公开(公告)号：ES2111092T3

公开(公告)日：1998-03-01

申请号：ES93108559

申请日：1993-05-27

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS DR ,  GLOMBIK HEINER DR ,  KRAMER WERNER DR DR ,  WESS GUNTHER DR

IPC: A61K31/575 ,  A61P1/00 ,  A61P3/00 ,  A61P3/06 ,  A61P7/00 ,  C07H9/00 ,  C07J9/00 ,  C07J41/00

Abstract: Bile acid derivatives of the formula I Z(X-GS)n in which GS, X, Z and n have the stated meanings, and a process for the production of these compounds are described. The compounds have pharmacological activity and can therefore be used as pharmaceuticals, in particular as hypolipidaemic.

公开(公告)号：DE19633268A1

公开(公告)日：1998-02-26

申请号：DE19633268

申请日：1996-08-19

Applicant: HOECHST AG

Inventor： SEGGERN HEINKE VON DR ,  KRAMER WERNER DR DR ,  WESS GUENTHER DR

IPC: A61K47/48 ,  A61K31/765 ,  A61K31/785 ,  A61P1/16 ,  A61P9/10 ,  C08F8/00 ,  C08F12/00 ,  C08F20/12 ,  C08F20/54 ,  C08F26/00 ,  C08F246/00 ,  C08F226/02 ,  A61K31/75

Abstract: Polymer bile acid resorption inhibitors with simultaneous bile acid adsorbing effect are disclosed, as well as a process for preparing the same, medicaments which contain these compounds and their use. Vinyl copolymers are disclosed which contain units of formula (I), in which R to R , d, e, f, H, L, A, Y, Z and B have the meanings indicated in the description. Also disclosed is a process for preparing the same. These compounds are suitable for treating lipid metabolism disturbances.

公开(公告)号：CZ281075B6

公开(公告)日：1996-06-12

申请号：CS369791

申请日：1991-12-05

Applicant: HOECHST AG

Inventor： KRAMER WERNER DR DR ,  WESS GUNTHER DR ,  MULLNER STEFAN DR ,  NEUBAUER HORST DR

IPC: A61K31/575 ,  A61K31/58 ,  A61P3/06 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00

Abstract: The invention relates to bile acid derivatives of the formula I G1-X-G2(I) in which G1 and G2 are bile acid radicals or modified bile acid radicals in the form of the free acids, the esters or amides, the salt forms and also the forms derivatized on the alcohol groups and X is a bridge group or a single covalent bond, it being possible for G1 and G2 to be optionally bonded via X. The compounds according to the invention have a high affinity for the specific bile acid transport system of the small intestine and inhibit bile acid absorption in a concentration-dependent and competitive manner.

公开(公告)号：AT135380T

公开(公告)日：1996-03-15

申请号：AT92121459

申请日：1992-12-17

Applicant: HOECHST AG

Inventor： KRAMER WERNER DR DR ,  MUELLNER STEFAN DR ,  GUTWEILER MATTHIAS DR ,  KROGGEL MATTHIAS DR

IPC: A23L1/30 ,  A23L29/275 ,  A61K31/375 ,  A61K31/78 ,  A61K31/785 ,  A61K47/32 ,  A61P1/16 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J41/00 ,  C07J43/00 ,  C08F12/00 ,  C08F12/02 ,  C08F12/26 ,  C08F16/14 ,  C08F16/16 ,  C08F16/26 ,  C08F16/36 ,  C08F16/38 ,  C08F18/02 ,  C08F20/26 ,  C08F20/52 ,  C08F20/54 ,  C08F20/58 ,  C08F22/40 ,  C08F26/02 ,  C08F26/10 ,  C08F220/28 ,  C08F226/10 ,  C11D1/02

公开(公告)号：CZ9401134A3

公开(公告)日：1994-12-15

申请号：CZ113494

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS DR ,  GLOMBIK HEINER DR ,  KRAMER WERNER DR DR ,  WESS GUNTHER DR

IPC: A61K31/575 ,  A61P3/06 ,  A61P9/00 ,  C07J3/00 ,  C07J7/00 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J51/00

