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公开(公告)号：WO2005077446A1
公开(公告)日：2005-08-25
申请号：PCT/US2005/004064
申请日：2005-02-09
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , CHILDERS, Winthrop, D. , TYVOLL, David , SEXTON, Douglas, A.
Inventor： CHILDERS, Winthrop, D. , TYVOLL, David , SEXTON, Douglas, A.
IPC: A61M15/00
CPC classification number: A61M15/0065 , A61M11/001 , A61M11/005 , A61M11/06 , A61M15/0066 , A61M15/008 , A61M15/025 , A61M2205/3355
Abstract: A medicament dispenser (10) that includes a medicament supply (24), an ejector (26), and a controller (28) configured to actuate the ejector, where the controller is configured to use an operational parameter to produce a plurality of medicament drops (46) having a target drop characteristic, and the operational parameter includes a correction factor that is based on a performance characteristic of the ejector.
Abstract translation: 一种药物分配器（10），其包括药物供给器（24），喷射器（26）和配置成致动喷射器的控制器（28），其中所述控制器被配置为使用操作参数来产生多个药液滴 （46）具有目标液滴特性，并且所述操作参数包括基于所述喷射器的性能特性的校正因子。
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公开(公告)号：WO2005102527A1
公开(公告)日：2005-11-03
申请号：PCT/US2005/006992
申请日：2005-03-04
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , CHILDERS, Winthrop, D. , TYVOLL, David , NORTON, Kirk
Inventor： CHILDERS, Winthrop, D. , TYVOLL, David , NORTON, Kirk
IPC: B01L3/00
CPC classification number: B03C5/028 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2400/0424 , B01L2400/0436 , B01L2400/0439 , B01L2400/0487 , B01L2400/0496 , C12M33/00
Abstract: A method of transporting cells comprising transporting a plurality of cells (80) through a transport path (70/206) of a biodevice (10) and maintaining substantially free individual movement of each cell during the transporting of the cells through the transport path.
Abstract translation: 一种传送细胞的方法，包括通过生物器官（10）的传送路径（70/206）传送多个细胞（80），并且在细胞通过传送路径传输期间保持每个细胞的基本上免费的单独移动。
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公开(公告)号：WO2005072601A1
公开(公告)日：2005-08-11
申请号：PCT/US2004/043044
申请日：2004-12-20
Inventor： CHILDERS, Wintrhop D. , TYVOLL, David
IPC: A61B5/00
CPC classification number: A61B5/14532 , A61B5/1486 , A61B2562/085 , G01N33/48771
Abstract: A disposable blood test device comprises a substrate configured for carrying a chemical reagent and circuitry formed on the substrate. The circuitry comprises a sensor portion associated with the chemical reagent to enable measurement of at least one of a presence and a concentration of a blood analyte, and an information storage portion configured to store information indicative of a property of the chemical reagent.
Abstract translation: 一次性血液检查装置包括被配置为承载化学试剂和形成在基底上的电路的基底。 电路包括与化学试剂相关联的传感器部分，以能够测量血液分析物的存在和浓度中的至少一种，以及配置为存储指示化学试剂的性质的信息的信息存储部分。
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公开(公告)号：WO2005072600A1
公开(公告)日：2005-08-11
申请号：PCT/US2004/043032
申请日：2004-12-20
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , TYVOLL, David , CHILDERS, Winthrop, D. , NORTON, Kirkpatrick, W. , JOHNSON, Bryan, J.
Inventor： TYVOLL, David , CHILDERS, Winthrop, D. , NORTON, Kirkpatrick, W. , JOHNSON, Bryan, J.
IPC: A61B5/00
CPC classification number: A61B5/1486 , A61B5/14532 , A61B2562/0295 , G01N27/3271 , G01N33/491 , Y10T436/144444 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
Abstract: A method of analyzing blood comprises delivering a blood sample to a test device, applying a spatially varying electric field to the blood sample to provide a depleted cell concentration in a portion of the blood sample, and sensing a property of the portion of the blood sample.
