公开(公告)号：WO2008002981A3

公开(公告)日：2008-10-16

申请号：PCT/US2007072248

申请日：2007-06-27

Applicant: HARVARD COLLEGE ,  PEER FISCHER ,  GHOSH AMBARISH

Inventor： PEER FISCHER ,  GHOSH AMBARISH

IPC: G01J4/02

CPC classification number: G01J4/02 ,  G01N21/23

Abstract: A system and method for detection and measurement of circular birefringences in materials, such as optically active (chiral) liquids and materials that exhibit the Faraday effect. The method and apparatus permit the detection of optical activities via the difference in the directions of propagation the left- and the right- circularly polarized light (components). A beam of light is directed at an interface formed by the optically active medium and another medium such that a difference in the angles of refraction and/or reflection and/or diffraction between the left- and the right-circularly polarized components of the light beam can be detected. The difference in the propagation directions between the two circularly polarized light components is measured on a position sensitive detector and/or is detected as an intensity difference. The circular birefringence in isotropic liquids is a measure of their optical purity (enantiomeric excess) and hence the invention presents a method and apparatus to measure chirality. The invention is thus related to optical rotation (polarimetric) measurements, but has the advantage that it does not depend on path-length traversed through the sample.

Abstract translation: 用于检测和测量材料中的圆形双折射的系统和方法，例如光学活性（手性）液体和显示法拉第效应的材料。 该方法和装置允许通过左右圆偏振光（分量）的传播方向的差异来检测光学活动。 光束指向由光学活性介质和另一介质形成的界面，使得光束的左旋圆偏振分量和右旋圆偏振分量之间的折射角和/或反射角和/或衍射的差 可以被检测到。 在位置敏感检测器上测量两个圆偏振光分量之间的传播方向的差异和/或检测为强度差。 各向同性液体中的圆形双折射是其光学纯度（对映体过量）的量度，因此本发明提供了测量手性的方法和装置。 因此，本发明涉及旋光（极化）测量，但具有不依赖于穿过样品的路径长度的优点。

公开(公告)号：EP2041537A4

公开(公告)日：2010-01-27

申请号：EP07799089

申请日：2007-06-27

Applicant: HARVARD COLLEGE

Inventor： PEER FISCHER ,  GHOSH AMBARISH

IPC: G01N21/23 ,  G01J4/02

CPC classification number: G01J4/02 ,  G01N21/23