公开(公告)号：ES2057071T3

公开(公告)日：1994-10-16

申请号：ES89121498

申请日：1989-11-21

Applicant: HOECHST AG

Inventor： HENKE STEPHAN DR ,  ANAGNOSTOPULOS HIRISTO ,  BREIPOHL GERHARD DR ,  KNOLLE JOCHEN DR ,  STECHEL JENS DR ,  SCHOLKENS BERNWARD PROF DR ,  FEHLHABER HANS-WOLFRAM DR

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18 ,  C07K99/20

Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aromatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5 and K is a radical -NH(CH2)-1-4-CO- or is a direct bond, have bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are promoted, induced or sustained by bradykinin and bradykinin- related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

公开(公告)号：DE58907889D1

公开(公告)日：1994-07-21

申请号：DE58907889

申请日：1989-11-21

Applicant: HOECHST AG

Inventor： HENKE STEPHAN DR ,  ANAGNOSTOPULOS HIRISTO ,  BREIPOHL GERHARD DR ,  KNOLLE JOCHEN DR ,  STECHEL JENS DR ,  SCHOELKENS BERNWARD PROF DR ,  FEHLHABER HANS-WOLFRAM DR

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18 ,  C07K99/20

Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aromatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5 and K is a radical -NH(CH2)-1-4-CO- or is a direct bond, have bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are promoted, induced or sustained by bradykinin and bradykinin- related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

公开(公告)号：AT107318T

公开(公告)日：1994-07-15

申请号：AT89121498

申请日：1989-11-21

Applicant: HOECHST AG

Inventor： HENKE STEPHAN DR ,  ANAGNOSTOPULOS HIRISTO ,  BREIPOHL GERHARD DR ,  KNOLLE JOCHEN DR ,  STECHEL JENS DR ,  SCHOELKENS BERNWARD PROF DR ,  FEHLHABER HANS-WOLFRAM DR

IPC: A61K38/17 ,  A61K38/00 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18 ,  C07K99/20

Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aromatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5 and K is a radical -NH(CH2)-1-4-CO- or is a direct bond, have bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are promoted, induced or sustained by bradykinin and bradykinin- related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.