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    2.
    发明专利
    未知

    公开(公告)号：DE1210514B

    公开(公告)日：1966-02-10

    申请号：DEF0041297

    申请日：1963-11-16

    Applicant: HOECHST AG

    Inventor： OEPPINGER DR HEINZ ,  KOERNLEIN DR MAX ,  NESEMANN DR GEORG ,  OPPERMANN DR ADOLF

    IPC: C07G11/00 ,  C12P1/06

    Abstract: An increased yield of the antibiotic moenomycin is achieved in its manufacture by microbiological fermentation (see Specification 977,327) of a moenomycin-producing strain of Streptomyces bambergiensis ATCC No. 13879, Streptomyces ghanaensis ATCC No. 14672, Streptomyces enderensis nov. spec. 2861 or Streptomyces geyiriensis nov. spec. 3888, wherein animal and/or vegetable fats are used as sources of carbon. Animal fat, e.g. lard or knackerey fat, may be used in a concentration from 0.1 to 10% by weight. As vegetable fats, oils, e.g. soya-bean oil, may be used. The fats may be used as the sole carbon source or together with other carbon sources, e.g. sugars.

    4.
    发明专利
    未知

    公开(公告)号：DE1207046B

    公开(公告)日：1965-12-16

    申请号：DEF0040226

    申请日：1963-07-13

    Applicant: HOECHST AG

    Inventor： NAHM DR HELMUT ,  OPPERMANN DR ADOLF ,  HOFFMANN DR HINRICH ,  KOERNLEIN DR MAX ,  OEPPINGER DR HEINZ

    IPC: C07D499/00 ,  C07D499/60

    Abstract: Penicillin derivatives of the formula wherein R1 represents a straight or branched chain alkyl, cycloalkyl, aralkyl, hydroxyalkyl, epoxyalkyl, alkylaminoalkyl, dialkylaminoalkyl, a group of the formula XN-A-in which A represents an alkylene group and X represents an alkylene or oxygen-interrupted alkylene group of at least two carbon atoms, phenyl, nitrophenyl, dinitrophenyl, halogenonitrophenyl, alkenylalkyl, aralkenylalkyl, alkylnitrophenyl or halogenoalkyl-nitrophenyl; R2 represents an alkyl group containing 1 to 4 carbon atoms, hydrogen or a halogen; R3 represents hydrogen, an alkyl group containing 1 to 4 carbon atoms, a hydroxy or alkoxy group or a halogen and R4 represents hydrogen, or a straight or branched chain alkyl group containing 1 to 4 carbon atoms or a benzyloxymethyl, alkoxyalkyl, phenyl or halogenophenyl are prepared by reacting 6-amino-penicillanic acid in the presence of a proton acceptor with a derivative (e.g. the halide, anhydride, azide or an activated ester) of an a -phenoxy fatty acid of the formula wherein R1, R2, R3 and R4 have the meaning given above. Certain compounds disclosed in Specification 1,077,465 are disclaimed. The reaction may be performed at pH 6-9 with the use of buffer solutions (e.g. sodium bicarbonate or di-sodium phosphate) and at 0-30 DEG C. The compounds are generally isolated as salts with alkali metal, alkaline earth metal or ammonium compounds or organic bases or salts thereof which are added to the reaction mixture as solutions or suspensions and the salt is isolated by precipitation or lyophilization. The Specification contains many examples of penicillin derivatives having the above formula. Pharmaceutical compositions comprise the above penicillin derivatives or salts thereof in admixture or conjunction with a physiologically tolerable carrier.

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