CPC classification number: C07J3/005 ,  C07J3/00 ,  C07J7/0005 ,  C07J7/002 ,  C07J7/007 ,  C07J9/005 ,  C07J31/006 ,  C07J41/0005 ,  C07J41/0011 ,  C07J41/0027 ,  C07J41/0061 ,  C07J41/0066 ,  C07J41/0088 ,  C07J41/0094 ,  C07J51/00

公开(公告)号：CZ289515B6

公开(公告)日：2002-02-13

申请号：CZ113594

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS DR ,  GLOMBIK HEINER DR ,  KRAMER WERNER DR DR ,  WESS GUNTHER DR

IPC: A61K31/575 ,  A61K31/58 ,  A61K31/675 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J17/00 ,  C07J41/00 ,  C07J43/00

Abstract: In the present invention there are disclosed bile acid tetrazole derivatives of the general formula G1-X-G2, in which G1 represents a hydrogen atom or the group of the general formula II, G2 represents the group of the general formula IV and X represents a covalent bond or a bridge group. These derivatives exhibit high affinity to the transport system of bile acids in the small intestine and inhibit concentration-dependent and competitively dependent resorption of bile acids and they can be therefore used as medicaments.

公开(公告)号：DK0624594T3

公开(公告)日：1999-12-13

申请号：DK94106845

申请日：1994-05-02

Applicant: HOECHST AG

Inventor： GLOMBIK HEINER DR ,  ENHSEN ALFONS DR ,  KRAMER WERNER DR DR ,  WESS GUENTHER DR

IPC: A61K31/575 ,  A61K31/58 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00

Abstract: Monomeric bile acid derivatives of the formula I Z-X-GS I, in which GS, X and Z have the stated meanings, and processes for their preparation are described. The compounds have valuable pharmacological properties and can therefore be used as medicines.

公开(公告)号：DK0624596T3

公开(公告)日：1998-10-07

申请号：DK94106848

申请日：1994-05-02

Applicant: HOECHST AG

Inventor： GLOMBIK HEINER DR ,  ENHSEN ALFONS DR ,  KRAMER WERNER DR DR ,  WESS GUENTER DR

IPC: A61K31/575 ,  A61K31/58 ,  A61K31/675 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J17/00 ,  C07J41/00 ,  C07J43/00

Abstract: Tetrazole bile acid derivatives of the formula I G1 - X - G2 I in which G1, G2 and X have the stated meanings, and processes for their preparation are described. The compounds have valuable pharmacological properties and can therefore be used as medicines.

公开(公告)号：AT169633T

公开(公告)日：1998-08-15

申请号：AT94106846

申请日：1994-05-02

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS DR ,  GLOMBIK HEINER DR ,  KRAMER WERNER DR DR ,  WESS GUENTHER DR

IPC: A61K31/575 ,  A61P3/06 ,  A61P9/00 ,  C07J3/00 ,  C07J7/00 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J51/00

Abstract: nor-Bile acid derivatives of the formula I G1 - X - G2 I, in which G1, G2 and X have the stated meanings, processes for preparing these compounds and medicines are described. On the basis of their pharmacological action, they can be used as antihyperlipidaemic.

公开(公告)号：GR3026496T3

公开(公告)日：1998-07-31

申请号：GR980400679

申请日：1998-04-03

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS DR ,  GLOMBIK HEINER DR ,  KRAMER WERNER DR DR ,  WESS GUENTER DR

IPC: A61K31/575 ,  A61K31/58 ,  A61K31/675 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J17/00 ,  C07J41/00 ,  C07J43/00

Abstract: Tetrazole bile acid derivatives of the formula I G1 - X - G2 I in which G1, G2 and X have the stated meanings, and processes for their preparation are described. The compounds have valuable pharmacological properties and can therefore be used as medicines.