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1.发明授权Method of synthesizing peptides in the presence of a carbodiimide and a 1-hydroxy-benzotriazole 失效碳二亚胺和1-羟基苯并噻唑存在下合成肽的方法
公开(公告)号：US3725380A
公开(公告)日：1973-04-03
申请号：US3725380D
申请日：1970-04-01
Applicant: HOECHST AG
IPC: A61K38/00 , C07D249/18 , C07K1/10 , C07C103/52
CPC classification number: C07D249/18 , A61K38/00 , C07K1/10
Abstract: Improved synthesis of peptides by the carbodiimide method in which an amino-protected amino acid or peptide having a reactive carboxy group is condensed with a carboxy-protected amino acid or peptide having a reactive amino group in the presence of a 1hydroxy-benzotriazole or a substituted 1-hydroxy-benzotriazole of the formula
AS WELL AS IN THE PRESENCE OF A CARBODIIMIDE SUCH AS DICYCLOHEXYL CARBODIIMIDE.Abstract translation: 通过碳二亚胺方法改进肽的合成，其中具有反应性羧基的氨基保护的氨基酸或肽与羧基保护的氨基酸或具有反应性氨基的肽在1-羟基 - 苯并三唑存在下缩合，或 一种具有下式的取代的1-羟基 - 苯并三唑：作为二羧酸二碳酰亚胺的碳二亚胺存在。
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2.发明授权N omega-4,4-dimethoxybenzhydryl derivatives of asparagine and glutamine 失效阿司匹林和谷氨酰胺的N OMEGA-4,4-二甲氧基苄基衍生物
公开(公告)号：US3790618A
公开(公告)日：1974-02-05
申请号：US3790618D
申请日：1971-04-21
Applicant: HOECHST AG
IPC: C07C271/22 , C07K1/06 , C07C103/32
CPC classification number: C07C271/22 , C07K1/066 , Y10S930/15
Abstract: NW-4,4''-DIMETHOXYBENZYL-PROTECTED ASPARAGINE AND GLUTAMINE COMPOUNDS USEFUL AS INTERMEDIATES IN THE SYNTHESIS OF THERAPEUTICS BY PEPTIDE CONDENSATION REACTIONS.
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3.发明授权Method of synthesizing peptides in the presence of a carbodiimide and of 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine 失效碳二亚胺和3-羟基-4-氧代-3,4-二氢-1,2-2,3-苯并噻嗪的合成方法
公开(公告)号：US3795666A
公开(公告)日：1974-03-05
申请号：US3795666D
申请日：1970-07-28
Applicant: HOECHST AG
IPC: A61K38/00 , C07D253/08 , C07K1/10 , C07K5/068 , C07K14/695 , C07C103/52 , C07G7/00 , C08H1/00
CPC classification number: C07D253/08 , A61K38/00 , C07K1/10 , C07K5/06086 , C07K14/695 , Y02P20/55
Abstract: IMPROVED SYNTHESIS OF PEPTIDES BY THE CARBODIIMIDE METHOD IN WHICH AN AMINO-PROTECTED AMINO ACID OR PEPTIDE HAVING A REACTIVE CARBOXY GROUP IS CONDENSED WITH A CARBOXY-PROTECTED AMINO ACID OR PEPTIDE HAVING A REACTIVE AMINO IN THE PRESENCE OF 3-HYDROXY-4-OXO3,4-DIHYDRO-1,2,3-BENZOTRIAZINE AS WELL AS IN THE PRESENCE OF A CARBODIIMIDE SUCH AS DICYCLOHEXYL CARBODIIMIDE.
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公开(公告)号：NZ222076A
公开(公告)日：1989-09-27
申请号：NZ22207687
申请日：1987-10-07
Applicant: HOECHST AG
Inventor： KONIG W , SANDOW J K , KOLAR C
IPC: A61K38/00 , A61K38/04 , A61P5/00 , A61P9/12 , C07K7/06 , C07K7/23 , C07K9/00 , C07K14/575 , C07K7/20 , A61K37/43
Abstract: The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1), beta -Asn, beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.
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公开(公告)号：SE414172B
公开(公告)日：1980-07-14
申请号：SE7411157
申请日：1974-09-04
Applicant: HOECHST AG
Inventor： KONIG W , ZWISLER O , GUTHORLEIN G
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Patent Agency Ranking
公开(公告)号：DK361375A
公开(公告)日：1976-02-10
申请号：DK361375
申请日：1975-08-08
Applicant: HOECHST AG
Inventor： KONIG W , GEIGER R , SANDOW J K
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公开(公告)号：SE430060B
公开(公告)日：1983-10-17
申请号：SE7704110
申请日：1977-04-07
Applicant: HOECHST AG
Inventor： KONIG W , GEIGER R , OBERMEIER R , TEETZ V
IPC: A61K38/22 , C07K14/575 , C07K1/14 , C07K14/645 , C07C103/52 , A61K37/24
Abstract: A process for the purification of secretin by chromatography on an alkylated dextran gel is disclosed, as is a method of its manufacture appropriate for preparing larger amounts of secretin.
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公开(公告)号：SE424184B
公开(公告)日：1982-07-05
申请号：SE7508926
申请日：1975-08-07
Applicant: HOECHST AG
Inventor： KONIG W , GEIGER R , SANDOW J K
IPC: A61K38/04 , A61K38/00 , A61P5/00 , C07K5/103 , C07K7/23 , C07K14/575 , C07C103/52
Abstract: The present invention relates to peptides having strong LH-RH/FSH-RH activity, wherein Gly in the 6-position is replaced by different substituted amino acids and in the 10-position there is glycinamide or glycine in the 10-position is replaced by a NH-alkyl group with 1-3 carbon atoms or a NH-cyclopropyl group. The invention relates as well to a process for manufacturing said peptides, and to pharmaceutical preparations containing said peptides.
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公开(公告)号：DK361875A
公开(公告)日：1976-02-10
申请号：DK361875
申请日：1975-08-08
Applicant: HOECHST AG
Inventor： KONIG W , GEIGER R , SANDOW J K
Abstract: The present invention relates to peptides having strong LH-RH/FSH-RH activity, wherein Gly in the 6-position is replaced by different substituted amino acids and in the 10-position there is glycinamide or glycine in the 10-position is replaced by a NH-alkyl group with 1-3 carbon atoms or a NH-cyclopropyl group. The invention relates as well to a process for manufacturing said peptides, and to pharmaceutical preparations containing said peptides.
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公开(公告)号：DK209575A
公开(公告)日：1975-11-15
申请号：DK209575
申请日：1975-05-13
Applicant: HOECHST AG
Inventor： KONIG W , GEIGER R , WISSMANN H , KRUSE H J , PETERFALVI M
IPC: A61K38/00 , C07C271/22 , C07D207/28 , C07K1/113 , C07K5/06 , C07K5/078 , C11D1/72 , C11D1/825 , C11D17/00 , C07D
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