公开(公告)号：DE59310018D1

公开(公告)日：2000-05-31

申请号：DE59310018

申请日：1993-09-24

Applicant: HOECHST AG

Inventor： GEHRMANN MATHIAS ,  SEEMANN GERHARD ,  BOSSLET KLAUS ,  CZECH JOERG

IPC: A01K67/027 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/705 ,  C07K16/00 ,  C07K16/18 ,  C07K19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/24 ,  C12N15/09 ,  C12N15/62 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865 ,  G01N33/53 ,  G01N33/68

Abstract: The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolise a compound which has little or no cytotoxicity (prodrug) into a cytotoxic compound (drug), where the antigen binding region consists of a single polypeptide chain. Covalently bonded carbohydrates are advantageously present on the polypeptide chain.

公开(公告)号：ES2147189T3

公开(公告)日：2000-09-01

申请号：ES93115418

申请日：1993-09-24

Applicant: HOECHST AG

Inventor： GEHRMANN MATHIAS ,  SEEMANN GERHARD ,  BOSSLET KLAUS ,  CZECH JOERG

IPC: A01K67/027 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/705 ,  C07K16/00 ,  C07K16/18 ,  C07K19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/24 ,  C12N15/09 ,  C12N15/62 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865 ,  G01N33/53 ,  G01N33/68

Abstract: The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolise a compound which has little or no cytotoxicity (prodrug) into a cytotoxic compound (drug), where the antigen binding region consists of a single polypeptide chain. Covalently bonded carbohydrates are advantageously present on the polypeptide chain.

公开(公告)号：AT192193T

公开(公告)日：2000-05-15

申请号：AT93115418

申请日：1993-09-24

Applicant: HOECHST AG

Inventor： GEHRMANN MATHIAS ,  SEEMANN GERHARD ,  BOSSLET KLAUS ,  CZECH JOERG

IPC: A01K67/027 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/705 ,  C07K16/00 ,  C07K16/18 ,  C07K19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/24 ,  C12N15/09 ,  C12N15/62 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865 ,  G01N33/53 ,  G01N33/68

Abstract: The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolise a compound which has little or no cytotoxicity (prodrug) into a cytotoxic compound (drug), where the antigen binding region consists of a single polypeptide chain. Covalently bonded carbohydrates are advantageously present on the polypeptide chain.

公开(公告)号：DK0590530T3

公开(公告)日：2000-08-21

申请号：DK93115418

申请日：1993-09-24

Applicant: HOECHST AG

Inventor： GEHRMANN MATHIAS ,  SEEMANN GERHARD ,  BOSSLET KLAUS ,  CZECH JOERG

IPC: A01K67/027 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/705 ,  C07K16/00 ,  C07K16/18 ,  C07K19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/24 ,  C12N15/09 ,  C12N15/62 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865 ,  G01N33/53 ,  G01N33/68 ,  A61K37/02 ,  C07K15/28

Abstract: The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolise a compound which has little or no cytotoxicity (prodrug) into a cytotoxic compound (drug), where the antigen binding region consists of a single polypeptide chain. Covalently bonded carbohydrates are advantageously present on the polypeptide chain.