公开(公告)号：HU9502722D0

公开(公告)日：1995-11-28

申请号：HU9502722

申请日：1995-09-18

Applicant: HOECHST AG

Inventor： WOLF ERHARD ,  ROSSMANITH ERHARD ,  THORWART WERNER ,  RAISS RUTH ,  WEITHMANN KLAUS ULRICH

IPC: A61K31/66 ,  A61K31/665 ,  A61K31/675 ,  A61P29/00 ,  A61P43/00 ,  C07F9/30 ,  C07F9/32 ,  C07F9/38 ,  C07F9/40 ,  C07F9/48 ,  C07F9/58 ,  C07F9/59 ,  C07F9/6509 ,  C07F9/6512 ,  C07F9/6533 ,  C07F9/655

Abstract: Medicaments contg. alpha-amino-3,5-di-t-butyl-4-hydroxybenzyl- phosphorus cpds. of formula (I) or their salts or stereoisomers are new: R1, R2 = H, 1-12C alkyl*, 1-12C alkyl (substd. by one or more of (a) phenyl*; (b) phenyl substd. by 1-3 halo, 1-3C alkyl, 1-3C alkoxy, methylenedioxy, NO2, NH2, amidino, guanidino, OH, 2-7C alkoxycarbonyl and/or CN; (c) 5- or 6-membered monocyclic satd. heterocyclyl; (d) amino opt. mono- or disubstd. by 1-3C alkyl; and (e) 2-4C alkoxycarbonyl; tetrahydronaphthyl; phenyl*; phenyl substd. by 1-3 f 1-4C alkyl, 1-4C haloalkyl, halo*, NO2, SO2NH2, amidino, guanidino, 1-3C alkoxy, methylenedioxy, OH, COOH, CN, 2-4C alkoxycarbonyl, CH=CHCOOR (R = H or 1-3C alkyl), NH2 and/or NHQ(Q = a gp. of formula (I) minus NR1R2); naphthyl*; naphthyl substd. by one or more of the above phenyl substits.; heteroaryl opt. substd. by one or more of phenyl, benzyl and the above phenyl substits.; or NR1R2 = a 4-7-membered ring* or a 5- 7-membered ring in which a C atom is replaced by O, N, NPh or NQ; X, Y = H, 1-6C alkyl, 1-6C alkoxy, 3-6C alkenyloxy, OPh or OH. Also claimed are : (A) cpds. (I) where the asterisked definitions are omitted; (B) cpds. (I) where R1 = phenyl or mono-, di- or trihalophenyl, R2 = H and X and Y are as above but not alkoxy.

公开(公告)号：NO880407L

公开(公告)日：1988-08-01

申请号：NO880407

申请日：1988-01-29

Applicant: HOECHST AG

Inventor： WOLF ERHARD ,  ROSSMANITH ERHARD ,  BARTLETT ROBERT R ,  SCHLEYERBACH RUDOLF

IPC: A61K31/55 ,  A61P29/00 ,  A61P37/00 ,  C07D243/08 ,  C07D295/18

Abstract: 1-(4-Hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine and various derivatives thereof substituted on the nitrogen are prepared starting from 4-hydroxy-3,5-di-tert.-butylbenzoic acid or its derivatives and homopiperazine or appropriate derivatives thereof. The compounds and their physiologically tolerated acid addition salts are suitable for the treatment of inflammatory and painful, in particular inflammatory rheumatic, disorders.

公开(公告)号：FI880387A

公开(公告)日：1988-07-31

申请号：FI880387

申请日：1988-01-28

Applicant: HOECHST AG

Inventor： WOLF ERHARD ,  ROSSMANITH ERHARD ,  BARTLETT ROBERT R ,  SCHLEYERBACH RUDOLF

IPC: A61K31/55 ,  A61P29/00 ,  A61P37/00 ,  C07D243/08 ,  C07D

Abstract: 1-(4-Hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine and various derivatives thereof substituted on the nitrogen are prepared starting from 4-hydroxy-3,5-di-tert.-butylbenzoic acid or its derivatives and homopiperazine or appropriate derivatives thereof. The compounds and their physiologically tolerated acid addition salts are suitable for the treatment of inflammatory and painful, in particular inflammatory rheumatic, disorders.

公开(公告)号：FI880387A0

公开(公告)日：1988-01-28

申请号：FI880387

申请日：1988-01-28

Applicant: HOECHST AG

Inventor： WOLF ERHARD ,  ROSSMANITH ERHARD ,  BARTLETT ROBERT R ,  SCHLEYERBACH RUDOLF

IPC: A61K31/55 ,  A61P29/00 ,  A61P37/00 ,  C07D243/08 ,  C07D

Abstract: 1-(4-Hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine and various derivatives thereof substituted on the nitrogen are prepared starting from 4-hydroxy-3,5-di-tert.-butylbenzoic acid or its derivatives and homopiperazine or appropriate derivatives thereof. The compounds and their physiologically tolerated acid addition salts are suitable for the treatment of inflammatory and painful, in particular inflammatory rheumatic, disorders.

公开(公告)号：PT86657B

公开(公告)日：1992-02-28

申请号：PT8665788

申请日：1988-01-28

Applicant: HOECHST AG

Inventor： SCHLEYERBACH RUDOLF ,  BARTLETT ROBERT R ,  WOLF ERHARD ,  ROSSMANITH ERHARD

IPC: A61K31/55 ,  A61P29/00 ,  A61P37/00 ,  C07D243/08

Abstract: 1-(4-Hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine and various derivatives thereof substituted on the nitrogen are prepared starting from 4-hydroxy-3,5-di-tert.-butylbenzoic acid or its derivatives and homopiperazine or appropriate derivatives thereof. The compounds and their physiologically tolerated acid addition salts are suitable for the treatment of inflammatory and painful, in particular inflammatory rheumatic, disorders.