Abstract translation: 分析血液的方法包括将血液样品递送到测试装置，向血液样品施加空间变化的电场，以在血液样品的一部分中提供耗尽的细胞浓度，并感测血液样品的一部分的性质 。
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公开(公告)号：WO2004039500A1
公开(公告)日：2004-05-13
申请号：PCT/US2003/034863
申请日：2003-10-30
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： CHILDERS, Winthrop D. , TYVOLL, David
IPC: B01L3/00
CPC classification number: B01L3/50273 , B01L3/502707 , B01L3/502715 , B01L3/502753 , B01L2200/027 , B01L2200/10 , B01L2200/143 , B01L2300/0645 , B01L2300/0681 , B01L2300/0861 , B01L2300/1827 , B01L2400/0415 , B01L2400/0487 , B01L2400/0633 , G01N1/28 , G01N2035/00247 , G01N2035/00326 , G06F19/00 , Y02A90/26
Abstract: A system (10) is provided, including apparatus and methods, for microfluidic processing and/or analysis of a nucleic acid(s) (127) in a sample having the nucleic acid(s) and waste material. The system (10) includes a microfluidic device (14) having a fluid-handling portion (42) and an assay portion (44). The fluid-handling portion (42) may be configured to move fluid mechanically and defines at least one fluid compartment (54). The fluid-handling portion (42) is configured to receive the sample and to pre-process the sample in the fluid compartment (54) to at least partially separate the nucleic acid (127) from the waste material. The assay portion (44) interfaces with the fluid-handling portion (42) and defines at least one fluid chamber. The fluid chamber is connected fluidically to the fluid compartment (54). The assay portion (44) includes electronics (58) configured to process the nucleic acid (127) in the fluid chamber.
Abstract translation: 提供了一种系统（10），包括用于在具有核酸和废物的样品中的微流体处理和/或分析核酸（127）的装置和方法。 系统（10）包括具有流体处理部分（42）和测定部分（44）的微流体装置（14）。 流体处理部分（42）可以被配置为机械地移动流体并限定至少一个流体室（54）。 流体处理部分（42）构造成接收样品并且将流体室（54）中的样品预处理，以将核酸（127）与废物材料至少部分分离。 测定部分（44）与流体处理部分（42）接合并限定至少一个流体室。 流体室流体地连接到流体室（54）。 测定部分（44）包括被配置为处理流体室中的核酸（127）的电子器件（58）。
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Patent Agency Ranking
公开(公告)号：WO2005099796A1
公开(公告)日：2005-10-27
申请号：PCT/US2005/012108
申请日：2005-04-08
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , CHILDERS, Wintrhop, D. , SEXTON, Douglas, A. , TYVOLL, David
Inventor： CHILDERS, Wintrhop, D. , SEXTON, Douglas, A. , TYVOLL, David
IPC: A61M15/00
CPC classification number: A61M15/025 , A61M11/001 , A61M15/0003 , A61M15/0065 , A61M2205/70
Abstract: A medication dispenser (6) includes a thermal drop generator ejector head (20). Medication is maintained in a pressurized container (14) connected to a valve (17) under the control of control electronics (24) and to a compliant chamber (16). Fluid flows from the container (14) to the chamber (16) and to the ejector head (20). In a first mode (8) the dispenser is operable to dispense aerosolized medication. In a second mode (10) the ejector head is purged with fluid from the container to maintain the ejector head (20).
Abstract translation: 药剂分配器（6）包括热滴发生器喷射头（20）。 在控制电子装置（24）的控制下，将药剂保持在与阀（17）连接的加压容器（14）中并且与顺应室（16）相连。 流体从容器（14）流到腔室（16）和喷射头（20）。 在第一模式（8）中，分配器可操作以分配雾化药物。 在第二模式（10）中，喷射头被从容器中吹出以保持喷射头（20）。
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公开(公告)号：WO2004069412A1
公开(公告)日：2004-08-19
申请号：PCT/US2004/002435
申请日：2004-01-28
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , PEASE, Grant , GHOZEIL, Adam, L. , DUNFIELD, John, Stephen , CHILDERS, Winthrop, D. , TYVOLL, David , SEXTON, Douglas, A. , CRIVELLI, Paul
Inventor： PEASE, Grant , GHOZEIL, Adam, L. , DUNFIELD, John, Stephen , CHILDERS, Winthrop, D. , TYVOLL, David , SEXTON, Douglas, A. , CRIVELLI, Paul
IPC: B01L3/00
CPC classification number: B01L7/525 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2200/147 , B01L2300/024 , B01L2300/0816 , B01L2300/0874 , B01L2300/1827 , B01L2300/1883 , B01L2400/0415 , Y10T436/11 , Y10T436/2575
Abstract: A microfluidic device (90) for analysis of a sample. The microfluidic device includes a substrate portion (94) that at least partially defines a chamber (102) for receiving the sample. The substrate portion (94) includes a substrate (98) having a surface (96). The substrate portion (94) also includes a plurality of thin-film layers (110) formed on the substrate (98) adjacent the surface (96). The thin-film layers (110) form a plurality of electronic devices. Each of at least two of the electronic devices is formed by a different set of the thin-film layers (110). The at least two electronic devices may include 1) a temperature control device for controlling the temperature of fluid in the chamber (102), and 2) an other electronic device configured to sense or modify a property of fluid in the chamber (102).
