公开(公告)号：PT812844E

公开(公告)日：2003-03-31

申请号：PT97108870

申请日：1997-06-03

Applicant: HOECHST AG

Inventor： RUDOLPHI KARL ,  GEBERT ULRICH ,  ERHARD WOLF DR ,  ELISABETH DEFOSSA DR ,  UWE HEINELT DR ,  DB HIRISTO ANAGNOSTOPULOS ,  JOHN J GROME DR

IPC: C07D473/04 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P7/08 ,  A61P9/00 ,  A61P9/10 ,  A61P31/04 ,  A61P31/12 ,  A61P43/00 ,  C07D473/06

Abstract: The use of at least one theophylline 1-ether analogue of formula (I) or its diastereoisomer or salt is claimed for the preparation of a medicament for the treatment and/or prophylaxis of shock states. R1 = 1-5C alkyl or (1-2C)alkoxy-(1-3C) alkyl; or phenyl or phenyl-(1-2C)alkyl (both optionally mono- or dihalo-substituted in the ring); A = 1-4C alkylene; R2 = 1-5C alkyl, 3-6C cycloalkyl, 4-8C cycloalkyl, phenyl or phenyl-(1-2C)alkyl. Compounds (I) and their stereoisomers and salts are new, with the exception of compounds in which (a) R2 = n-propyl, R1= Me or Et and A = CH2CH2 or (b) R2 = n-propyl, R1 = Me and A = (CH2)3. Certain intermediates in the preparation of (I) are also new.