公开(公告)号：KR790000003B1

公开(公告)日：1979-02-26

申请号：KR740002736

申请日：1974-06-13

Applicant: HOECHST AG

Inventor： DUEWEL D ,  URBANIETZ J ,  LOEWE H ,  KIRSCH R

Abstract: Approx. 40 2-(Alkoxycarbonylamino) benzimidazole-5(6)-ylphenylethers(I ; R1 = C1-4 alkyl. R2,R3 = same or different H, OH, C1-4 alkoxy, halogen, trifluoromethyl, C1-4 alkyl, or C1-4 ! alkoxy contg. carboalkoxy. R4 = H or Cl atom.X = O or S), as anthelmintics, were prepd.via refluxing 3,4-diamino-diphenyl-ether with bis-methylthio-methylene-aminomethyl-formate in THF. These anthelmintics are specially effective for strongylides.

公开(公告)号：KR790001340B1

公开(公告)日：1979-09-27

申请号：KR750000704

申请日：1975-04-04

Applicant: HOECHST AG

Inventor： LOEWE H ,  DUEWEL D ,  URBANIETZ J ,  KIRSCH R

Abstract: Title compds (I; R1 = C1,-C4 alkyl, R2,R3 = H, OH, C1-C4 alkoxy, halogen, etc.) useful as anthelmintic, were prepd. by condensating O-phenylenediamine (II) (a) with alkyl-s-methylthiourea carboxylate(III) at pH 2-5, or (b) with NCNHCOOR1 at pH2-5, or treating II (c) with R1 CO2NCCl2 at-10-40≦̸C in the presence of base, (d) with bis-aryl (or alkyl)-thiomethylene-amino- formates (VI; R4 and/or R5 = C1-C4 alkyl, C3-C5 alkenyl, cycloalkyl, etc.).

公开(公告)号：KR790000162B1

公开(公告)日：1979-03-24

申请号：KR740002797

申请日：1974-06-17

Applicant: HOECHST AG

Inventor： KIRSCH R ,  LOEWE H ,  DUEWEL D ,  URBANIETZ J

Abstract: Approx. 40 anthelmintics (I; R1 = alkyl, Ph, R2 and R3 = H, OH, alkoxy, halogen, trifluoromethyl, alkyl, R4 = H, Cl, X = O,S) were prepd. by refluxing 2-amino-benzimidazole with R1O-CO-OR5 (R1 and R3 = alkyl, Ph) in THF. Thus, 5-phenoxy-benzimidazole-2-methylcarbamate was prepd. by reaction of 41.5g 2-amino-5-phenoxy-benzimidazole with 16.5g CH3ONa and 22.5g CO(OCH3)2 in 300ml THF and neutralized with HCl.

公开(公告)号：KR820001846B1

公开(公告)日：1982-10-15

申请号：KR790003814

申请日：1979-11-01

Applicant: HOECHST AG

Inventor： LOEWE H ,  DUEWEL D ,  KIRSCH R ,  GOSET URBANIETZ

IPC: C07D285/16 ,  C07C125/02

Abstract: R1 = C1-4 alkyl; R2,R3 = H, C1-4 alkoxy, halo, CF3, C1-4 alkyl, cyano; X = -O-SO2-, -SO2-O-) use ful as intermediates of anthelmintic agent, were prepd. by reaction of II and III. Thus, III(R2,R3 = H, X = -O-SO2-) in IV(R1 = Me) was heated at 100 ≦̸C, 1 hr to give 25 g II, which was treated with sodium dithionate to give I(R4 = H; n = 0).