Abstract translation: 一种用于分析样品的微流体装置（90）。 微流体装置包括至少部分地限定用于接收样品的室（102）的基底部分（94）。 衬底部分（94）包括具有表面（96）的衬底（98）。 衬底部分（94）还包括在邻近表面（96）的基底（98）上形成的多个薄膜层（110）。 薄膜层（110）形成多个电子装置。 至少两个电子器件中的每一个由不同的薄膜层组合（110）形成。 所述至少两个电子装置可以包括：1）用于控制所述腔室（102）中的流体温度的温度控制装置，以及2）构造成感测或改变所述腔室（102）中的流体性质的另一电子装置。
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公开(公告)号：WO2004042367A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/034750
申请日：2003-10-30
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： CHILDERS, Winthrop D. , CRIVELLLI, Paul , TYVOLL, David , FEINN, James A. , SEXTON, Douglas A.
IPC: G01N1/28
CPC classification number: B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L2200/10 , B01L2200/12 , B01L2200/14 , B01L2300/02 , B01L2300/0645 , B01L2300/0887 , B01L2300/1827 , B01L2400/0415 , G01N1/28 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575 , Y10T436/25875
Abstract: Systems (10), including apparatus and methods, for microfluidic processing and/or analysis of samples. The systems include a microfluidic device (14) having a substrate (160) and a thin-film layer (190) formed on the substrate (160). The thin-film layer (190) may be included in electronics (58) formed on the substrate (160). The electronics (58) may provide electronic devices configured to sense or modify a property of the sample. The thin-film layer (190) defines an opening (188) for routing movement of fluid and/or sample within the device.
Abstract translation: 系统（10），包括用于微流体处理和/或样品分析的装置和方法。 该系统包括具有衬底（160）和形成在衬底（160）上的薄膜层（190）的微流体装置（14）。 薄膜层（190）可以被包括在形成在基板（160）上的电子器件（58）中。 电子器件（58）可以提供被配置为感测或修改样本的性质的电子设备。 薄膜层（190）限定了开口（188），用于引导装置内的流体和/或样品的运动。
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9.发明公开MICROFLUIDIC SYSTEM UTILIZING THIN-FILM LAYERS TO ROUTE FLUID 审中-公开与薄膜层用于输送流体MICROFLUIDISCHE DEVICE
公开(公告)号：EP1558908A2
公开(公告)日：2005-08-03
申请号：EP03781646.9
申请日：2003-10-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： CHILDERS, Winthrop D. , CRIVELLLI, Paul , TYVOLL, David , FEINN, James A. , SEXTON, Douglas A.
IPC: G01N1/28
CPC classification number: B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L2200/10 , B01L2200/12 , B01L2200/14 , B01L2300/02 , B01L2300/0645 , B01L2300/0887 , B01L2300/1827 , B01L2400/0415 , G01N1/28 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575 , Y10T436/25875
Abstract: Systems (10), including apparatus and methods, for microfluidic processing and/or analysis of samples. The systems include a microfluidic device (14) having a substrate (160) and a thin-film layer (190) formed on the substrate (160). The thin-film layer (190) may be included in electronics (58) formed on the substrate (160). The electronics (58) may provide electronic devices configured to sense or modify a property of the sample. The thin-film layer (190) defines an opening (188) for routing movement of fluid and/or sample within the device.
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公开(公告)号：EP1587626A1
公开(公告)日：2005-10-26
申请号：EP04706057.9
申请日：2004-01-28
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： PEASE, Grant , GHOZEIL, Adam, L. , DUNFIELD, John, Stephen , CHILDERS, Winthrop, D. , TYVOLL, David , SEXTON, Douglas, A. , CRIVELLI, Paul
CPC classification number: B01L7/525 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2200/147 , B01L2300/024 , B01L2300/0816 , B01L2300/0874 , B01L2300/1827 , B01L2300/1883 , B01L2400/0415 , Y10T436/11 , Y10T436/2575
Abstract: A microfluidic device (90) for analysis of a sample. The microfluidic device includes a substrate portion (94) that at least partially defines a chamber (102) for receiving the sample. The substrate portion (94) includes a substrate (98) having a surface (96). The substrate portion (94) also includes a plurality of thin-film layers (110) formed on the substrate (98) adjacent the surface (96). The thin-film layers (110) form a plurality of electronic devices. Each of at least two of the electronic devices is formed by a different set of the thin-film layers (110). The at least two electronic devices may include 1) a temperature control device for controlling the temperature of fluid in the chamber (102), and 2) an other electronic device configured to sense or modify a property of fluid in the chamber (102).
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