公开(公告)号：ZA8800642B

公开(公告)日：1988-09-28

申请号：ZA8800642

申请日：1988-01-29

Applicant: HOECHST AG

Inventor： WOLF ERHARD ,  ERHARD WOLF ,  ROSSMANITH ERHARD ,  ERHARD ROSSMANITH ,  BARTLETT ROBERT R ,  ROBERT R BARTLETT ,  CHLEYERBACH RUDOLF ,  RUDOLF CHLEYERBACH

IPC: A61K31/55 ,  A61P29/00 ,  A61P37/00 ,  C07D243/08 ,  C07D ,  A61K ,  C07C

CPC classification number: C07D243/08

公开(公告)号：AU1099988A

公开(公告)日：1988-08-04

申请号：AU1099988

申请日：1988-01-29

Applicant: HOECHST AG

Inventor： WOLF ERHARD ,  ROSSMANITH ERHARD ,  BARTLETT ROBERT R ,  SCHLEYERBACH RUDOLF

IPC: A61K31/55 ,  A61P29/00 ,  A61P37/00 ,  C07D243/08

Abstract: 1-(4-Hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine and various derivatives thereof substituted on the nitrogen are prepared starting from 4-hydroxy-3,5-di-tert.-butylbenzoic acid or its derivatives and homopiperazine or appropriate derivatives thereof. The compounds and their physiologically tolerated acid addition salts are suitable for the treatment of inflammatory and painful, in particular inflammatory rheumatic, disorders.

公开(公告)号：ZA957674B

公开(公告)日：1996-04-15

申请号：ZA957674

申请日：1995-09-13

Applicant: HOECHST AG

Inventor： WOLF ERHARD ,  ROSSMANITH ERHARD ,  THORWART WERNER ,  RAISS RUTH ,  WEITHMAN KLAUS ULRICH

IPC: A61K31/66 ,  A61K31/665 ,  A61K31/675 ,  A61P29/00 ,  A61P43/00 ,  C07F9/30 ,  C07F9/32 ,  C07F9/38 ,  C07F9/40 ,  C07F9/48 ,  C07F9/58 ,  C07F9/59 ,  C07F9/6509 ,  C07F9/6512 ,  C07F9/6533 ,  C07F9/655 ,  C07F ,  A61K

Abstract: Medicaments contg. alpha-amino-3,5-di-t-butyl-4-hydroxybenzyl- phosphorus cpds. of formula (I) or their salts or stereoisomers are new: R1, R2 = H, 1-12C alkyl*, 1-12C alkyl (substd. by one or more of (a) phenyl*; (b) phenyl substd. by 1-3 halo, 1-3C alkyl, 1-3C alkoxy, methylenedioxy, NO2, NH2, amidino, guanidino, OH, 2-7C alkoxycarbonyl and/or CN; (c) 5- or 6-membered monocyclic satd. heterocyclyl; (d) amino opt. mono- or disubstd. by 1-3C alkyl; and (e) 2-4C alkoxycarbonyl; tetrahydronaphthyl; phenyl*; phenyl substd. by 1-3 f 1-4C alkyl, 1-4C haloalkyl, halo*, NO2, SO2NH2, amidino, guanidino, 1-3C alkoxy, methylenedioxy, OH, COOH, CN, 2-4C alkoxycarbonyl, CH=CHCOOR (R = H or 1-3C alkyl), NH2 and/or NHQ(Q = a gp. of formula (I) minus NR1R2); naphthyl*; naphthyl substd. by one or more of the above phenyl substits.; heteroaryl opt. substd. by one or more of phenyl, benzyl and the above phenyl substits.; or NR1R2 = a 4-7-membered ring* or a 5- 7-membered ring in which a C atom is replaced by O, N, NPh or NQ; X, Y = H, 1-6C alkyl, 1-6C alkoxy, 3-6C alkenyloxy, OPh or OH. Also claimed are : (A) cpds. (I) where the asterisked definitions are omitted; (B) cpds. (I) where R1 = phenyl or mono-, di- or trihalophenyl, R2 = H and X and Y are as above but not alkoxy.

公开(公告)号：DE3865443D1

公开(公告)日：1991-11-21

申请号：DE3865443

申请日：1988-01-26

Applicant: HOECHST AG

Inventor： WOLF ERHARD DR ,  ROSSMANITH ERHARD ,  BARTLETT ROBERT R DR ,  SCHLEYERBACH RUDOLF DR

IPC: A61K31/55 ,  A61P29/00 ,  A61P37/00 ,  C07D243/08

Abstract: 1-(4-Hydroxy-3,4-di-tert. -butyl-benzoyl) -homopiperazine derivs. of formula (I) and their physiologically tolerable acid addn. salts are new. R1=H, (1-6C alkoxy) carbonyl, or opt. nuclear-substd. benzoyloxycarbonyl.

公开(公告)号：HUT46683A

公开(公告)日：1988-11-28

申请号：HU39088

申请日：1988-01-28

Applicant: HOECHST AG

Inventor： WOLF ERHARD ,  ROSSMANITH ERHARD ,  BARTLETT ROBERT R ,  SCHLEYERBACH RUDOLF

IPC: A61K31/55 ,  A61P29/00 ,  A61P37/00 ,  C07D243/08 ,  C07D295/18

Abstract: 1-(4-Hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine and various derivatives thereof substituted on the nitrogen are prepared starting from 4-hydroxy-3,5-di-tert.-butylbenzoic acid or its derivatives and homopiperazine or appropriate derivatives thereof. The compounds and their physiologically tolerated acid addition salts are suitable for the treatment of inflammatory and painful, in particular inflammatory rheumatic, disorders.