公开(公告)号：HU224211B1

公开(公告)日：2005-06-28

申请号：HU9503932

申请日：1995-12-29

Applicant: HOECHST AG

Inventor： CRAUSE PETER DR ,  KAISER JOACHIM DR ,  ENGLERT HEINRICH DR ,  GOEGELEIN HEINZ DR ,  MANRIA DIETER DR ,  GERLACH UWE DR

IPC: C07D333/20 ,  A61K31/18 ,  A61K31/34 ,  A61K31/35 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/40 ,  A61K31/425 ,  A61K31/426 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/40 ,  C07C335/42 ,  C07D207/32 ,  C07D207/335 ,  C07D213/40 ,  C07D277/28 ,  C07D307/52 ,  C07C311/51

Abstract: Substd. benzenesulphonylurea or -thiourea cpds. of formula (I) are new: R1 = H, 1-6C alkyl, or 3-6C cycloalkyl; R2 = 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl, or a 1-8C chain in which 1-3C may be replaced by O, NH or S; R3, R4 = H or 1-6C alkyl; or R3 + R4 = (CH2)p; p = 2-5; E, X = O or S; Y = ÄC(R5)2Üm; R5 = H, Me or Et; m = 1 or 2; Ar = phenyl, thienyl, furyl, pyrrolyl, thiazolyl, naphthyl or pyridyl (all opt. substd. by 1-3 Me, Et, MeO, EtO, Cl, Br or F).

公开(公告)号：HU227308B1

公开(公告)日：2011-03-28

申请号：HU9503931

申请日：1995-12-29

Applicant: HOECHST AG

Inventor： KAISER JOACHIM DR ,  ENGLERT HEINRICH DR ,  GOEGELEIN HEINZ DR ,  MANRIA DIETER DR ,  GERLACH UWE DR

IPC: C07C311/51 ,  C07D331/02 ,  A61K31/18 ,  A61K31/38 ,  A61K31/64 ,  A61P9/00 ,  A61P9/02 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/46 ,  C07C335/42 ,  C07D203/08 ,  C07D295/00 ,  C07D303/48

Abstract: N-(3-substd. benzensulphonyl)-urea or -thiourea derivs. of formula (I) and their salts are new. R1 = H, 1-7C alkyl or 3-7C cycloalkyl; R2 = H, F, Cl, 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl or CbH2b+1, in which one or more C can be replaced by Het; Het = heteroatoms, e.g. O, NH or S; b = 1-8; 1-8C alkyl in which 1-4C may be replaced by O, N or S; R3 = H, 1-12C alkyl, 3-10C cycloalkyl, 1-6C fluoroalkyl, 3-6C fluorocycloalkyl or CaH2a+1 in which 1-4C are replaced by Het; a = 1-10; R4 = aryl or as R3; or R3+R4 = CbH2b, in which one or more CH2 can be replaced by Het; R5 = as R4; R6 = as R4 but not 3-10C cycloalkyl; Q, X = O or S; Y = -(C(R7)2)c, O, S or NH; c = 1-4; R7 = H, 1-4C alkyl, F, Cl or Br.

公开(公告)号：HU226463B1

公开(公告)日：2008-12-29

申请号：HU9503879

申请日：1995-12-28

Applicant: HOECHST AG

Inventor： KAISER JOACHIM DR ,  ENGLERT HEINRICH DR ,  GOEGELEIN HEINZ DR ,  MANRIA DIETER DR ,  GERLACH UWE DR

IPC: A61K31/18 ,  C07C311/51 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/42

Abstract: Substd. benzene sulphonyl urea and thiourea derivs. of formula (I) and their salts are new. R1 = H, Me or CF3; R2 = 4-10C alkoxy with 1-6C replaced by O, S or NH; Q = O or S; Y = ÄC(R3)2Üm; R3 = H, Me or Et; R' = H, halo or 1-6C alkyl; R" = halo, 1-4C alkoxy or 1-4C alkyl; and m = 1-4.

公开(公告)号：HU226462B1

公开(公告)日：2008-12-29

申请号：HU9503877

申请日：1995-12-28

Applicant: HOECHST AG

Inventor： KAISER JOACHIM DR ,  ENGLERT HEINRICH DR ,  GOEGELEIN HEINZ DR ,  MANRIA DIETER DR ,  GERLACH UWE DR

IPC: A61K31/18 ,  C07C311/51 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/36 ,  C07C303/40 ,  C07C311/57 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/00 ,  C07C335/42

Abstract: Substd. benzene sulphonyl urea and thiourea cpds. of formula (I) and their salts are new. R1 = H, 1-7C alkyl or 3-7C cycloalkyl; R2 = H, 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl, or 1-8C chain (in which 1-4C atoms are replaced by Het), F or Cl; R3, R4 = H, 1-12C alkyl, 3-10C cycloalkyl, 1-6C fluoroalkyl, 3-6C fluorocycloalkyl, or 1-10C chain in which 1-4C atoms are replaced by Het; or R3+R4 = (CH2)p, opt. with 1 or more CH2 replaced by heteroatoms; p = 2-8; Q, X = O or S; Y = (CR5R6)m; R5; R6 = H, Me or Et (opt. different in different CR5R6 gps.); Het = heteroatom such as O, N or S, m = 1-4.

公开(公告)号：HU226121B1

公开(公告)日：2008-04-28

申请号：HU9600218

申请日：1996-01-31

Applicant: HOECHST AG

Inventor： CRAUSE PETER DR ,  ENGLERT HEINRICH DR ,  GOEGELEIN HEINZ DR ,  HARTUNG JENS DR ,  KAISER JOACHIM DR ,  MANRIA DIETER DR

IPC: C07D333/34 ,  A61K31/38 ,  A61K31/381 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  A61P43/00 ,  C07C335/00

Abstract: N-((2-Benzamidoethyl)- thiophene-sulphonyl)-urea or-thiourea derivs. of formula (I) are new. R1 = H, halogen, Me, Et, OMe, OEt, SMe, SEt, 1-2C fluoroalkyl or 1-2C fluoroalkoxy; X = O or S; R2 = H, Me or CF3; Y, Z = H, F, Cl, Br, I, Me, Et, OMe or OEt.