公开(公告)号：US3751448A

公开(公告)日：1973-08-07

申请号：US3751448D

申请日：1972-01-19

Applicant: HOECHST AG

Inventor： JAGER G ,  GEIGER R ,  MUSCHAWECK R

IPC: C07D20060101 ,  C07D29/26

Abstract: BASICALLY SUBSTITUTED ISOBORNYL URETHANES OF THE GENERAL FORMULA I

IB-OOC-NH-CH2-CH(-R)-CH2-N
IN WHICH IB REPRESENTS THE ISOBRONYL RADICAL, R REPRESENTS HYDROGEN OR THE OH-GROUP, R1 AND R2 REPRESENTS AN ALKYL RADICAL HAVING 1 TO 4 CARBON ATOMS OR N, R1, R2 REPRESENT THE PYRROLIDINO OR PIPERIDINO RADICAL AND THEIR SALTS WITH PHYSIOLOGICALLY TOLERATED ACIDS, HAVING LOCAL ANAESTHETIC ACTION.

公开(公告)号：US3775466A

公开(公告)日：1973-11-27

申请号：US12542671

申请日：1971-03-17

Applicant: HOECHST AG

Inventor： JAGER G ,  GEIGER R

IPC: A61K38/00 ,  C07K1/06 ,  C07K1/12 ,  C07K5/02 ,  C07K5/09 ,  C07K5/097 ,  C07K5/103 ,  C07K5/107 ,  C07K14/695 ,  C07C133/10 ,  C07C125/04

CPC classification number: C07K5/0823 ,  A61K38/00 ,  C07K1/062 ,  C07K1/063 ,  C07K1/064 ,  C07K1/068 ,  C07K1/12 ,  C07K5/0215 ,  C07K5/0815 ,  C07K5/1005 ,  C07K5/1016 ,  C07K14/695

Abstract: ISOBORNYLOXYCARBONYLAMINO ACIDS AND DERIVATIVES THEREOF, PARTICULARLY NA-BENZYLOXYCARBONYL-NG,NG-BIS - (ISOBORONYLOXYCARBONYL)ARGININE, NG,NG-BIS-(ISOBORONYOXYCARBONYL)-ARGININE, AND NG,NG,NG-TRIS-(ISOBORONYLOXYCARBONYL)-ARGINIE, USEFUL AS INTERMEDIATES IN THE SYNTHESIS OF PEPTIDES, PREPARED BY REACTING AN AMINO ACID OR DERIVATIVES THEREOF EITHER WITH ISOBORONYLOXYCARBONYL CHLORIDE OR WITH AN ISOBORONYLOXYCARBONYL ACTIVE ESTER.

公开(公告)号：US3738978A

公开(公告)日：1973-06-12

申请号：US3738978D

申请日：1971-03-17

Applicant: HOECHST AG

Inventor： JAGER G ,  GEIGER R

IPC: A61K38/00 ,  C07K1/06 ,  C07K1/12 ,  C07K5/072 ,  C07K5/09 ,  C07K5/097 ,  C07K5/103 ,  C07K5/107 ,  C07K14/695 ,  C07C103/52 ,  C07G7/00

CPC classification number: C07K5/0823 ,  A61K38/00 ,  C07K1/062 ,  C07K1/063 ,  C07K1/064 ,  C07K1/068 ,  C07K1/12 ,  C07K5/06095 ,  C07K5/0815 ,  C07K5/1008 ,  C07K5/1013 ,  C07K5/1016 ,  C07K14/695

Abstract: METHOD OF MAKING AN N-ISOBORNYLOXYCARBONYL DERIVATIVE OF AN AMINO ACID, IMINO ACID, OR PEPTIDE BY REACTION THEREOF WITH ISOBORNYLOXYCARBONYL CHLORIDE OR WITH AN ACTIVE ISOBORNYLOXYCARBONYL ESTER. IMPROVED METHOD OF SYNTHESIZING A PEPTIDE BY REACTION OF AN N-ISOBORNYLOXYCARBONYL-AMINO OR -IMINO ACID OR PEPTIDE HAVING A FREE CARBOXY GROUP WITH AN AMINO OR IMINO ACID OR PEPTIDE HAVING A FREE AMINO GROUP. IMPROVED METHOD OF SYNTHESIZING A PEPTIDE BY REACTION OF THE FREE AMINO GROUP OF NG-DI-ISOBORNYLOCYCARBONYLARGININE, OR OF A PEPTIDE CONTAINING NG-DI-ISOBORNYLOCYCARBONYL-ARGININE WITH AN AMINO OR IMINO ACID OR PEPTIDE HAVING A FREE CARBOXY GROUP.