公开(公告)号：JPH1072463A

公开(公告)日：1998-03-17

申请号：JP16581597

申请日：1997-06-23

Applicant: HOECHST AG

Inventor： BOGER HANS GEORG ,  HOFFMANN AXEL ,  JAHNE GERHARD ,  SCHAFER HANS-LUDWIG ,  KRASS NORBERT

IPC: A61K31/505 ,  A61P3/06 ,  C07D403/04

Abstract: PROBLEM TO BE SOLVED: To obtain a novel compound which can manifest sufficient antihyperlipemic action with (almost) no cytotoxicity and is useful for treatment of liposis and disorder of lipid metabolism. SOLUTION: This novel compound is represented by formula I [R is H, an (F-substituted) 1-8C alkyl; R is an -O-F-substituted 1-8C alkyl, an -S-F- substituted 1-8C alkyl; R is H, F, Cl, Br, R and R may be incorporated to form an -O-F-substituted 1-5C alkylene-O-] or its acid adduct, typically 4- amino-2-(4,4-dimethylimidazolidin-2-one-1-yl)-5-[N-methly-N-(2-trifluo romethoxy) phenyl]pyrimidine-carboxamide. The compound of formula I is prepared by converting 4-amino-2-(4,4-dimethylimidazolidin-2-one-1-yl)-5-carboxylic acid to its acid chloride followed by reaction of the acid chloride with a compound of formula II.

公开(公告)号：CA2208611A1

公开(公告)日：1997-12-24

申请号：CA2208611

申请日：1997-06-23

Applicant: HOECHST AG

Inventor： HOFFMANN AXEL ,  KRASS NORBERT ,  LEINEWEBER MICHAEL ,  RACKUR GERHARD ,  B GER HANS GEORG

IPC: A61K31/505 ,  A61P3/06 ,  C07D403/04 ,  C07D403/14

Abstract: 4-Amino-2-ureidopyrimidine-5-carboxamides processes for their preparation pharmaceuticals comprising these compounds and their use Tertiary 4-amino-2-ureidopyrimidine-5-carboxamides of the formula I (see fig. I) in which R1 to R4 have the meanings indicated and also their physiologically tolerable salts and a process for their preparation are described. The compoundsare suitable for the treatment of disorders of lipid metabolism.

公开(公告)号：NO972942D0

公开(公告)日：1997-06-23

申请号：NO972942

申请日：1997-06-23

Applicant: HOECHST AG

Inventor： RACKUR GERHARD ,  BOEGER HANS GEORG ,  KRASS NORBERT ,  HOFFMANN AXEL ,  LEINEWEBER MICHAEL

IPC: A61K31/505 ,  A61P3/06 ,  C07D403/04 ,  C07D403/14

Abstract: 4-Amino-2-imidazolidinonyl-pyrimidin-5-carboxamide derivatives of formula (I), and their salts, are new. R1 = 1-8C alkyl; R2, R3 = F, Cl, Br, H, 1-8C alkoxy or 1-8C alkylthio; R4 = CF3 or OCF3; all alkyl groups are optionally substituted by 1 or more F.

公开(公告)号：DE19625089A1

公开(公告)日：1998-01-02

申请号：DE19625089

申请日：1996-06-24

Applicant: HOECHST AG

Inventor： BOGER HANS GEORG ,  HOFFMANN AXEL ,  JAHNE GERHARD ,  SCHAFER HANS-LUDWIG ,  KRASS NORBERT

IPC: A61K31/505 ,  A61P3/06 ,  C07D403/04 ,  C07D405/14

Abstract: 4-Amino-2-imidazolidinonyl-pyrimidin-5-carboxamide derivatives of formula (I), and their salts, are new. R1 = H or 1-8C alkyl; Ar = phenyl substituted by R2 and R3; R2 = F, Cl, Br, H, 1-8C alkoxy or 1-8C alkylthio; R3 = 1-8C alkoxy or 1-8C alkylthio; or R2+R3 = 1-5C alkylene dioxy; all alkyl groups are optionally substituted by 1 or more F.

