公开(公告)号：KR840000410B1

公开(公告)日：1984-04-02

申请号：KR800001072

申请日：1980-03-14

Applicant: HOECHST AG

Inventor： HILLER DIETRICH ,  KLATT PETER ,  REUL BERNHARD

IPC: A61D7/00 ,  A61M37/00

公开(公告)号：US3883648A

公开(公告)日：1975-05-13

申请号：US41031173

申请日：1973-10-29

Applicant: HOECHST AG

Inventor： ROSS GERHARD ,  REUL BERNHARD

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/48 ,  A61K31/18 ,  A61K31/64 ,  A61K27/12

CPC classification number: A61K31/64 ,  A61K9/146 ,  A61K9/1611 ,  A61K9/1641 ,  A61K9/485 ,  A61K9/4866 ,  A61K31/18

Abstract: A method of making stable granules of N-4-(2-(5-chloro-2methoxybenzamido)-ethyl)-phenylsulfonyl-N''-cyclohexyl urea and salts thereof by dissolving or dispersing said materials in a melt of a water-soluble carrier material in the presence of an alkali metal carbonate or bicarbonate stabilizing the compound against the temperatures of the melt, and then solidifying the molten mass into droplet granules. Stable granules prepared according to this method and dosage unit forms comprising said granules.

Abstract translation: 一种制备N-4- [2-（5-氯-2-甲氧基苯甲酰氨基） - 乙基] - 苯基磺酰基-N'-环己基脲及其盐的稳定颗粒的方法，其通过将所述材料溶解或分散在水 - 在碱金属碳酸盐或碳酸氢盐存在下，使化合物抵抗熔体的温度稳定化，然后将熔融体固化成液滴颗粒。 根据该方法制备的稳定颗粒和包含所述颗粒的剂量单位形式。

公开(公告)号：US3642393A

公开(公告)日：1972-02-15

申请号：US3642393D

申请日：1970-04-09

Applicant: HOECHST AG

Inventor： ROSS GERHARD ,  REUL BERNHARD ,  TILLMANN WALTER ,  LIEBENHOFF REINHARDT

IPC: B01J2/02 ,  B29C23/00

CPC classification number: B01J2/02

Abstract: An apparatus has been provided for the manufacture of beadshaped granules from melts. It comprises a melt-containing vessel with a distributing bottom and a heating chamber for heating the distributing bottom, wherein the outlet apertures of the heating chamber have the shape of annular gaps which are formed by borings in the external wall of the heating chamber and by small tubes inserted into the distributing bottom and protruding through the bottom of the heating chamber.

Abstract translation: 已经提供了用于从熔体制造珠状颗粒的装置。 它包括具有分布底部的熔体容器和用于加热分布底部的加热室，其中加热室的出口孔具有由加热室的外壁中的钻孔形成的环形间隙的形状， 小管插入分配底部并突出通过加热室的底部。

公开(公告)号：CA2128034A1

公开(公告)日：1995-01-16

申请号：CA2128034

申请日：1994-07-14

Applicant: HOECHST AG

Inventor： REUL BERNHARD ,  PETRI WALTER

IPC: A61K9/107 ,  A61K9/00 ,  A61K9/12 ,  A61K9/14 ,  A61K9/50 ,  A61K9/72 ,  A61K47/24 ,  A61K31/34 ,  A61K31/44

Abstract: Drug formulations comprising coated, very sparingly water-soluble drugs for inhalational pharmaceutical forms, and process for their preparation Drug formulations comprising micronized particles of very sparingly water-soluble drugs which are coated with a natural, physiologically acceptable ampholytic surfactant soluble in water to give a micellar/colloidal solution, and a process for the preparation of these drug formulations, are described. When placed in an appropriate final container and after the addition of a chlorine-free, partially fluorinated propellant gas liquefiable under pressure, these formulations are suitable for inhalation.

公开(公告)号：GR3002215T3

公开(公告)日：1992-12-30

申请号：GR910400799

申请日：1991-06-28

Applicant: HOECHST AG

Inventor： REUL BERNHARD ,  PETRI WALTER DR

IPC: A23L1/304 ,  A61K8/30 ,  A61K8/37 ,  A61K47/00 ,  A61K47/12 ,  C07C51/00 ,  C07C51/41 ,  C07C59/08 ,  C07C67/00

Abstract: The calcium lactate-glycerol adduct, a molecular compound of 1 mol of calcium lactate and 2 mol of glycerol, and a process for its preparation are described. The adduct can be used as a calcium donor or auxiliary in pharmacy, cosmetics and food production.

公开(公告)号：PT87338B

公开(公告)日：1992-08-31

申请号：PT8733888

申请日：1988-04-27

Applicant: HOECHST AG

Inventor： PETRI WALTER ,  REUL BERNHARD

IPC: A61K6/00 ,  A61K9/00 ,  A61K9/06 ,  A61K47/36 ,  A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  A61K47/00

Abstract: A carrier for mucosa and denture adhesion pastes, pastes based on this carrier and a process for its preparation are described.

公开(公告)号：ES2022501B3

公开(公告)日：1991-12-01

申请号：ES88104745

申请日：1988-03-24

Applicant: HOECHST AG

Inventor： REUL BERNHARD ,  PETRI WALTER

IPC: A23L1/304 ,  A61K8/30 ,  A61K8/37 ,  A61K47/00 ,  A61K47/12 ,  C07C51/00 ,  C07C51/41 ,  C07C59/08 ,  C07C67/00

公开(公告)号：DE3862994D1

公开(公告)日：1991-07-04

申请号：DE3862994

申请日：1988-03-24

Applicant: HOECHST AG

Inventor： REUL BERNHARD ,  PETRI WALTER DR

IPC: A23L1/304 ,  A61K8/30 ,  A61K8/37 ,  A61K47/00 ,  A61K47/12 ,  C07C51/00 ,  C07C51/41 ,  C07C59/08 ,  C07C67/00

Abstract: The calcium lactate-glycerol adduct, a molecular compound of 1 mol of calcium lactate and 2 mol of glycerol, and a process for its preparation are described. The adduct can be used as a calcium donor or auxiliary in pharmacy, cosmetics and food production.

公开(公告)号：AT63898T

公开(公告)日：1991-06-15

申请号：AT88104745

申请日：1988-03-24

Applicant: HOECHST AG

Inventor： REUL BERNHARD ,  PETRI WALTER DR

IPC: A23L1/304 ,  A61K8/30 ,  A61K8/37 ,  A61K47/00 ,  A61K47/12 ,  C07C51/00 ,  C07C51/41 ,  C07C59/08 ,  C07C67/00

公开(公告)号：DK165988D0

公开(公告)日：1988-03-25

申请号：DK165988

申请日：1988-03-25

Applicant: HOECHST AG

Inventor： REUL BERNHARD ,  PETRI WALTER

IPC: A23L1/304 ,  A61K8/30 ,  A61K8/37 ,  A61K47/00 ,  A61K47/12 ,  C07C51/00 ,  C07C51/41 ,  C07C59/08 ,  C07C67/00

Abstract: The calcium lactate-glycerol adduct, a molecular compound of 1 mol of calcium lactate and 2 mol of glycerol, and a process for its preparation are described. The adduct can be used as a calcium donor or auxiliary in pharmacy, cosmetics and food production.