公开(公告)号：BR0214488A

公开(公告)日：2004-10-19

申请号：BR0214488

申请日：2002-11-21

Applicant: HOFFMANN LA ROCHE

Inventor： FLOUHR ALEXANDER ,  JAKOB-ROETNE ROLAND ,  NORCROSS ROGER DAVID ,  RIEMER CLAUS

IPC: A61K31/428 ,  A61K31/5377 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P21/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/36 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D277/82 ,  C07D417/12

Abstract: The present invention relates to compounds of the formulawherein R and R are as defined herewithin. The compounds of formula I have been found to be adenosine receptor ligands. Specifically, the compounds of the present invention have a good affinity to the A2A-receptor and they are therefore useful in the treatment of diseases, related to this receptor.