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    Fluorescence analyzer and analysis method
    1.
    发明专利
    Fluorescence analyzer and analysis method 有权
    荧光分析仪和分析方法

    公开(公告)号：JP2009192490A

    公开(公告)日：2009-08-27

    申请号：JP2008036215

    申请日：2008-02-18

    Applicant: Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

    Inventor： TAKAMOTO HISANOBU ,  HASEGAWA HIROSHI ,  SUGIE MASAMI

    IPC: G01N21/64

    Abstract: PROBLEM TO BE SOLVED: To provide a fluorescence analyzer and analysis method that facilitate fluorescence analysis of a measuring sample. SOLUTION: This fluorescence analyzer 1A comprises an excitation light irradiation system for irradiating a sample S with an exciting light; a fluorescence detecting system for detecting the fluorescence from a fluorescence probe in a measuring area; a photon-counting section 35 for counting the number of photons, based on a detected signal, an analysis condition setting section 51 for setting the analysis condition to the number-of photons measuring data, and a measurement result analysis section 52 for performing the fluorescence analysis. The setting section 51 sets bin width for binning the measuring data, and the reference number of photons to one molecule of the fluorescence probe 1. The analysis section 52 performs binning of the measuring data, and analyses the number of fluorescence probes in the measuring area with reference to the reference number of photons. The setting section 51 sets the bin width using the variation with the bin width of the measure S/N ratio of the number of photons and the reference S/N ratio by shot-noise characteristics. COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：提供促进测量样品的荧光分析的荧光分析仪和分析方法。 解决方案：该荧光分析仪1A包括用于用激发光照射样品S的激发光照射系统; 用于在测量区域中检测来自荧光探针的荧光的荧光检测系统; 基于检测信号对光子数进行计数的光子计数部35，将分析条件设定为光子数测定数据的分析条件设定部51，以及进行荧光的测定结果分析部52 分析。 设置部分51将测量数据的bin宽度和将光子的参考数目设置为一个分子的荧光探针1.分析部分52执行测量数据的分档，并且分析测量区域中的荧光探针的数量 参考光子的参考数。 设置部分51使用具有光子数量的测量S / N比的bin宽度和通过镜头噪声特性的参考S / N比的变化来设置纸槽宽度。 版权所有（C）2009，JPO＆INPIT

    ENDOSCOPIC DEVICE
    2.
    发明专利
    ENDOSCOPIC DEVICE 失效

    公开(公告)号：JPH06125911A

    公开(公告)日：1994-05-10

    申请号：JP27713492

    申请日：1992-10-15

    Applicant: HAMAMATSU PHOTONICS KK

    Inventor： HIRANO KENICHI ,  SUGIE MASAMI ,  YONEZAWA MICHIHARU

    IPC: A61B10/00 ,  A61B1/00 ,  G01N21/64 ,  G02B23/24

    Abstract: PURPOSE:To provide an endoscopic device in which a fluorescent image can be picked up and displayed, together with an appearance image, only if fluorescence with more than predetermined luminous strength is detected. CONSTITUTION:When illuminating light involving excitation light is emitted from a light source 56, it is separated by a rotating filter 58 into normal illumination light and excitation light, which are then applied alternately to a subject 51 for inspection. The appearance image and fluorescent image of the subject for inspection are guided by an image guide fiber 53 and caused to impinge on respective first and second CCD cameras 62, 63. The fluorescence of the subject for inspection is detected by a photodetector 69 and only when its luminous strength is at or greater than a set value an image intensifier 65 is operated to double the luminous strength of the fluorescent image and then the image is picked up by the second CCD camera 63. At an image processing circuit 66 the fluorescent image is combined with the appearance image from the first camera 62 and the composite image is displayed on a monitor 67.

    Compost decay degree determination method and its device
    4.
    发明专利
    Compost decay degree determination method and its device 有权
    组合衰减度测定方法及其设备

    公开(公告)号：JP2005274222A

    公开(公告)日：2005-10-06

    申请号：JP2004085139

    申请日：2004-03-23

    Applicant: Hamamatsu Photonics Kk ,  Shizuoka Prefecture ,  浜松ホトニクス株式会社 ,  静岡県

    Inventor： YAMADA MAYUKO ,  TSUCHIYA KOJI ,  SUGIE MASAMI ,  KATAYAMA SHINYA

    IPC: G01N21/63 ,  G01N1/10 ,  G01N1/28 ,  G01N21/76

    Abstract: PROBLEM TO BE SOLVED: To provide a compost decay degree determination method and its device for simply, rapidly, and quantitatively determining the decay degree of compost.
    SOLUTION: It is found out that a compost extract produced from compost emits faint light (biophotons) and that a correlation exists between the light amount of the faint light and the decay degree of the compost. According to this method, first, a compost extract is produced from compost. Subsequently, the number of photons emitted from the compost extract is measured by using a photomultiplier, etc. Then, the decay degree of the compost is determined based on a previously found correlation between the number of photons emitted from the compost extract and the decay degree of the compost.
    COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题：提供堆肥衰减度确定方法及其装置，用于简单，快速和定量地确定堆肥的腐烂程度。 解决方案：发现由堆肥产生的堆肥提取物发出微弱的光（生物光子），并且微弱光的光量与堆肥的衰变程度之间存在相关性。 根据该方法，首先从堆肥中生产堆肥提取物。 随后，通过使用光电倍增管等测量从堆肥提取物发射的光子的数量。然后，基于先前发现的从堆肥提取物发射的光子数与衰减程度之间的相关性来确定堆肥的衰变程度 的堆肥。 版权所有（C）2006，JPO＆NCIPI

