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    Haptotactic peptides
    1.
    发明授权
    Haptotactic peptides 失效
    抗体肽

    公开(公告)号：US07544655B2

    公开(公告)日：2009-06-09

    申请号：US11601024

    申请日：2006-11-17

    Applicant: Gerard Marx ,  Raphael Gorodetsky

    Inventor： Gerard Marx ,  Raphael Gorodetsky

    IPC: A61K38/10 ,  A61K38/00

    CPC classification number: A61K38/363 ,  C07K14/75

    Abstract: Novel cell attachment peptides having sequences homologous to specific portions of the carboxy terminal sequence of fibrinogen chains are disclosed. The novel peptides, derived from proteins related to fibrinogen including a peptide adjacent to fibrinogen γ-chain C terminus denoted pre-Cγ possess cell attraction activities, and are useful in pharmaceutical compositions.

    Abstract translation: 公开了具有与纤维蛋白原链的羧基末端序列的特定部分同源的序列的新型细胞附着肽。 衍生自与纤维蛋白原相关的蛋白质的新型肽包括邻近纤维蛋白原γ链C末端的肽，表示前Cgma具有细胞吸引活性，并且可用于药物组合物。

    Fibrin nanoparticles and uses thereof
    2.
    发明授权
    Fibrin nanoparticles and uses thereof 失效

    公开(公告)号：US06552172B2

    公开(公告)日：2003-04-22

    申请号：US09942984

    申请日：2001-08-30

    Applicant: Gerard Marx ,  Raphael Gorodetsky

    Inventor： Gerard Marx ,  Raphael Gorodetsky

    IPC: A61K3514

    CPC classification number: B82Y5/00 ,  C07K14/75 ,  Y10S977/773 ,  Y10S977/91

    Abstract: The present invention provides fibrin nanoparticles having a mean diameter of 200-2000 nm. The present invention provides also methods for preparing fibrin particles of various sizes, including fibrin nanoparticles and fibrin microbeads. The present invention further provides compositions comprising fibrin particles and an agent, wherein the agent is coupled to the amine or carboxy moieties on the surface of the fibrin particles. In addition the present invention provides a composition comprising fibrin nanoparticles and an agent, wherein the agent is admixed with the fibrin nanoparticles. Still further, the present invention provides a method for introducing an agent into a cell, a method for isolating stem and/or progenitor cells from a biological sample, as well as a composition comprising fibrin particles bound to stem and/or progenitor cells.

    Haptotactic peprides
    4.
    发明授权
    Haptotactic peprides 失效
    快餐胡椒粉

    公开(公告)号：US07148190B2

    公开(公告)日：2006-12-12

    申请号：US10181187

    申请日：2001-01-21

    Applicant: Gerard Marx ,  Raphael Gorodetsky

    Inventor： Gerard Marx ,  Raphael Gorodetsky

    IPC: C07K17/00 ,  C07K17/02 ,  A61K38/10 ,  A61K35/14

    CPC classification number: A61K38/363 ,  C07K14/75

    Abstract: We disclose haptotactic peptides having sequences homologous to specific portions of the carboxy terminal sequence of fibrinogen chains. The peptides derived from fibrinogen pre-Cγ chain possess activities of cell attraction or cell attachment to a surface to which the peptide is covalently bound.

    Abstract translation: 我们公开了具有与纤维蛋白原链的羧基末端序列的特定部分同源的序列的连接肽。 衍生自纤维蛋白原前Cgamma链的肽具有细胞吸引或细胞附着到肽共价结合的表面的活性。

    Biologic bioadhesive compositions containing fibrin glue and liposomes, methods of preparation and use
    6.
    发明授权
    Biologic bioadhesive compositions containing fibrin glue and liposomes, methods of preparation and use 失效
    含有纤维蛋白胶和脂质体的生物生物粘附剂组合物，制备和使用方法

    公开(公告)号：US5651982A

    公开(公告)日：1997-07-29

    申请号：US465888

    申请日：1995-06-06

    Applicant: Gerard Marx

    Inventor： Gerard Marx

    IPC: A61K9/127 ,  A61K38/43 ,  A61K47/42 ,  A61L24/00 ,  A61L24/04 ,  A61L24/10 ,  A61P7/04 ,  A61P17/02

    CPC classification number: A61L24/106 ,  A61K47/42 ,  A61K9/127 ,  A61L24/0015 ,  A61L24/043 ,  A61L2300/102 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/428 ,  A61L2300/626 ,  Y10T428/2984

