina Kools , Ronald Tuccelli , Gabriel Tkacik
Inventor： Willem Franciscus Catherina Kools , Ronald Tuccelli , Gabriel Tkacik
CPC classification number: G05D11/132 , B01D67/0009 , B01D67/0011 , B01D69/02 , B01D69/12 , B01D2323/12 , B01D2325/04 , B01F5/0413 , B01F5/0602 , B01F15/0429
Abstract: This invention provides for a method to control the pore size or bubble point of porous membranes made by phase inversion in a continuous manufacturing process by blending two or more solutions each capable of producing a porous membrane with different pore size or bubble point than the pore size or bubble point of the desired membrane, and blending these solutions by the method of this invention to produce the desired pore size or bubble point. This invention also provides for a method to monitor membrane pore size in a continuous process and adjust pore size during the continuous manufacturing process.
Abstract translation: 本发明提供一种通过混合两种或更多种溶液来控制在连续制造过程中通过相转化制备的多孔膜的孔径或泡点的方法，每种溶液能够产生具有不同孔径或泡点的多孔膜 或泡沫点，并通过本发明的方法将这些溶液混合以产生所需的孔径或泡点。 本发明还提供了在连续制造过程中监测连续过程中的膜孔径并调节孔径的方法。
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公开(公告)号：US07108791B2
公开(公告)日：2006-09-19
申请号：US10145939
申请日：2002-05-15
Applicant: Gabriel Tkacik , Greg Kazan
Inventor： Gabriel Tkacik , Greg Kazan
IPC: B01D61/00
CPC classification number: A61L2/0017 , A61L2/022 , B01D61/142 , B01D61/18 , B01D63/067 , B01D63/14 , B01D69/02 , B01D69/12 , B01D2313/44 , B01D2315/08
Abstract: The present invention provides a high-resolution membrane-based method for removing a virus from a manufactured protein-containing solution, the method being particularly characterized by its capacity to be performed quickly (i.e., as measured by flux) and efficiently (i.e., as measured by log reduction value, LRV). Towards such results, the present invention employs a plurality (i.e., greater than 2) of interfacially-contiguous asymmetric ultrafiltration membranes, the foremost of which is oriented with its “tight side” facing downstream. The present invention also provides a filtration capsule, useful in the conduct of the method, comprising a pleated tube formed of three interfacially-contiguous asymmetric ultrafiltration membranes.
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公开(公告)号：US20060060519A1
公开(公告)日：2006-03-23
申请号：US11268163
申请日：2005-11-07
Applicant: Gabriel Tkacik , Greg Kazan
Inventor： Gabriel Tkacik , Greg Kazan
IPC: B01D63/14
CPC classification number: A61L2/0017 , A61L2/022 , B01D61/142 , B01D61/18 , B01D63/067 , B01D63/14 , B01D69/02 , B01D69/12 , B01D2313/44 , B01D2315/08
Abstract: The present invention provides a high-resolution membrane-based method for removing a virus from a manufactured protein-containing solution, the method being particularly characterized by its capacity to be performed quickly (i.e., as measured by flux) and efficiently (i.e., as measured by log reduction value, LRV). Towards such results, the present invention employs a plurality (i.e., greater than 2) of interfacially-contiguous asymmetric ultrafiltration membranes, the foremost of which is oriented with its “tight side” facing downstream. The present invention also provides a filtration capsule, useful in the conduct of the method, comprising a pleated tube formed of three interfacially-contiguous asymmetric ultrafiltration membranes.
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公开(公告)号：US09750829B2
公开(公告)日：2017-09-05
申请号：US13257501
申请日：2010-03-19
Applicant: Mikhail Kozlov , Wilson Moya , Gabriel Tkacik
Inventor： Mikhail Kozlov , Wilson Moya , Gabriel Tkacik
CPC classification number: A61L2/0017 , B01D39/1623 , B01D67/0004 , B01D67/002 , B01D69/00 , B01D2239/025 , B01D2323/39 , C02F1/444 , C02F2303/04
Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
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