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公开(公告)号:DE3631829A1
公开(公告)日:1988-07-28
申请号:DE3631829
申请日:1986-09-19
Applicant: HOECHST AG
Inventor: MARQUARDT RUEDIGER DR , THEN JOHANN DR , DEGER HANS-MATTHIAS DR , WOEHNER GERHARD DR , ROBINSON MARTYN DR , DOHERTY ANDREW DR
IPC: C12N15/09 , C12N1/20 , C12N1/21 , C12N9/10 , C12N15/54 , C12P13/22 , C12R1/19 , C12N15/00 , C12P19/34
Abstract: Isolation of the tyrB gene present in E. coli ATCC 11303 and cloning thereof in a multicopy plasmid results, after the transformation of the initial strain with this plasmid, in a 10-fold increase in the yield of L-phenylalanine.
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公开(公告)号:DE3786728D1
公开(公告)日:1993-09-02
申请号:DE3786728
申请日:1987-09-10
Applicant: HOECHST AG
Inventor: MARQUARDT RUEDIGER DR , THEN JOHANN DR , DEGER HANS-MATTHIAS DR , WOEHNER GERHARD DR , ROBINSON MARTYN DR , DOHERTY ANDREW DR
Abstract: A replicating extra-chromosomal element contg. the isolated tyrB gene from E.coli ATCC 11303 is new. Also new are (1) E.coli ATCC 11303 (or its variants or mutants) transformed with these elements and (2) the tyrB gene. Pref. the element is a multicopy plasmid, specifically pAT153.
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公开(公告)号:AT92104T
公开(公告)日:1993-08-15
申请号:AT87113221
申请日:1987-09-10
Applicant: HOECHST AG
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公开(公告)号:DE3636722A1
公开(公告)日:1988-05-05
申请号:DE3636722
申请日:1986-10-29
Applicant: HOECHST AG
Inventor: MARQUARDT RUEDIGER DR , THEN JOHANN DR , DEGER HANS-MATTHIAS DR , WOEHNER GERHARD DR , ROBINSON MARTYN DR , DOHERTY ANDREW DR
IPC: C12N15/09 , C12N1/20 , C12N1/21 , C12N9/10 , C12P13/06 , C12P13/08 , C12R1/19 , C12N15/00 , C12P13/04
Abstract: The ilvE gene from the strain E. coli ATCC 11303 is suitable for achieving overproduction of the coded aliphatic transaminase and thus for preparing the branched-chain amino acids leucine, isoleucine and valine from the corresponding keto precursors.
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