公开(公告)号：NZ217994A

公开(公告)日：1988-09-29

申请号：NZ21799486

申请日：1986-10-20

Applicant: HOECHST AG

Inventor： ENGELS J ,  UHLMANN E ,  WENGENMAYER F ,  MULLNER H ,  LEINEWEBER M ,  WINNACKER E-L ,  MERTZ R

IPC: C12N15/09 ,  A61K38/00 ,  C07K14/00 ,  C07K14/52 ,  C07K14/54 ,  C07K14/55 ,  C12P21/02 ,  C07K15/08 ,  C12N15/00 ,  C12N1/20 ,  C12P21/00

Abstract: Proteins whose amino-acid sequence essentially corresponds to that of natural interleukin-2 (IL-2) but which lacks the first 7 N-terminal amino acids display the biological activity of IL-2. These proteins can be prepared by genetic manipulation. They are suitable for the preparation of pharmaceuticals with IL-2 activity.