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    PROCESS FOR THE MANUFACTURE OF AMINOAZETIDINONES
    2.
    发明专利
    PROCESS FOR THE MANUFACTURE OF AMINOAZETIDINONES 未知

    公开(公告)号：CA1001616A

    公开(公告)日：1976-12-14

    申请号：CA171107

    申请日：1973-05-04

    Applicant: HOECHST AG

    Inventor： BORMANN DIETER ,  SCHORR MANFRED ,  SCHMITT WILFRIED

    IPC: C07D499/04 ,  C07D499/00 ,  C07D499/06 ,  C07D499/10 ,  C07D499/42 ,  C07D501/04 ,  C07D501/18

    Abstract: 1431486 Preparing 6-aminopenicillanic acid and 7-aminocephalosporanic acids HOECHST AG 7 May 1973 [5 May 1972] 21586/73 Heading C2C 6-Amino-penicillanic acid and 7-amino-cephalosporanic acids, having the general Formula (I) in which Z is a group (Ia) or (Ib) wherein A is hydrogen or an acyloxy, alkyloxy or hydroxy group, are prepared by reacting a salt of an acylamino-penicillanic or cephalosporanic acid of general Formula (II) wherein Z is a group (Ia) or (Ib) as defined above and R is hydrogen or an unsubstituted or substituted alkyl, aryl, aralkyl, aryloxyalkyl or heterocyclic radical, in an inert solvent under anhydrous conditions with a phosphinic acid halide of Formula (III) wherein R 1 and R 2 are the same or different and each is an alkyl, cycloalkyl or aryl radical, X is oxygen or sulphur, and Hal is a halogen atom, with the proviso that X is not oxygen when A in the group (Ib) is hydrogen, acetoxy or alkyloxy; reacting the resulting mixed anhydride with an imidohalide-forming agent under anhydrous conditions; converting the resulting imidohalide into an imino-ether by reaction with an alcohol; hydrolysing the iminoether with water to give the compound (I), and precipitating this compound from the reaction mixture by adjusting the pH to its isoelectric point.

    3.
    发明专利
    未知

    公开(公告)号：DE2222094A1

    公开(公告)日：1973-11-15

    申请号：DE2222094

    申请日：1972-05-05

    Applicant: HOECHST AG

    Inventor： SCHMITT WILFRIED ,  BORMANN DIETER DIPL-CHEM DR ,  SCHORR MANFRED DIPL-CHEM DR

    IPC: C07D499/04 ,  C07D499/00 ,  C07D499/06 ,  C07D499/10 ,  C07D499/42 ,  C07D501/04 ,  C07D501/18 ,  C07D25/00

    Abstract: 1431486 Preparing 6-aminopenicillanic acid and 7-aminocephalosporanic acids HOECHST AG 7 May 1973 [5 May 1972] 21586/73 Heading C2C 6-Amino-penicillanic acid and 7-amino-cephalosporanic acids, having the general Formula (I) in which Z is a group (Ia) or (Ib) wherein A is hydrogen or an acyloxy, alkyloxy or hydroxy group, are prepared by reacting a salt of an acylamino-penicillanic or cephalosporanic acid of general Formula (II) wherein Z is a group (Ia) or (Ib) as defined above and R is hydrogen or an unsubstituted or substituted alkyl, aryl, aralkyl, aryloxyalkyl or heterocyclic radical, in an inert solvent under anhydrous conditions with a phosphinic acid halide of Formula (III) wherein R 1 and R 2 are the same or different and each is an alkyl, cycloalkyl or aryl radical, X is oxygen or sulphur, and Hal is a halogen atom, with the proviso that X is not oxygen when A in the group (Ib) is hydrogen, acetoxy or alkyloxy; reacting the resulting mixed anhydride with an imidohalide-forming agent under anhydrous conditions; converting the resulting imidohalide into an imino-ether by reaction with an alcohol; hydrolysing the iminoether with water to give the compound (I), and precipitating this compound from the reaction mixture by adjusting the pH to its isoelectric point.

