公开(公告)号：KR800001418B1

公开(公告)日：1980-12-05

申请号：KR760001766

申请日：1976-07-21

Applicant: HOECHST AG

Inventor： RAETHER W ,  WINKELMAN E

IPC: A61K31/41 ,  C07D233/70

Abstract: Title compds.(I; A = S, sulfoxide group, R1 = methyl, or ethyl; R2 = methyl, halogen), useful as protozoacides, were prepd. by reaction of nitroimidazole(II; X = halogen, acyloxy group, arylsulfonyloxy group) with phenol or its alkaline metal salt or ammonium salt(III; Y = H, alkaline metal, ammonium) followed by oxidation of intermediate sulfide compd. Thus, K2CO3 13.8 g and 1-methyl-2-chloromethyl-5-nitroimidazole 17.6 g were added in the 3-methyl-4-methylmercaptophenol 15.4 g in dimethylformamide 30ml soln. and stirred for1hr at 25≦̸C to give 1-methyl-2-(3-methyl-4-methylthiophenyl-oxymethyl)-5-nitroimidazole 21.7g.