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    8.
    发明专利
    未知

    公开(公告)号：SE397523B

    公开(公告)日：1977-11-07

    申请号：SE7402667

    申请日：1974-02-28

    Applicant: HOECHST AG

    Inventor： ALLEN R C ,  ANDERSON V B

    IPC: C07D209/56 ,  A23K1/16 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/675 ,  A61P25/04 ,  A61P29/00 ,  C07C45/56 ,  C07C49/67 ,  C07C49/792 ,  C07C49/813 ,  C07C49/83 ,  C07C49/84 ,  C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/18 ,  C07D209/52 ,  C07D209/58 ,  C07D209/60 ,  C07D209/70 ,  C07D333/00 ,  C07D409/04 ,  C07F9/572 ,  C07D209/00

    Abstract: Novel N-phenylpyrroles are disclosed that are effective in the treatment of inflammation and pain in mammals and have the formula WHEREIN R is a hydrogen, alkyl of 1 to 6 carbon atoms, thienyl, phenyl or phenyl substituted by halogen, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 1 to 6 carbon atoms, alkanoylamino of 1 to 6 carbon atoms, nitro, cyano, hydroxyl, amino or phenyl; R1 is carboxyl, alkoxycarbonyl of 2 to 7 carbon atoms, carbamoyl, N-alkylcarbamoyl of 2 to 7 carbon atoms, N,N-dialkylcarbamoyl of 3 to 7 carbon atoms, hydroxycarbamoyl or dialkylphosphinylalkoxycarbonyl of 4 to 10 carbon atoms; R2 is hydrogen, hydroxyl, mercapto, halogen, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 1 to 6 carbon atoms, alkylthio of 1 to 6 carbon atoms, amino, alkylamino or 1 to 6 carbon atoms, dialkylamino of 2 to 6 carbon atoms, alkanoylamino of 1 to 6 carbon atoms, alkanoylthio of 1 to 6 carbon atoms, thiocarbamoyloxy, alkylthiocarbamoyloxy of 2 to 6 carbon atoms, dialkylthiocarbamoyloxy of 3 to 7 carbon atoms, carbamoylthio, alkylcarbamoylthio of 1 to 6 carbon atoms, dialkylcarbamoylthio of 2 to 7 carbon atoms, carbamoylamino, alkylcarbamoylamino of 2 to 6 carbon atoms or dialkylcarbamoylamino of 3 to 7 carbon atoms; R3 is hydrogen, alkanoyl of 1 to 6 carbon atoms, or phenyl; X is alkylene of 3 to 5 carbon atoms, alkylene of 3 to 5 carbon atoms substituted by alkyl or alkoxy of 1 to 6 carbon atoms, divinylene, divinylene substituted by alkyl of 1 to 6 carbon atoms, WHEREIN D is hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 1 to 6 carbon atoms, alkanoylamino of 1 to 6 carbon atoms, halogen, amino, nitro or trifluoromethyl; and n is 1 or 2.

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