公开(公告)号：WO8704926A3

公开(公告)日：1988-05-19

申请号：PCT/GB8700111

申请日：1987-02-16

Applicant: HABIB NAGY ADLY ,  WOOD CHRISTOPHER BARRY ,  APOSTOLOV KOSTA ,  BARKER WILLIAM ROLAND

Inventor： HABIB NAGY ADLY ,  WOOD CHRISTOPHER BARRY ,  APOSTOLOV KOSTA ,  BARKER WILLIAM ROLAND

IPC: C07C57/02 ,  A61K31/20 ,  A61K31/23 ,  A61P31/12 ,  A61P35/00 ,  C07C51/00 ,  C07C53/126 ,  C07C53/19 ,  C07C57/12 ,  C07C67/00

CPC classification number: A61K31/23 ,  A61K31/20

Abstract: Use of certain fatty acids in effecting modifications to the lipid structure of cell membranes. The invention also relates to the formulation of pharmaceutical compositions and medicaments and to such products per se; to the treatment of a variety of clinical and veterinary disorders associated with elevation of the saturation index of cell membranes, including nervous disorders including multiple sclerosis and schizophrenia; and to the use of the active materials of the invention in the treatment thereof. The active principles in the present invention are mono-unsaturated fatty acids having from 12 to 28 carbon atoms in the alkyl chain, e.g. oleic acid, or pharmaceutically acceptable derivatives thereof.

公开(公告)号：DK537087D0

公开(公告)日：1987-10-14

申请号：DK537087

申请日：1987-10-14

Applicant: HABIB NAGY ADLY

Inventor： HABIB NAGY ADLY ,  WOOD CHRISTOPHER BARRY ,  APOSTOLOV KOSTA ,  BARKER WILLIAM ROLAND

IPC: C07C57/02 ,  A61K31/20 ,  A61K31/23 ,  A61P31/12 ,  A61P35/00 ,  C07C51/00 ,  C07C53/126 ,  C07C53/19 ,  C07C57/12 ,  C07C67/00

Abstract: The invention is concerned with the use of certain fatty acids and inhibitors of an enzyme in effecting modifications to the lipid structure of cell membranes. The invention also relates to the formulation of pharmaceutical compositions and medicaments and to such products per se; to the treatment of a variety of clinical and veterinary disorders associated with a lowering of the saturation index of cell membranes, including malignancies, viral disorders and AIDS; and to the use of the active materials of the invention in the relief of pain. The active principals in the present invention are saturated fatty acids having from 12 to 28 carbon atoms in the alkyl chain, e.g. stearic acid, or pharmaceutically acceptable derivatives thereof; and inhibitors of the enzyme DELTA -9 desaturase, e.g. sterculic acid and malvalic acid or pharmacologically active derivatives or analogues thereof.

公开(公告)号：DK72187D0

公开(公告)日：1987-02-13

申请号：DK72187

申请日：1987-02-13

Applicant: HABIB NAGY ADLY

Inventor： HABIB NAGY ADLY ,  WOOD CHRISTOPHER BARRY ,  APOSTOLOV KOSTA ,  BARKER WILLIAM ROLAND

IPC: A61K31/20 ,  A61K31/23 ,  C07C53/126 ,  A61K35/78 ,  A61K45/00 ,  C07C53/19 ,  C12N9/00 ,  C12P21/00

公开(公告)号：DK537087A

公开(公告)日：1987-12-07

申请号：DK537087

申请日：1987-10-14

Applicant: HABIB NAGY ADLY

Inventor： HABIB NAGY ADLY ,  WOOD CHRISTOPHER BARRY ,  APOSTOLOV KOSTA ,  BARKER WILLIAM ROLAND

IPC: C07C57/02 ,  A61K31/20 ,  A61K31/23 ,  A61P31/12 ,  A61P35/00 ,  C07C51/00 ,  C07C53/126 ,  C07C53/19 ,  C07C57/12 ,  C07C67/00

Abstract: The invention is concerned with the use of certain fatty acids and inhibitors of an enzyme in effecting modifications to the lipid structure of cell membranes. The invention also relates to the formulation of pharmaceutical compositions and medicaments and to such products per se; to the treatment of a variety of clinical and veterinary disorders associated with a lowering of the saturation index of cell membranes, including malignancies, viral disorders and AIDS; and to the use of the active materials of the invention in the relief of pain. The active principals in the present invention are saturated fatty acids having from 12 to 28 carbon atoms in the alkyl chain, e.g. stearic acid, or pharmaceutically acceptable derivatives thereof; and inhibitors of the enzyme DELTA -9 desaturase, e.g. sterculic acid and malvalic acid or pharmacologically active derivatives or analogues thereof.

公开(公告)号：DK72187A

公开(公告)日：1987-10-23

申请号：DK72187

申请日：1987-02-13

Applicant: HABIB NAGY ADLY

Inventor： HABIB NAGY ADLY ,  WOOD CHRISTOPHER BARRY ,  APOSTOLOV KOSTA ,  BARKER WILLIAM ROLAND

IPC: A61K31/20 ,  A61K31/23 ,  C07C53/126 ,  A61K35/78 ,  A61K45/00 ,  C07C53/19 ,  C12N9/00 ,  C12P21/00