公开(公告)号：KR850001781B1

公开(公告)日：1985-12-18

申请号：KR800003947

申请日：1980-10-14

Applicant: HOECHST AG

Inventor： BICKEL MARTIN ,  GEIGER ROLF ,  RAINER OBERMEIER ,  VOLKER TEETZ

IPC: C07K5/10

公开(公告)号：JPH1045624A

公开(公告)日：1998-02-17

申请号：JP13116097

申请日：1997-05-21

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  WAGNER ADALBERT ,  WIRTH KLAUS ,  HROPOT MAX ,  BICKEL MARTIN

IPC: A61K45/00 ,  A61K31/00 ,  A61K31/33 ,  A61K31/335 ,  A61K31/395 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61P43/00

Abstract: PROBLEM TO BE SOLVED: To carry out the treatment of chronic fibroplastic hepatopathy (hepatic cirrhosis or hepatic fibrosis), etc., by using a specific non-peptide bradykinin antagonistic agent. SOLUTION: This non-peptide bradykinin antagonistic agent is preferably a compound of formula I D is a group of formula II [X is N or C-R ; X is N or C-R ; X is N or C-R (R is H, a halogen, etc.; R is H or a 1-4C alkyl; R is H, a halogen, etc.)], etc.; E is a group of formula III [Q is O or NR (R is H or a 1-4C alkyl); A is a 1-3C alkanediyl; R and R are each H or a halogen; R is a group of formula IV (Y is a 2-6C alkenediyl; R and R are each H, a 1-5C alkyl, etc.)]; R and R are each H, a halogen, etc.} or its pharmaceutically permissible salt, e.g. N-[1-[4-(1,1-dimethylethyl) phenyl]methylpiperidine-4-yl]-8-methoxy-4-[[4-[[[1-(phenylmethyl)piper idine-4- yl]amino]carbonyl]phenyl]amino-3-quinoline carboxamide. The compound can be produced e.g. by a process including the deprotonization of a compound of formula V, etc.

公开(公告)号：JPH1017491A

公开(公告)日：1998-01-20

申请号：JP7293897

申请日：1997-03-26

Applicant: HOECHST AG

Inventor： BREIPOHL GERHARD ,  HENKE STEPHAN ,  KNOLLE JOCHEN ,  WIRTH KLAUS ,  HROPOT MAX ,  BICKEL MARTIN

IPC: A61K38/00 ,  A61K38/04 ,  A61K38/08 ,  A61K45/00 ,  A61P1/16 ,  A61P43/00 ,  C07K7/18

Abstract: PROBLEM TO BE SOLVED: To obtain the subject agent capable of being used for a medicine useful for treating chronic fibroplastic liver disease and acute liver diseases by using a bradykinin antagonist. SOLUTION: This medicine used for treating chronic fibroplastic liver diseases and acute liver diseases uses a bradykinin antagonist expressed by the formula: H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH (HOE-140), para- guanidobenzoyl-Arg-Pro-Hyp-Gly-Gly-Thi-Ser-D-Tic-Oic-Arg-OH, or physiologically permissible salt thereof. Further, a suitable bradykinin antagonist manifests a sodium excretion increasing effect in a CCl4 induced hepatic fibrosis model in rats. Thus, it is expected that the medicine can be used to perform the treatment of the chronic fibroplastic liver diseases (cirrhosis and hepatic fibrosis) and the acute liver diseases, and the prevention of complicating diseases, especially the prevention or the treatment of portal hypertension, incompensation phenomenon, etc.

公开(公告)号：UA41318C2

公开(公告)日：2001-09-17

申请号：UA94105979

申请日：1994-10-31

Applicant: HOECHST AG

Inventor： WEIDMANN KLAUS ,  BARINGHAUS KARL-HEINZ ,  TSCHANK GEORG ,  BICKEL MARTIN

Abstract: Винахідналежитьдоновиххімічнихречовинз ціннимифармакологічнимивластивостями, зокремадогетероциклічнихпохіднихкарбоновоїкислотизагальноїформули (I): (I) де: Q - кисень, сіркаабо NR', де R' означаєводеньабоарилз 6-12 атомамивуглецю; А - алкіленз 1-4 атомамивуглецю, незаміщенийабозаміщенийгрупою -О-[CH2]x-CfH(2f+1-g)Halg, де: хозначаєвід 0 до 3, f - від 1 до 8, g від - 0,1 до (2f+1), а Hal - галоїд, алкоксикарбоніломз 1-6 атомамивуглецюв алкільнійчастині, абофенилом; У - карбоксилабогрупа COOG, де: G представляєнерозгалуженийаборозгалуженийаліфатичнийалкілз 1-16 атомамивуглецю R1, R2 і R3 різніі означаютьводень, галоген, карбоксил, циклоалкілалкокси.

公开(公告)号：DE59209838D1

公开(公告)日：2000-06-29

申请号：DE59209838

申请日：1992-02-03

Applicant: HOECHST AG

Inventor： SCHUBERT GERRIT ,  BAADER EKKEHARD ,  BICKEL MARTIN ,  GUENZLER-PUKALL VOLKMAR

IPC: A61K31/44 ,  A61K31/4409 ,  A61K31/4427 ,  A61P7/02 ,  A61P37/06 ,  A61P43/00 ,  C07D213/04 ,  C07D257/04 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14

Abstract: The invention relates to 2,4- and 2,5-bis(tetrazolyl)pyridines. The said compounds inhibit the enzymes proline hydroxylase and lysine hydroxylase and cause selective inhibition of collagen biosynthesis. They are used as fibrosuppressants and immunosuppresants.

