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1.发明授权N{11 {11 {11 {11 {11 {11 , n{11 {11 {11 {11 {11 {11 -di-tert. butyloxycarbonyl-insulin and process for its manufacture 失效N {11 {11 {11 {11 {11 {11} 丁二烯 - 胰蛋白酶及其制备方法
公开(公告)号：US3684791A
公开(公告)日：1972-08-15
申请号：US3684791D
申请日：1969-09-22
Applicant: HOECHST AG
Inventor： GEIGER ROLF , PFAFF WERNER , BANDER ALFRED , SCHONE HANS-HERMANN , MAGER ADOLF
IPC: A61K38/00 , C07K14/62 , A61K17/02 , C07C103/52
Abstract: N (A1), N (B29)-di-tert. butyloxycarbonyl insulin, useful as a hypoglycemic agent. A method for its preparation by reacting insulin, in a mixture of an N,N''-dialkylcarboxylic acid amide having a total of from three to six carbon atoms and an aqueous buffer solution having a pH between 8.0 and 9.0, with a 20 to 75 fold molar excess of tert. butyloxycarbonyl azide at 20* to 50*C.
Abstract translation: N（A1），N（B29） - 二叔丁基。 丁氧羰基胰岛素，可用作降血糖药。 其制备方法是使胰岛素在总共3至6个碳原子的N，N'-二烷基羧酸酰胺与pH为8.0-9.0的水溶液的混合物中反应20至75 倍摩尔过量的叔。 丁氧基羰基叠氮化物在20〜50℃
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公开(公告)号：AU8007375A
公开(公告)日：1976-10-14
申请号：AU8007375
申请日：1975-04-11
Applicant: HOECHST AG
Inventor： MAGER ADOLF , SCHONE HANS-HERMANN , GEIGER ROLF , BURGERMEISTER WOLFGANG
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3.发明专利
公开(公告)号：CA1047919A
公开(公告)日：1979-02-06
申请号：CA224590
申请日：1975-04-11
Applicant: HOECHST AG
Inventor： MAGER ADOLF , SCHONE HANS-HERMANN , GEIGER ROLF , BURGERMEISTER WOLFGANG
Abstract: NEW PHARMACEUTICAL INSULIN PREPARATIONS HAVING ANTIDIABETIC ACTIVITY AND PROCESS FOR THEIR MANUFACTURE of the disclosure: An insulin preparation in an aqueous suspension which comprises a crystallized insulin, dissolved des-phenyl-alanineB1-insulin of the same species and 25 to 80 mcg of zinc ions per 100 I.U. of insuline and a process for its manufacture.
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公开(公告)号：HU174160B
公开(公告)日：1979-11-28
申请号：HUHO001790
申请日：1975-04-11
Applicant: HOECHST AG
Inventor： MAGER ADOLF , SCHOENE HANS-HERMANN , GEIGER ROLF , BUERGERMEISTER WOLFGANG
IPC: A61K37/26
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公开(公告)号：NO137845B
公开(公告)日：1978-01-30
申请号：NO439873
申请日：1973-11-15
Applicant: HOECHST AG
Inventor： MAGER ADOLF , SCHOENE HANS-HERMANN , GEIGER ROLF , ENZMANN FRANZ
Abstract: 1450598 Insulin preparations HOECHST AG 14 Nov 1973 [16 Nov 1972] 52889/73 Heading A5B Insulin preparations useful as depot insulin for the treatment of diabetes mellitus comprise, in an aqueous suspension, a crystallised complete insulin and amorphous desphenyl-alanine B1 insulin of the same species. The two insulin components are porcine or bovine and the preparation preferably has a pH of 6.8 to 7.6. The preparations may also contain zinc ions (e.g. from zinc chloride), sodium acetate, sodium chloride, and/or a preservative such as 4-hydroxybenzoic acid methyl ester. The preparations are administered parenterally and may be in dosage unit form e.g. an ampoule or in a two-coponent pack.
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Patent Agency Ranking
公开(公告)号：NO137845C
公开(公告)日：1978-05-10
申请号：NO439873
申请日：1973-11-15
Applicant: HOECHST AG
Inventor： MAGER ADOLF , SCHOENE HANS-HERMANN , GEIGER ROLF , ENZMANN FRANZ
Abstract: 1450598 Insulin preparations HOECHST AG 14 Nov 1973 [16 Nov 1972] 52889/73 Heading A5B Insulin preparations useful as depot insulin for the treatment of diabetes mellitus comprise, in an aqueous suspension, a crystallised complete insulin and amorphous desphenyl-alanine B1 insulin of the same species. The two insulin components are porcine or bovine and the preparation preferably has a pH of 6.8 to 7.6. The preparations may also contain zinc ions (e.g. from zinc chloride), sodium acetate, sodium chloride, and/or a preservative such as 4-hydroxybenzoic acid methyl ester. The preparations are administered parenterally and may be in dosage unit form e.g. an ampoule or in a two-coponent pack.
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公开(公告)号：AU6250573A
公开(公告)日：1975-05-15
申请号：AU6250573
申请日：1973-11-15
Applicant: HOECHST AG
Inventor： MAGER ADOLF , ENZMANN FRANZ , SCHONE HANS-HERMANN , GEIGER ROLF
Abstract: 1450598 Insulin preparations HOECHST AG 14 Nov 1973 [16 Nov 1972] 52889/73 Heading A5B Insulin preparations useful as depot insulin for the treatment of diabetes mellitus comprise, in an aqueous suspension, a crystallised complete insulin and amorphous desphenyl-alanine B1 insulin of the same species. The two insulin components are porcine or bovine and the preparation preferably has a pH of 6.8 to 7.6. The preparations may also contain zinc ions (e.g. from zinc chloride), sodium acetate, sodium chloride, and/or a preservative such as 4-hydroxybenzoic acid methyl ester. The preparations are administered parenterally and may be in dosage unit form e.g. an ampoule or in a two-coponent pack.
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公开(公告)号：CA998338A
公开(公告)日：1976-10-12
申请号：CA185704
申请日：1973-11-13
Applicant: HOECHST AG
Inventor： MAGER ADOLF , SCHONE HANS-HERMANN , GEIGER ROLF , ENZMANN FRANZ
IPC: C07K14/575 , A61K9/107 , A61K38/28 , C07K14/62 , C07K16/00
Abstract: 1450598 Insulin preparations HOECHST AG 14 Nov 1973 [16 Nov 1972] 52889/73 Heading A5B Insulin preparations useful as depot insulin for the treatment of diabetes mellitus comprise, in an aqueous suspension, a crystallised complete insulin and amorphous desphenyl-alanine B1 insulin of the same species. The two insulin components are porcine or bovine and the preparation preferably has a pH of 6.8 to 7.6. The preparations may also contain zinc ions (e.g. from zinc chloride), sodium acetate, sodium chloride, and/or a preservative such as 4-hydroxybenzoic acid methyl ester. The preparations are administered parenterally and may be in dosage unit form e.g. an ampoule or in a two-coponent pack.
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公开(公告)号：FI751084A
公开(公告)日：1975-10-14
申请号：FI751084
申请日：1975-04-10
Applicant: HOECHST AG
Inventor： MAGER ADOLF , SCHOENE HANS-HERMANN , GEIGER ROLF , BURGERMEISTER WOLFGANG
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10.发明专利
公开(公告)号：CA908160A
公开(公告)日：1972-08-22
申请号：CA908160D
Applicant: HOECHST AG
Inventor： GEIGER ROLF , PFAFF WERNER , BANDER ALFRED , MAGER ADOLF , SCHONE HANS-HERMANN
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