    FAINT LIGHT MEASURING APPARATUS
    5.
    发明专利
    FAINT LIGHT MEASURING APPARATUS 失效

    公开(公告)号：JPH08285777A

    公开(公告)日：1996-11-01

    申请号：JP8686695

    申请日：1995-04-12

    Applicant: HAMAMATSU PHOTONICS KK

    Inventor： MOTOSAWA KATSU ,  SATOU HIROE ,  SUGIE MASAMI

    IPC: G01N21/76 ,  C12M1/34 ,  G01J1/02 ,  G01N21/01 ,  G01N21/15

    Abstract: PURPOSE: To measure the quantity of faint light emitted from a biological sample with high sensitivity by setting the upper surface temperature of a sample case higher than the lower surface temperature and measuring quantity of light emitted from the sample by means of a light quantity sensor. CONSTITUTION: A plurality of laboratory dishes 30 containing sterilized water and a biological sample are set in the recesses of a rotary stage 20 and then the door of a sample chamber 10 is closed to bring about dark room state. Based on a command delivered from a controller/processor 70, a temperature regulator 41 heats up the upper surface of the laboratory dish 30 by means of a silicon rubber heater 40 depending on the temperature measured by means of a temperature sensor 60 thus setting the upper surface temperature higher by 0.1-1 deg.C than the lower surface temperature. Subsequently, the controller 70 controls a pulse motor 21 to turn the stage 20 thus transferring the laboratory dishes 30 sequentially under the light receiving surface of a photomultiplier 50. When the the laboratory dishes 30 containing the sample is arranged under the photomultiplier 50, the controller 70 commands an electromagnetic shutter 50 to open for a predetermined time and the quantity of faint light emitted from the sample is measured by means of the photomultiplier 50 and a photocounter 53 thus measuring a faint light accurately with high sensitivity.

    Electron tube socket and method of manufacturing the same
    7.
    发明专利
    Electron tube socket and method of manufacturing the same 有权
    电子管插座及其制造方法

    公开(公告)号：JP2009181878A

    公开(公告)日：2009-08-13

    申请号：JP2008021158

    申请日：2008-01-31

    Applicant: Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

    Inventor： SUGIE MASAMI ,  WATASE FUMIO

    IPC: H01R33/76 ,  H01R13/58 ,  H01R43/00

    Abstract: PROBLEM TO BE SOLVED: To provide an electron tube socket for easily and surely fixing a cable to a casing, and to provide a method of manufacturing the same. SOLUTION: In the electron tube socket 1, the cable 2 is inserted through a through-hole 11 of the casing 8 and a through-hole 16 of a cable holding part 13; and an opening portion 11a of the through-hole 11 and an opening portion 16a of the through-hole 16 are partially overlapped with each other to be narrower than the width of the cable 2 in a predetermined direction A. The cable 2 is therefore held between a bottom part 9 of the casing 8 and the cable holding part 13. Thus, the electron tube socket 1 allows easy and sure fixing of the cable 2 to the casing 8. COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种用于容易且可靠地将电缆固定到壳体上的电子管插座，并提供其制造方法。 解决方案：在电子管插座1中，电缆2穿过壳体8的通孔11和电缆保持部13的通孔16插入; 并且通孔11的开口部分11a和通孔16的开口部分16a彼此部分地重叠以比预定方向A上的电缆2的宽度窄。电缆2因此被保持 在壳体8的底部9和电缆保持部13之间。因此，电子管插座1允许电缆2容易且可靠地固定到壳体8.版权所有：（C）2009，JPO＆INPIT

    Fluorescence analyzer and analysis method
    9.
    发明专利
    Fluorescence analyzer and analysis method 有权
    荧光分析仪和分析方法

    公开(公告)号：JP2009281831A

    公开(公告)日：2009-12-03

    申请号：JP2008133562

    申请日：2008-05-21

    Applicant: Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

    Inventor： TAKAMOTO HISANOBU ,  HASEGAWA HIROSHI ,  SUGIE MASAMI ,  KATO SUSUMU

    IPC: G01N21/64

    Abstract: PROBLEM TO BE SOLVED: To provide a fluorescence analyzer and an analysis method capable of executing properly fluorescence analysis of a sample. SOLUTION: This analyzer 1A is constituted of: an excitation light source 22 for irradiating excitation light to a measuring domain of the sample S; a beam splitter 30 for branching fluorescence from a fluorescence probe in the measuring domain; first and second photodetectors 31, 32 for detecting branched fluorescence components respectively; a photon counting part 35 for counting in time series, the number of photons detected respectively by the photodetectors 31, 32, and acquiring first and second measurement data F A (t), F B (t); and a measuring control part 50 including an analysis data generation part 51 and a measurement result analysis part 52. The generation part 51 generates photon number analysis data n AB (t) wherein, in the case of F A ×F B =0, n AB =0, and in the case of F A ×F B >0, n AB =f(F A , F B ) in terms of a prescribed function f, and the analysis part 52 performs fluorescence analysis relative to the analysis data. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题：提供能够对样品进行适当的荧光分析的荧光分析仪和分析方法。 解决方案：该分析器1A由激发光源22构成，用于将激发光照射到样品S的测量域; 用于在测量域中分布来自荧光探针的荧光的分束器30; 用于分别检测支化荧光成分的第一和第二光电检测器31,32; 用于时间序列计数的光子计数部分35，由光电探测器31,32分别检测的光子数，并获取第一和第二测量数据F（SB） / SB>（t）; 以及包括分析数据生成部51和测量结果分析部52的测量控制部50.生成部51生成光子数分析数据AB（SB），其中，在F < SB> A ×F B = 0，n AB = 0，在F A ×F > 0，n AB = f（F A ，F B ）， 分析部52对分析数据进行荧光分析。 版权所有（C）2010，JPO＆INPIT

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