公开(公告)号：NZ272704A

公开(公告)日：1997-02-24

申请号：NZ27270493

申请日：1993-12-23

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  BHATNAGAR NEERJA ,  BUENDIA JEAN ,  GRIFFOUL CHRISTINE

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：HUT67406A

公开(公告)日：1995-04-28

申请号：HU9400018

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  GRIFFOUL CHRISTINE ,  BHATNAGAR NEERJA ,  BUENDIA JEAN

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：PL301778A1

公开(公告)日：1994-07-11

申请号：PL30177894

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  BHATNAGAR NEERJA ,  BUENDIA JEAN ,  GRIFFOUL CHRISTINE

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：CA2112795A1

公开(公告)日：1994-07-07

申请号：CA2112795

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  BHATNAGAR NEERJA ,  BUENDIA JEAN ,  GRIFFOUL CHRISTINE

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04 ,  C07D405/10 ,  C07D317/14 ,  C07C65/30 ,  C07C43/307 ,  C07F9/38 ,  C07C205/44 ,  C07C47/55

Abstract: 1 Process for the preparation of biphenyl derivatives The invention relates to a process for the preparation of a compound of the formula (I) (I) in which X is an optionally protected formyl group and R is a group which is itself inert to the reaction conditions of the synthesis, which comprises reacting a compound of the formula (II) (II) where X is as defined above, with a substituted phenylhalogen compound of the formula (III) (III) where the substituent Hal is a halogen group and R is as defined above.

公开(公告)号：NO940023D0

公开(公告)日：1994-01-04

申请号：NO940023

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  BHATNAGAR NEERJA ,  BUENDIA JEAN ,  GRIFFOUL CHRISTINE

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04 ,  C07C

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：NO301878B1

公开(公告)日：1997-12-22

申请号：NO940023

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  BHATNAGAR NEERJA ,  BUENDIA JEAN ,  GRIFFOUL CHRISTINE

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：AU677247B2

公开(公告)日：1997-04-17

申请号：AU5302994

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  BHATNAGAR NEERJA ,  BUENDIA JEAN ,  GRIFFOUL CHRISTINE

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：SI9400003A

公开(公告)日：1994-09-30

申请号：SI9400003

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  BHATNAGAR NEERJA ,  BUENDIA JEAN ,  GRIFFOUL CHRISTINE

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04 ,  A61K31/275

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：SK694A3

公开(公告)日：1994-08-10

申请号：SK694

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  BHATNAGAR NEERJA ,  BUENDIA JEAN ,  GRIFFOUL CHRISTINE

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04 ,  A61K31/275

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：ZA9400018B

公开(公告)日：1994-08-18

申请号：ZA9400018

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  BHATNAGAR NEERJA ,  BUENDIA JEAN ,  GRIFFOUL CHRISTINE

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04 ,  C07C ,  A61K ,  C07D

CPC classification number: C07D257/04 ,  C07B37/04 ,  C07C67/343 ,  C07C253/30 ,  C07C303/40 ,  C07C311/09 ,  C07C311/51 ,  C07C311/58 ,  C07C69/76