公开(公告)号：HK1205757A1

公开(公告)日：2015-12-24

申请号：HK15106269

申请日：2015-07-02

Applicant: HOFFMANN LA ROCHE

Inventor： DFEL HARTMUT ,  MEIER THOMAS ,  TACKE MICHAEL

IPC: C12N20060101

Abstract: Compositions, devices, kits and methods are disclosed for assaying glucose with a glycosylated, modified flavin adenine dinucleotide-dependent glucose dehydrogenase (FAD-GDH), variant thereof or an active fragment thereof, where at least one asparagine residue at positions N2, N168 and N346 of mature, wild-type A. oryzae FAD-GDH according to SEQ ID NO:2 is substituted by one or more amino acids not suitable for glycosylation, thereby eliminating or inactivating, respectively, a potential glycosylation site at this position.