公开(公告)号：NO972943A

公开(公告)日：1997-12-29

申请号：NO972943

申请日：1997-06-23

Applicant: HOECHST AG

Inventor： BOEGER HANS GEORG ,  HOFFMANN AXEL ,  JAEHNE GERHARD ,  KRASS NORBERT ,  SCHAEFER HANS-LUDWIG

IPC: A61K31/505 ,  A61P3/06 ,  C07D403/04

CPC classification number: C07D403/04

公开(公告)号：CA2208630A1

公开(公告)日：1997-12-24

申请号：CA2208630

申请日：1997-06-23

Applicant: HOECHST AG

Inventor： B GER HANS GEORG ,  KRASS NORBERT ,  SCH FER HANS-LUDWIG ,  HOFFMANN AXEL ,  J HNE GERHARD

IPC: A61K31/505 ,  A61P3/06 ,  C07D403/04 ,  C07D405/14

Abstract: 4-Amino-2-ureidopyrimidine-5-carboxamides, processes for their preparation, pharmaceuticals comprising these compounds, and their use 4-Amino-2-ureidopyrimidine-5-carboxamides of the formula I I in which R1 to R3 have the meanings indicated, and also their physiologically tolerable salts and a process for their preparation are described. The compoundsare suitable for the treatment of disorders of lipid metabolism.

公开(公告)号：CA2208630C

公开(公告)日：2006-07-11

申请号：CA2208630

申请日：1997-06-23

Applicant: HOECHST AG

Inventor： BOGER HANS GEORG ,  HOFFMANN AXEL ,  JAHNE GERHARD ,  SCHAFER HANS-LUDWIG ,  KRASS NORBERT

IPC: C07D403/04 ,  A61K31/505 ,  A61P3/06 ,  C07D405/14

Abstract: 4-Amino-2-ureidopyrimidine-5-carboxamides of the formula I (see formula I) in which R1 to R3 have the meanings indicated, and also their physiologicall y tolerable salts and a process for their preparation are described. The compounds are suitable for the treatment of disorders of lipid metabolism.

公开(公告)号：NO972942A

公开(公告)日：1997-12-29

申请号：NO972942

申请日：1997-06-23

Applicant: HOECHST AG

Inventor： RACKUR GERHARD ,  BOEGER HANS GEORG ,  KRASS NORBERT ,  HOFFMANN AXEL ,  LEINEWEBER MICHAEL

IPC: A61K31/505 ,  A61P3/06 ,  C07D403/04 ,  C07D403/14

CPC classification number: C07D403/04 ,  C07D403/14

公开(公告)号：NO972943D0

公开(公告)日：1997-06-23

申请号：NO972943

申请日：1997-06-23

Applicant: HOECHST AG

Inventor： BOEGER HANS GEORG ,  HOFFMANN AXEL ,  JAEHNE GERHARD ,  KRASS NORBERT ,  SCHAEFER HANS-LUDWIG

IPC: A61K31/505 ,  A61P3/06 ,  C07D403/04

Abstract: 4-Amino-2-imidazolidinonyl-pyrimidin-5-carboxamide derivatives of formula (I), and their salts, are new. R1 = H or 1-8C alkyl; Ar = phenyl substituted by R2 and R3; R2 = F, Cl, Br, H, 1-8C alkoxy or 1-8C alkylthio; R3 = 1-8C alkoxy or 1-8C alkylthio; or R2+R3 = 1-5C alkylene dioxy; all alkyl groups are optionally substituted by 1 or more F.

公开(公告)号：NO312414B1

公开(公告)日：2002-05-06

申请号：NO972943

申请日：1997-06-23

Applicant: HOECHST AG

Inventor： BOEGER HANS GEORG ,  HOFFMANN AXEL ,  JAEHNE GERHARD ,  KRASS NORBERT ,  SCHAEFER HANS-LUDWIG

IPC: A61K31/505 ,  A61P3/06 ,  C07D403/04 ,  A61K31/506

Abstract: 4-Amino-2-imidazolidinonyl-pyrimidin-5-carboxamide derivatives of formula (I), and their salts, are new. R1 = H or 1-8C alkyl; Ar = phenyl substituted by R2 and R3; R2 = F, Cl, Br, H, 1-8C alkoxy or 1-8C alkylthio; R3 = 1-8C alkoxy or 1-8C alkylthio; or R2+R3 = 1-5C alkylene dioxy; all alkyl groups are optionally substituted by 1 or more F.