    Abstract: The present invention describes a biologically compatible bioadhesive sealant composition comprising fibrin glue and liposomes for use in mammals, including humans. Fibrin glue of the invention comprises fibrinogen and thrombin which are mixed together in various modes with liposomes and applied to a site of injury, to a wound, or to a surgical or nonsurgical incision or opening. In accordance with the invention, the liposomes are embedded within the fibrin glue after coagulation has occurred, and may release bioactive substances contained within their aqueous interiors to promote healing and protection during the recovery process. The bioadhesive composition of the invention promises to maintain hemostasis after surgeries and improves upon existing glues or gel formulations due to its complete biological compatibility, its formation in situ, and its provision of bioactive therapeutics via entrapped liposomes directly to the site. Long-lasting biophysical and biomechanical properties as well as therapeutic value are imparted to the fibrin glue components by the liposome component of the composition. The biocompatible fibrin glue and liposome composition is also amenable for fabrication into films, coatings, or membranes for in vitro and in vivo uses.

    Abstract translation: 本发明描述了一种生物相容的生物粘附密封剂组合物，其包含用于哺乳动物（包括人）的纤维蛋白胶和脂质体。 本发明的纤维蛋白胶包含纤维蛋白原和凝血酶，其以各种模式与脂质体混合在一起并施加到损伤部位，伤口或手术或非手术切口或开口处。 根据本发明，在发生凝血后，脂质体被包埋在纤维蛋白胶中，并且可能释放其水性内部物质中包含的生物活性物质，以在恢复过程中促进愈合和保护。 本发明的生物粘合剂组合物有望在手术后保持止血，并且由于其完全的生物相容性，其原位形成以及通过截留的脂质体直接提供到生物活性治疗剂，而改进现有的胶或凝胶制剂。 通过组合物的脂质体组分将持久的生物物理和生物力学性质以及治疗价值赋予纤维蛋白胶组分。 生物相容性纤维蛋白胶和脂质体组合物也可用于制造用于体外和体内用途的膜，涂层或膜。

    Liposomal composition comprising haptotactic peptides
    7.
    发明申请
    Liposomal composition comprising haptotactic peptides 审中-公开
    包含触键肽的脂质体组合物

    公开(公告)号：US20070003480A1

    公开(公告)日：2007-01-04

    申请号：US10533826

    申请日：2003-11-03

    Applicant: Gerard Marx ,  Raphael Gorodetsky

    Inventor： Gerard Marx ,  Raphael Gorodetsky

    IPC: A61K51/00 ,  A61K39/395 ,  A61K49/10 ,  A61K9/127

    CPC classification number: A61K8/14 ,  A61K8/64 ,  A61K9/127 ,  A61K38/363 ,  A61K49/0002 ,  A61Q19/00

    Abstract: The present invention relates to liposomal composition comprising peptides characterized in that they elicit cell attachment (haptotactic) responses and are internalized by cells; more particularly the compositions comprise cell attachment peptides derived from or homologous to specific portions of the carboxy termini of fibrinogen chains, designated herein as Haptides, capable of enhancing the uptake of liposomes by cells. The present invention further relates to pharmaceutical and cosmetic compositions comprising haptotactic-peptide liposomal compositions and uses of same.

    Abstract translation: 本发明涉及包含肽的脂质体组合物，其特征在于它们引发细胞附着（触觉反应）反应并被细胞内化; 更具体地，组合物包含衍生自或同源于纤维蛋白原链的羧基末端（本文称为Haptides）的特异性部分的细胞附着肽，其能够增强细胞对脂质体的摄取。 本发明还涉及包含触头肽脂质体组合物的药物和化妆品组合物及其用途。

    Fibrin sealant glue-gun with insertable compressed gas cartridge and luer-type reservoir connectors
    9.
    发明授权
    Fibrin sealant glue-gun with insertable compressed gas cartridge and luer-type reservoir connectors 失效
    纤维素密封胶枪与可插入的压缩气瓶和鲁尔型储液器连接器

    公开(公告)号：US6059749A

    公开(公告)日：2000-05-09

    申请号：US816984

    申请日：1997-03-13

    Applicant: Gerard Marx

    Inventor： Gerard Marx

    IPC: A61B17/11 ,  A61B17/00 ,  A61B17/12 ,  B05B7/06 ,  B05B7/08 ,  B05C17/00 ,  B05D7/24 ,  A61M37/00 ,  A61B17/08 ,  A61M5/00 ,  A61M11/00

