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    2.
    发明专利
    未知

    公开(公告)号：DE59509904D1

    公开(公告)日：2002-01-17

    申请号：DE59509904

    申请日：1995-09-28

    Applicant: HOECHST AG

    Inventor： NAUMANN CHRISTOPH ,  YOSHIKAWA KATSUHIRO ,  KITAMURA KAZUYUKI ,  INAZU MIZUHO

    IPC: A61K31/66 ,  A61P3/00 ,  A61P19/10 ,  A61P43/00 ,  C07F9/22 ,  C07F9/24 ,  C07F9/58 ,  C07F9/6533

    Abstract: Imidobisphosphoric acid cpds. of formula (I) and their salts are new: R1 = 1-10C alkyl, 1-8C alkanoyl, 6-10C aryl or Het (all opt. substd. by 1-6 halo, OH, NH2, NHCOR7, OCOR7, N(R8)2) or XA; X = a bond or 1-10C alkyl; A = 3-10C cycloalkyl (opt. substd. by ≤ 3 R6 gps.); R6 = 1-6C alkyl (opt. substd. by 1-6 halo or NHCOR7); R7 = 1-6C alkyl; R8 = H or 1-3C alkyl; R2-R5 = H, 1-5C alkyl, Li, Na, K or Si(R) (sic); R = 1-5C alkyl; with the following cpds. excluded: (a) R1 = Me and R2-R5 = Me, Et, Pr, i-Pr, Bu or i-Bu; (b) R1 = Me or Et, R2, R3 =Et and R4, R5=Me; (c) R1 = Et and R2-R5=Et, Pr, i-Pr, Bu or i-Bu; (d) R1 = i-Pr, R2, R3 = i-Pr and R4, R5 = Me; (e) R1 = Bu and R2-R5 = Et, i-Pr or Bu; (f) R1 = i-Bu or 1-tert. butyl-1,1'-dimethyl propyl and R2-R5=Et; (g) R1 = pentyl and R2-R5 = Et, Pr or Bu; (h) R1 = dodecyl and R2-R = Bu; Het = opt. partly or completely unsatd. 5 or 6 membered monocyclic or 8-10 membered bicyclic ring contg. 1-3 heteroatoms (N, O or S), pref. piperidinyl, pyrrolidinyl, piperazinyl, pyridinyl, morpholinyl, imidazolyl or pyrazolyl.

    3.
    发明专利
    未知

    公开(公告)号：AT210137T

    公开(公告)日：2001-12-15

    申请号：AT95115276

    申请日：1995-09-28

    Applicant: HOECHST AG

    Inventor： NAUMANN CHRISTOPH ,  YOSHIKAWA KATSUHIRO ,  KITAMURA KAZUYUKI ,  INAZU MIZUHO

    IPC: A61K31/66 ,  A61P3/00 ,  A61P19/10 ,  A61P43/00 ,  C07F9/22 ,  C07F9/24 ,  C07F9/58 ,  C07F9/6533

    Abstract: Imidobisphosphoric acid cpds. of formula (I) and their salts are new: R1 = 1-10C alkyl, 1-8C alkanoyl, 6-10C aryl or Het (all opt. substd. by 1-6 halo, OH, NH2, NHCOR7, OCOR7, N(R8)2) or XA; X = a bond or 1-10C alkyl; A = 3-10C cycloalkyl (opt. substd. by ≤ 3 R6 gps.); R6 = 1-6C alkyl (opt. substd. by 1-6 halo or NHCOR7); R7 = 1-6C alkyl; R8 = H or 1-3C alkyl; R2-R5 = H, 1-5C alkyl, Li, Na, K or Si(R) (sic); R = 1-5C alkyl; with the following cpds. excluded: (a) R1 = Me and R2-R5 = Me, Et, Pr, i-Pr, Bu or i-Bu; (b) R1 = Me or Et, R2, R3 =Et and R4, R5=Me; (c) R1 = Et and R2-R5=Et, Pr, i-Pr, Bu or i-Bu; (d) R1 = i-Pr, R2, R3 = i-Pr and R4, R5 = Me; (e) R1 = Bu and R2-R5 = Et, i-Pr or Bu; (f) R1 = i-Bu or 1-tert. butyl-1,1'-dimethyl propyl and R2-R5=Et; (g) R1 = pentyl and R2-R5 = Et, Pr or Bu; (h) R1 = dodecyl and R2-R = Bu; Het = opt. partly or completely unsatd. 5 or 6 membered monocyclic or 8-10 membered bicyclic ring contg. 1-3 heteroatoms (N, O or S), pref. piperidinyl, pyrrolidinyl, piperazinyl, pyridinyl, morpholinyl, imidazolyl or pyrazolyl.

    IMIDOBISPHOSPHORIC ACIDS, PROCESS FOR PRODUCING THEM, AND USE OF THEM
    5.
    发明专利
    IMIDOBISPHOSPHORIC ACIDS, PROCESS FOR PRODUCING THEM, AND USE OF THEM 未知

    公开(公告)号：HU9502901D0

    公开(公告)日：1995-11-28

    申请号：HU9502901

    申请日：1995-10-04

    Applicant: HOECHST AG

    Inventor： KITAMURA KAZUYUKI ,  NAUMANN CHRISTOPH ,  YOSHIKAWA KATSUHIRO ,  INAZU MIZUHO

    IPC: A61K31/66 ,  A61P3/00 ,  A61P19/10 ,  A61P43/00 ,  C07F9/22 ,  C07F9/24 ,  C07F9/58 ,  C07F9/6533

    Abstract: Imidobisphosphoric acid cpds. of formula (I) and their salts are new: R1 = 1-10C alkyl, 1-8C alkanoyl, 6-10C aryl or Het (all opt. substd. by 1-6 halo, OH, NH2, NHCOR7, OCOR7, N(R8)2) or XA; X = a bond or 1-10C alkyl; A = 3-10C cycloalkyl (opt. substd. by ≤ 3 R6 gps.); R6 = 1-6C alkyl (opt. substd. by 1-6 halo or NHCOR7); R7 = 1-6C alkyl; R8 = H or 1-3C alkyl; R2-R5 = H, 1-5C alkyl, Li, Na, K or Si(R) (sic); R = 1-5C alkyl; with the following cpds. excluded: (a) R1 = Me and R2-R5 = Me, Et, Pr, i-Pr, Bu or i-Bu; (b) R1 = Me or Et, R2, R3 =Et and R4, R5=Me; (c) R1 = Et and R2-R5=Et, Pr, i-Pr, Bu or i-Bu; (d) R1 = i-Pr, R2, R3 = i-Pr and R4, R5 = Me; (e) R1 = Bu and R2-R5 = Et, i-Pr or Bu; (f) R1 = i-Bu or 1-tert. butyl-1,1'-dimethyl propyl and R2-R5=Et; (g) R1 = pentyl and R2-R5 = Et, Pr or Bu; (h) R1 = dodecyl and R2-R = Bu; Het = opt. partly or completely unsatd. 5 or 6 membered monocyclic or 8-10 membered bicyclic ring contg. 1-3 heteroatoms (N, O or S), pref. piperidinyl, pyrrolidinyl, piperazinyl, pyridinyl, morpholinyl, imidazolyl or pyrazolyl.

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