公开(公告)号：DE1136714B

公开(公告)日：1962-09-20

申请号：DEF0026732

申请日：1958-10-04

Applicant: HOECHST AG

Inventor： EHRHART DR GUSTAV ,  HENNIG DR INGEBORG ,  LINDNER DR ERNST ,  OTT HEINRICH

IPC: C07C233/16

公开(公告)号：DE1104497B

公开(公告)日：1961-04-13

申请号：DEF0028824

申请日：1958-05-07

Applicant: HOECHST AG

Inventor： EHRHART DR GUSTAV ,  HENNIG DR INGEBORG ,  LINDNER DR ERNST ,  OTT HEINRICH

IPC: C07C233/00

公开(公告)号：DE1181232B

公开(公告)日：1964-11-12

申请号：DEF0032509

申请日：1960-11-10

Applicant: HOECHST AG

Inventor： HENNIG DR INGEBORG ,  LINDNER DR ERNST

IPC: C07C29/147 ,  C07C33/24

公开(公告)号：DE1133395B

公开(公告)日：1962-07-19

申请号：DEF0032535

申请日：1960-11-12

Applicant: HOECHST AG

Inventor： HENNIG DR INGEBORG ,  LINDNER DR ERNST

Abstract: The invention comprises compounds of the general formula (wherein R represents a phenyl group, which may be substituted by a C1- 4 alkyl or alkoxy radical, or a benzyl group) and physiologically tolerable acid addition salts thereof, pharmaceutical preparations containing them, and their preparation by (a) reducing phenylacetone in the presence of an amine of the formula (I) or reacting phenylacetone with the amine and reducing the product, (b) reacting an amine (I) with a 1-phenyl-2-halopropane or 1 - phenyl - 2-halopropene and hydrogenating the aliphatic double bond (if present) in the product, (c) reacting a halide of the formula (wherein Hal represents a halogen atom) with 1-phenyl-2-aminopropane, (d) reducing an aldehyde of the formula in the presence of 1-phenyl-2-aminopropane, or reacting the aldehyde with 1-phenyl-2-aminopropane and reducing the product, or (e) reducing an amide of the formula optionally followed in each case by acid addition salt formation. The starting materials are prepared by standard methods. The compounds of the invention exhibit heart and blood circulation activity, and may be administered orally or parenterally in the form of pharmaceutical preparations (e.g. tablets, dragees and solutions) containing them together with a carrier.

公开(公告)号：DE1122939B

公开(公告)日：1962-02-01

申请号：DEF0026366

申请日：1958-08-08

Applicant: HOECHST AG

Inventor： SCHMITT DR KARL ,  HENNIG DR INGEBORG ,  LINDNER DR ERNST ,  OTT HEINRICH

公开(公告)号：DE952804C

公开(公告)日：1956-11-22

申请号：DEF0016373

申请日：1954-12-16

Applicant: HOECHST AG

Inventor： EHRHART DR GUSTAV ,  HENNIG DR INGEBORG

IPC: C07C303/26 ,  C07C309/65

公开(公告)号：DE1156813B

公开(公告)日：1963-11-07

申请号：DEF0031730

申请日：1960-07-22

Applicant: HOECHST AG

Inventor： HENNIG DR INGEBORG ,  LINDNER DR ERNST

IPC: C07D209/14

公开(公告)号：DE1114180B

公开(公告)日：1961-09-28

申请号：DEF0026367

申请日：1958-08-08

Applicant: HOECHST AG

Inventor： EHRHART DR GUSTAV ,  HENNIG DR INGEBORG ,  LINDNER DR FRITZ ,  OTT HEINRICH

IPC: C07C233/00

公开(公告)号：DE1111167B

公开(公告)日：1961-07-20

申请号：DEF0030335

申请日：1959-07-08

Applicant: HOECHST AG

Inventor： HENNIG DR INGEBORG ,  LINDNER DR ERNST ,  OTT HEINRICH

IPC: C07C233/00

公开(公告)号：DE1076706B

公开(公告)日：1960-03-03

申请号：DEF0019915

申请日：1956-03-29

Applicant: HOECHST AG

Inventor： HENNIG DR INGEBORG

IPC: C07C233/00 ,  C07C233/16