公开(公告)号：US20150112168A1

公开(公告)日：2015-04-23

申请号：US14061334

申请日：2013-10-23

Applicant: Google Inc.

Inventor： Andrew Conrad ,  Eric Peeters ,  Vikram Singh Bajaj ,  Jason Thompson ,  Mark Askew

IPC: A61B5/05

CPC classification number: A61B5/14546 ,  A61B5/0022 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/024 ,  A61B5/05 ,  A61B5/0515 ,  A61B5/055 ,  A61B5/1455 ,  A61B5/681 ,  A61B5/7228 ,  G01R33/24 ,  G01R33/44 ,  G06F19/00 ,  G16H40/63

Abstract: A method for modulating a response signal includes introducing functionalized magnetic particles configured to interact with target analytes into the body, applying a magnetic field sufficient to draw the functionalized magnetic particles towards a surface of the lumen of subsurface vasculature closest to an internally or externally applied mask having a spatial arrangement, and detecting a response signal, which includes a background signal and an analyte response signal, transmitted from the subsurface vasculature. The analyte response signal related to interaction of the functionalized magnetic particles with the target analytes and is modulated with respect to the background signal due, at least in part, to the spatial arrangement of the mask. The target analytes may be non-invasively detected by differentiating the analyte response signal from the background signal due, at least in part, to the modulation of the analyte response signal.

Abstract translation: 用于调节响应信号的方法包括引入配置成与目标分析物相互作用的功能化磁性颗粒进入体内，施加足以将官能化的磁性颗粒吸引到最靠近内部或外部施加的掩模的地下脉管系统的内腔表面的磁场 具有空间布置，并且检测包括从地下脉管系统发送的背景信号和分析物响应信号的响应信号。 分析物响应信号与功能化磁性颗粒与目标分析物的相互作用相关，并且相对于背景信号被调制，至少部分地由于掩模的空间排列。 目标分析物可以通过区分来自背景信号的分析物响应信号而被非侵入性地检测，至少部分地由于分析物响应信号的调制。

公开(公告)号：US20150110721A1

公开(公告)日：2015-04-23

申请号：US14061251

申请日：2013-10-23

Applicant: Google Inc.

Inventor： Andrew Conrad ,  Eric Peeters ,  Vikram Singh Bajaj ,  Jason Thompson ,  Mark Askew

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/05 ,  A61K49/18

CPC classification number: A61B5/14546 ,  A61B5/0071 ,  A61B5/05 ,  A61B5/681 ,  A61B5/7203 ,  A61B5/742

Abstract: A method for modulating a response signal includes introducing functionalized particles into a lumen of subsurface vasculature, wherein the functionalized particles are configured to interact with one or more target analytes present in blood circulating in the subsurface vasculature; and non-invasively detecting the one or more target analytes. A response signal, which may include a background signal and an analyte response signal related to interaction of the functionalized particles with the one or more target analytes, is transmitted from the subsurface vasculature. A modulation configured to alter the response signal such that the analyte response signal is affected differently than the background signal may be applied to a portion of subsurface vasculature. Analyte detection may be achieved by differentiating the analyte response signal from the background signal.

Abstract translation: 用于调节响应信号的方法包括将功能化颗粒引入地下脉管系统的内腔，其中功能化颗粒被配置为与存在于在地下脉管系统中循环的血液中的一种或多种目标分析物相互作用; 并非侵入性地检测一种或多种目标分析物。 响应信号可以包括背景信号和与功能化颗粒与一种或多种目标分析物的相互作用相关的分析物响应信号，从地下脉管系统传输。 被配置为改变响应信号以使得分析物响应信号受影响不同于背景信号的调制可以应用于一部分地下脉管系统。 可以通过将分析物响应信号与背景信号进行微分来实现分析物检测。

公开(公告)号：US20150112167A1

公开(公告)日：2015-04-23

申请号：US14061325

申请日：2013-10-23

Applicant: Google Inc.

Inventor： Andrew Conrad ,  Eric Peeters ,  Vikram Singh Bajaj ,  Jason Thompson ,  Mark Askew

IPC: A61B5/05 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61B5/14546 ,  A61B5/0022 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/024 ,  A61B5/05 ,  A61B5/0515 ,  A61B5/055 ,  A61B5/1455 ,  A61B5/681 ,  A61B5/7228 ,  G01R33/24 ,  G01R33/44 ,  G06F19/00 ,  G16H40/63

Abstract: A system for modulating a response signal includes functionalized particles configured to interact with target analytes, a detector configured to detect an analyte response signal transmitted from the body, a modulation source configured to modulate the analyte response signal, and a processor configured to non-invasively detect the one or more target analytes by differentiating the analyte response signal from a background signal, at least in part, based on the modulation. The analyte response signal is related to the interaction of the target analytes with the functionalized particles. In some examples, the system may also include magnetic particles and a magnetic field source sufficient to distribute the magnetic particles into a spatial arrangement in the body. The analyte response signal may be differentiated from the background signal, at least in part, based on modulation of the signals due, at least in part, to the spatial arrangement of the magnetic particles.

Abstract translation: 用于调制响应信号的系统包括配置成与目标分析物相互作用的功能化颗粒，被配置为检测从身体传输的分析物响应信号的检测器，配置成调制分析物响应信号的调制源和被配置为非侵入性的处理器 至少部分地基于调制，通过将分析物响应信号与背景信号区分开来来检测一种或多种目标分析物。 分析物响应信号与目标分析物与官能化颗粒的相互作用有关。 在一些示例中，该系统还可以包括磁性颗粒和足以将磁性颗粒分布到体内的空间布置的磁场源。 至少部分地基于至少部分地由于至少部分地对磁性颗粒的空间布置的信号的调制而将分析物响应信号与背景信号区分开。