    4.
    发明专利
    未知

    公开(公告)号：DE3536028A1

    公开(公告)日：1987-04-09

    申请号：DE3536028

    申请日：1985-10-09

    Applicant: HOECHST AG

    Inventor： SCHORR MANFRED DR ,  SCHMITT WILFRIED

    IPC: C07D207/26 ,  C07D207/267 ,  C07D211/76 ,  C07D223/10 ,  C07D225/02

    Abstract: A process for the preparation of 1-substituted azacycloalkan-2-ones of the formula I I in which R, m and n have the meanings indicated by reaction of corresponding 1-trimethylsilylazacycloalkan-2-ones with alkali metal alcoholate or alkali metal oxide and then alkylation of the alkali metal salts which are formed.

    5.
    发明专利
    未知

    公开(公告)号：DE2457464A1

    公开(公告)日：1976-06-10

    申请号：DE2457464

    申请日：1974-12-05

    Applicant: HOECHST AG

    Inventor： SCHORR MANFRED DIPL CHEM DR ,  SCHRINNER ELMAR DR ,  SCHMITT WILFRIED

    IPC: C07D499/00 ,  C07D499/46 ,  C07D499/64 ,  C07D499/70

    Abstract: Acylaminopenicillanic acids of the general formula in which A represents phenyl which may be substituted, an aromatic monocyclic heterocycle which may be substituted or dihydrophenyl, and X represents one of the groups -SO2-, -CO-, -P(R)- or -P(O)(R)- in which R represents low molecular weight alkyl, alkenyl, alkoxy, aralkyl, aralkoxy, aryl or aryloxy which may be substituted, non-toxic salts of these compounds and pharmaceutical compositions containing these compounds.

    7.
    发明专利
    未知

    公开(公告)号：DE2458973A1

    公开(公告)日：1976-06-16

    申请号：DE2458973

    申请日：1974-12-13

    Applicant: HOECHST AG

    Inventor： SCHORR MANFRED DIPL CHEM DR ,  SCHRINNER ELMAR DR ,  SCHMITT WILFRIED

    IPC: C07D499/66 ,  C07D499/00 ,  C07D499/64 ,  C07D499/68 ,  C07D499/70

    Abstract: Acylaminopenicillanic acids of the general formula in which R1, R2 and R3 represent hydrogen or lower alkyl which may be substituted, and in which the radicals R1 and R2 or R2 and R3 may form together an alkylene radical which may be substituted, R4 and R5 represent hydrogen or lower alkyl, R6 represents phenyl which may be substituted, a monocyclic aromatic heterocycle which may be substituted, or dihydrophenyl, A represents a benzene or thiophene ring which may be substituted, and X represents oxygen or a single bond, a process for preparing them and pharmaceutical compositions active against bacterial infections containing these compounds.

    8.
    发明专利
    未知

    公开(公告)号：FI753496A

    公开(公告)日：1976-06-14

    申请号：FI753496

    申请日：1975-12-11

    Applicant: HOECHST AG

    Inventor： SCHORR MANFRED ,  SCHRINNER ELMAR ,  SCHMITT WILFRIED

    IPC: C07D499/66 ,  C07D499/00 ,  C07D499/64 ,  C07D499/68 ,  C07D499/70 ,  C07D

    Abstract: Acylaminopenicillanic acids of the general formula in which R1, R2 and R3 represent hydrogen or lower alkyl which may be substituted, and in which the radicals R1 and R2 or R2 and R3 may form together an alkylene radical which may be substituted, R4 and R5 represent hydrogen or lower alkyl, R6 represents phenyl which may be substituted, a monocyclic aromatic heterocycle which may be substituted, or dihydrophenyl, A represents a benzene or thiophene ring which may be substituted, and X represents oxygen or a single bond, a process for preparing them and pharmaceutical compositions active against bacterial infections containing these compounds.

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