公开(公告)号：ES2136669T3

公开(公告)日：1999-12-01

申请号：ES94100048

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  BHATNAGAR NEERJA DR ,  BUENDIA JEAN DR ,  GRIFFOUL CHRISTINE DR

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：CZ1494A3

公开(公告)日：1994-08-17

申请号：CZ1494

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  BHATNAGAR NEERJA DR ,  BUENDIA JEAN DR ,  GRIFFOUL CHRISTINE DR

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：AT183732T

公开(公告)日：1999-09-15

申请号：AT94100048

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  BHATNAGAR NEERJA DR ,  BUENDIA JEAN DR ,  GRIFFOUL CHRISTINE DR

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：DK0606065T3

公开(公告)日：2000-03-13

申请号：DK94100048

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  BHATNAGAR NEERJA DR ,  BUENDIA JEAN DR ,  GRIFFOUL CHRISTINE DR

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：GR3031852T3

公开(公告)日：2000-02-29

申请号：GR990402946

申请日：1999-11-17

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  BHATNAGAR NEERJA DR ,  BUENDIA JEAN DR ,  GRIFFOUL CHRISTINE DR

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：CZ9400014A3

公开(公告)日：1994-08-17

申请号：CZ1494

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  BHATNAGAR NEERJA DR ,  BUENDIA JEAN DR ,  GRIFFOUL CHRISTINE DR

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04

CPC classification number: C07D257/04 ,  C07B37/04 ,  C07C67/343 ,  C07C253/30 ,  C07C303/40 ,  C07C311/09 ,  C07C311/51 ,  C07C311/58 ,  C07C69/76