公开(公告)号：US11203647B2

公开(公告)日：2021-12-21

申请号：US16740576

申请日：2020-01-13

Applicant: HEFEI UNIVERSITY OF TECHNOLOGY

Inventor： Bao Zhang ,  Baocai Xu ,  Xiaomin Li ,  Peijun Li ,  Yi Pan ,  Ran Meng ,  Xiaolong Li ,  Wenjie Liu

IPC: C08B30/18 ,  A61K8/02 ,  A61K9/51 ,  A61K8/73 ,  A61K8/35

Abstract: The present application discloses dual-function starch-based composite nanoparticles as well as a preparation method and application thereof. The preparation method comprises: hydrolyzing starch to form linear dextrin, grading the linear dextrin by using an alcohol-alcohol gradient precipitation method to obtain linear dextrin having homogeneous molecular weight distribution; oxidizing the linear dextrin by adopting an oxidation system to obtain oxidized dextrin; carrying out complex reaction on the oxidized dextrin and curcumin to form an oxidized dextrin-curcumin complex; and forming an oxidized dextrin-curcumin/chitosan hydrochloride composite nanoparticles from the oxidized dextrin-curcumin complex and chitosan hydrochloride. The aqueous phase solution of the dual-function starch-based composite nanoparticles containing gel polysaccharide is uniformly mixed with primary emulsion, calcium ion induction is carried out on the obtained double emulsion to obtain double-emulsion gel.

公开(公告)号：US12083231B2

公开(公告)日：2024-09-10

申请号：US17715970

申请日：2022-04-08

Applicant: Hefei University of Technology

Inventor： Bao Zhang ,  Wenjie Liu ,  Han Tao ,  Xiaolong Li ,  Pin Chen ,  Rumeng Wang

IPC: A61K9/51 ,  A23P10/30 ,  B05D1/00 ,  C07K14/465 ,  C07K19/00 ,  C08B30/18 ,  C12P19/04 ,  C12P19/16 ,  C12P21/06

CPC classification number: A61K9/5192 ,  A23P10/30 ,  A61K9/5161 ,  B05D1/007 ,  C07K14/465 ,  C07K19/00 ,  C08B30/18 ,  C12P19/04 ,  C12P19/16 ,  C12P21/06

Abstract: The preparation method of a starch-based double-loaded functional nanoparticle includes: performing restrictive hydrolysis treatment on egg high-density lipoprotein using proteases to obtain the polypeptide; performing self-assembling on a mixed system containing the polypeptide and quercetin under the alkaline condition to form a micelle nanoparticle; performing covalent grafting reaction on a mixed system containing the micelle nanoparticle and anthocyanin under the alkaline condition to form a graft; and electrostatically compounding carboxymethyl dextrin with the graft to obtain the starch-based double-loaded functional nanoparticle. In the preparation method, raw materials derived from natural sources are used, and the self-assembled colloid nanoparticle with good properties can be obtained by adjusting the pH without any organic reagents. The obtained product has a nanoparticle size, has high antioxidant activity and stability against environmental stress, and can be widely applied to the fields of delivery of nutrients, stabilization of biologically active substances and the like.