    CPC classification number: B05B7/0807 ,  A61B17/00491 ,  B05B7/065 ,  A61B2017/00495

    Abstract: An applicator for dispensing a substance comprising first and a second components of any mixture of fluids for either medical or other applications, in an exemplary application, a biological adhesive, such as a fibrin sealant, wherein the applicator comprises a housing having a first dispensing conduit for dispensing the first component and a second dispensing conduit for dispensing the second component. A pressure supply conduit is in communication with the dispensing conduits and both a first reservoir containing the first component, and a second reservoir containing the second component. A cartridge containing a biologically compatible compressed gas may be attached to the pressure supply conduit. The first and second reservoirs may each be provided with a luer fitting to facilitate attachment to a supply of the first component and the second component, respectively. A first pressure regulator, also in communication with the first reservoir, controls the pressure supplied through the pressure supply conduit to the first reservoir and a second pressure regulator, also in communication with the second reservoir, controls the pressure supplied through the pressure supply conduit to the second reservoir. The pressure regulators may be pressure regulating screws or valves, or they may comprise dispensing conduits having various cross sectional areas or reservoir conduits having various cross sectional areas. The applicator dispenses the first and second components, typically a thrombin solution and a fibrinogen solution, in controlled proportions by adjustment of the pressure regulators.

    Abstract translation: 一种用于分配物质的施加器，其包括用于医疗或其它应用的任何流体混合物的第一和第二组分，在示例性应用中，生物粘合剂，例如纤维蛋白密封剂，其中所述施用器包括具有第一分配导管 用于分配第一部件和用于分配第二部件的第二分配导管。 压力供应管道与分配管道连通，并且包含第一部件的第一储存器和包含第二部件的第二储存器。 包含生物相容的压缩气体的药筒可以附接到压力供应管道。 第一和第二储存器可以各自设置有鲁尔接头，以便于分别便于连接到第一部件和第二部件的供应。 还与第一储存器连通的第一压力调节器将通过压力供应管道供应的压力控制到第一储存器，并且还与第二储存器连通的第二压力调节器将通过压力供应管道供应的压力控制到 第二个水库。 压力调节器可以是压力调节螺钉或阀，或者它们可以包括具有各种横截面积的分配管道或具有各种横截面积的储存管道。 施用者通过调整压力调节器以受控的比例分配第一和第二组分，通常为凝血酶溶液和纤维蛋白原溶液。

    Biologic bioadhesive compositions containing fibrin glue and liposomes, methods of preparation and use
    10.
    发明授权
    Biologic bioadhesive compositions containing fibrin glue and liposomes, methods of preparation and use 失效

    公开(公告)号：US5607694A

    公开(公告)日：1997-03-04

    申请号：US459345

    申请日：1995-06-02

    Applicant: Gerard Marx

    Inventor： Gerard Marx

    IPC: A61K9/127 ,  A61K38/43 ,  A61K47/42 ,  A61L24/00 ,  A61L24/04 ,  A61L24/10 ,  A61P7/04 ,  A61P17/02

    CPC classification number: A61L24/106 ,  A61K47/42 ,  A61K9/127 ,  A61L24/0015 ,  A61L24/043 ,  A61L2300/102 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/428 ,  A61L2300/626 ,  Y10T428/2984

    Abstract: The present invention describes a biologically compatible bioadhesive sealant composition comprising fibrin glue and liposomes for use in mammals, including humans. Fibrin glue of the invention comprises fibrinogen and thrombin which are mixed together in various modes with liposomes and applied to a site of injury, to a wound, or to a surgical or nonsurgical incision or opening. In accordance with the invention, the liposomes are embedded within the fibrin glue after coagulation has occurred, and may release bioactive substances contained within their aqueous interiors to promote healing and protection during the recovery process. The bioadhesive composition of the invention promises to maintain hemostasis after surgeries and improves upon existing glues or gel formulations due to its complete biological compatibility, its formation in situ, and its provision of bioactive therapeutics via entrapped liposomes directly to the site. Long-lasting biophysical and biomechanical properties as well as therapeutic value are imparted to the fibrin glue components by the liposome component of the composition. The biocompatible fibrin glue and liposome composition is also amenable for fabrication into films, coatings, or membranes for in vitro and in vivo uses.

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