公开(公告)号：FI103881B1

公开(公告)日：1999-10-15

申请号：FI934303

申请日：1993-09-30

Applicant: HOECHST AG

Inventor： WEIDMANN KLAUS ,  BICKEL MARTIN ,  GUENZLER-PUKALL VOLKMAR ,  BAHRINGHAUS KARL-HEINZ

IPC: A61K31/4402 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/44 ,  A61P7/02 ,  A61P9/10 ,  A61P35/00 ,  C07D213/69 ,  C07D213/79 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89

Abstract: The invention relates to acylsulphonamido- and sulphonamidopyridine-2-carboxylic acid esters and their pyridine-N-oxides of the general formula I in which A = R and B = X-NR R or B = R and A = X-NR R . The compounds are suitable as medicaments against fibrotic diseases.

公开(公告)号：HK1011973A1

公开(公告)日：1999-07-23

申请号：HK98113073

申请日：1998-12-10

Applicant: HOECHST AG

Inventor： WEIDMANN KLAUS ,  BICKEL MARTIN ,  GUNZLER-PUKALL VOLKMAR

IPC: C07D213/81 ,  A61K31/44 ,  A61K31/4418 ,  A61P1/16 ,  A61P3/00 ,  A61P11/00 ,  A61P43/00 ,  C07D213/82 ,  C07D213/89 ,  C07D ,  A61K

Abstract: Sulphonamidocarbonyl pyridine-2-carboxylic acid ester amide derivs. of formula (I) and their pyridine N-oxides are new. R1 = OH or 1-6C alkoxy; R2, R3 = H, opt. substd. 1-6C alkyl, 1-6C alkoxy, halogen (esp. F, Cl or Br), CN, OH or NH2; R6 = H, 1-6C alkyl or a N-protecting gp., a 1-4 valent cation or a cation of a basic amino acid; R7 = Y-(Y'U)rDW but not SO3H; Y = SO2 or CO; Y' = bond or 1-16C alkanediyl, 3-10C cyclic alkanediyl, 2-16C alkenediyl, 2-16C cycloalkenediyl, 2-16C alkynediyl, 2-16C alkenynediyl, opt. contg. more than 1 C-C multiple bond; U = bond, H (sic), CO, OCO, COO, CONR, NRCO, O, SO, SO2, NR; R = 1-3C alkyl or H; r = 1-4; D = bond, H (sic), 1-10C alkanediyl, 1-10C alkenediyl, 2-10C alkynediyl, 2-10C alkenynediyl, opt. contg. more than one C-C multiple bond; W = bond (sic), H, 3-10C cycloaliphatic alkyl, 3-10C alkenyl, 3-10C alkynyl or 3-10C alkenynyl, 6-16C aryl or 5-6 membered heteroaryl; R4 = H, 1-6C alkyl, Ph or phenyl(1-4C)alkyl; R5 = aliphatic 1-8C alkyl, (mono-substd. by 1-12C alkoxycarbonyl, 1-12C alkoxy(1-2C)alkoxycarbonyl, 3-8C cycloalkoxycarbonyl, 3-12C alkenyloxycarbonhyl, or 3-12C alkynyloxycarbonyl), and which is opt. substd. with one or more substitutents (sic); with provisos.

公开(公告)号：SG65705A1

公开(公告)日：1999-06-22

申请号：SG1997004280

申请日：1997-12-03

Applicant: HOECHST AG

Inventor： WEIDMANN KLAUS ,  BARINGHAUS KARL-HEINZ ,  TSCHANK GEORG ,  BICKEL MARTIN

IPC: C07D213/64 ,  A61K31/44 ,  A61P9/10 ,  A61P11/00 ,  A61P43/00 ,  C07D213/69 ,  C07D213/81

Abstract: N-(Esterified carboxyalkyl)-3-hydroxypyridine-2-carboxamide derivatives of formula (I) and their salts, excluding 3-Hydroxypyridine-2-carboxylic acid (glycyl ethyl ester)-amide (I'), are new. A = CH2 or CHMe; G = organic residue such that (I) is a pro-drug. Also claimed is use of (I), including (I'), as given below (see '

公开(公告)号：FI102895B

公开(公告)日：1999-03-15

申请号：FI931250

申请日：1993-03-22

Applicant: HOECHST AG

Inventor： WEIDMANN KLAUS ,  BICKEL MARTIN ,  GUENZLER-PUKALL VOLKMAR

IPC: A61K31/4402 ,  A61K31/4412 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/4427 ,  A61P3/00 ,  A61P7/04 ,  C07D213/81 ,  C07D213/82 ,  C07D213/83 ,  C07D213/89 ,  C07D401/12 ,  C07D409/12

公开(公告)号：SK596189A3

公开(公告)日：1998-12-02

申请号：SK596189

申请日：1989-10-20

Applicant: HOECHST AG

Inventor： BAL-TEMBE SWATI ,  BLUMBACH JURGEN ,  DOHADWALLA ALIHUSSEIN N ,  LAL BANSI ,  PUNEKAR NARAYAN S ,  RAJGOPALAN RAMANUJAM ,  RUPP RICHARD H ,  BICKEL MARTIN

IPC: C07D295/08 ,  A61K31/445 ,  C07D211/36 ,  C07D295/088 ,  C07D295/092

Abstract: Compounds of the formula III in which R4 - R6 have the given meaning, have a spasmolytic activity.