公开(公告)号：KR810000233B1

公开(公告)日：1981-03-23

申请号：KR760001501

申请日：1976-06-16

Applicant: HOECHST AG

Inventor： DUEWEL D ,  LOEVE H ,  URBANIETE J

IPC: A61K31/54 ,  C07D285/16

Abstract: Title compds. (I; R1 - C1-4 alkyl; R2, R3 = H,C1-4 alkoxy, halogen, trifluoromethyl, C1-4 alkyl or cyano; R4 = H, C2-4 acyl of benzoyl; n = 0 or 1; X= -O-SO2 or -SO2-O-), useful as anthelmintics, were manufd. by condensation of II with alkaline metals dithionite in alkaline soln. I is especially effective in hibernant, wireworm, tapeworm, and mawworm.

公开(公告)号：US3808261A

公开(公告)日：1974-04-30

申请号：US4394970

申请日：1970-06-05

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  DUEWEL D ,  KOENIG J

IPC: A61K31/165 ,  A23K1/16 ,  A61K31/22 ,  A61K31/245 ,  A61P33/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/56 ,  C07C235/64 ,  C07D307/68 ,  F23Q7/02 ,  F24C5/14 ,  C07C103/22

CPC classification number: A61K31/245 ,  C07D307/68 ,  Y10S514/893

Abstract: IN WHICH X REPRESENTS HYDROGEN OR HALOGEN, R1 REPRESENTS 1 TO 3 NITRO GROUPS, TRIFLUOROMETHYL GROUPS AND/ OR HALOGEN ATOMS, R2 REPRESENTS HYDROGEN; LOWER ALKYL WHICH MAY BE SUBSTITUTED BY HALOGEN, LOWER ALKOXY OR PHENYL; ALKENYL HAVING 3 TO 6 CARBON ATOMS; CYCLOALKYL HAVING 4 TO 6 CARBON ATOMS; PHENYL; AN UNSATURATED HETEROCYCLIC 5OR 6-MEMBERED RING; ALKYL-AMINO OR DIALKYL-AMINO IN WHICH THE ALKYL GROUPS EACH CONTAIN 1 TO 4 CARBON ATOMS OR MAY FORM TOGETHER WITH THE NITROGEN ATOM A PYYROLIDINE, PIPERIDINE, MORPHOLINE OR N-MERHTHYL-PIPERAZINE RING.
DIACYLOXY-BENZOIC ACID ANILIDES OF THE GENERAL FORMULA

1-(NO2-),2,4-DI(R2-COO-),3-((R1-PHENYL)-NH-CO-),5-X-

BENZENE

公开(公告)号：KR780000752B1

公开(公告)日：1978-12-30

申请号：KR740002737

申请日：1974-06-13

Applicant: HOECHST AG

Inventor： DUEWEL D ,  LOEWE H ,  KIRSCH R ,  URBANIETZ J

公开(公告)号：KR780000116B1

公开(公告)日：1978-04-15

申请号：KR720001961

申请日：1972-12-26

Applicant: HOECHST AG

Inventor： KIRSCH R ,  LOEWE H ,  DUEWEL D ,  URBANIETZ J

IPC: C07D235/30 ,  A23K1/16 ,  C07D235/32

公开(公告)号：ZA794355B

公开(公告)日：1980-08-27

申请号：ZA794355

申请日：1979-08-17

Applicant: HOECHST AG

Inventor： KIRSCH R ,  LOEWE H ,  URBANIETZ J ,  DUEWEL D

IPC: A61K31/27 ,  A61P33/00 ,  C07C67/00 ,  C07C301/00 ,  C07C303/30 ,  C07C309/72 ,  C07C309/73 ,  C07C309/75 ,  C07C ,  A61K

Abstract: New monocarboxylates of phenylguanidinesulfonic acid esters and a process for their manufacture are described. They are effective as medicaments against helminths and liver flukes when administered orally or parenterally.

公开(公告)号：NZ182087A

公开(公告)日：1979-08-31

申请号：NZ18208776

申请日：1976-09-17

Applicant: HOECHST AG

Inventor： URBANIETZ J ,  LOEWE H ,  KIRSCH R ,  DUEWEL D

IPC: A61K31/54 ,  A61P33/00 ,  A61P33/10 ,  C07D285/16