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公开(公告)号：KR20180070611A
公开(公告)日：2018-06-26
申请号：KR20187013292
申请日：2016-11-11
Applicant: HOFFMANN LA ROCHE
Inventor： COSTA VERONICA , HEDTJARN MAJ , HOENER MARIUS , JAGASIA RAVI , JENSEN MADS AABOE , PATSCH CHRISTOPH , PEDERSEN LYKKE , RASMUSSEN SOREN VESTERGAARD
IPC: C12N15/113 , A61K31/7088 , A61P25/00
CPC classification number: C12N15/1137 , C12N5/0619 , C12N5/0623 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/33 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/34 , C12N2500/38 , C12N2500/44 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/41 , C12N2501/60 , C12N2501/727 , C12N2501/999 , C12N2503/02 , C12N2506/45 , C12N2533/52 , G01N33/5014 , G01N33/5058
Abstract: 본발명은동물또는인간뉴런에서부계대립유전자로부터유비퀴틴-단백질리가제 E3A(UBE3A)의발현을유도할수 있는올리고뉴클레오티드에관한것이다. 상기올리고뉴클레오티드는 SNORD109B 하류의 SNHG14 긴비-암호화 RNA에하이브리드화됨으로써 UBE3A 부계대립유전자의억제유전자를표적화한다. 본발명은또한엔젤만증후군의치료를위한약학조성물및 방법에관한것이다.
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公开(公告)号：KR20200137027A
公开(公告)日：2020-12-08
申请号：KR20207033999
申请日：2016-11-11
Applicant: HOFFMANN LA ROCHE
Inventor： COSTA VERONICA , HEDTJARN MAJ , HOENER MARIUS , JAGASIA RAVI , JENSEN MADS AABOE , PATSCH CHRISTOPH , PEDERSEN LYKKE , RASMUSSEN SOREN VESTERGAARD
IPC: C12N15/113 , A61K31/7088 , A61P25/00
Abstract: 본발명은동물또는인간뉴런에서부계대립유전자로부터유비퀴틴-단백질리가제 E3A(UBE3A)의발현을유도할수 있는올리고뉴클레오티드에관한것이다. 상기올리고뉴클레오티드는 SNORD109B 하류의 SNHG14 긴비-암호화 RNA에하이브리드화됨으로써 UBE3A 부계대립유전자의억제유전자를표적화한다. 본발명은또한엔젤만증후군의치료를위한약학조성물및 방법에관한것이다.
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3.发明申请CONVERSION OF SOMATIC CELLS TO INDUCED REPROGRAMMED NEURAL STEM CELLS (IRNSCS) 审中-公开诱导的神经干细胞（IRNSCS）诱导的神经细胞转化
公开(公告)号：WO2012022725A3
公开(公告)日：2012-04-12
申请号：PCT/EP2011064051
申请日：2011-08-16
Applicant: HOFFMANN LA ROCHE , CHRISTENSEN KLAUS , GRAF MARTIN , IACONE ROBERTO , JAGASIA RAVI
Inventor： CHRISTENSEN KLAUS , GRAF MARTIN , IACONE ROBERTO , JAGASIA RAVI
IPC: C12N5/0797
CPC classification number: C12N5/0623 , A61K35/30 , C12N15/86 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/405 , C12N2501/60 , C12N2501/602 , C12N2501/727 , C12N2506/1307 , C12N2510/00
Abstract: This application relates to a method for converting somatic cells to Neural Stem Cells (NSCs). Moreover this application relates to a method for converting human fibroblasts, keratinocytes or adipocytes to neural stem cells based on linked steps of genes transduction and chemically defined medium induction.
Abstract translation: 本申请涉及将体细胞转化为神经干细胞（NSCs）的方法。 此外，本申请涉及基于基因转导和化学上确定的培养基诱导的连接步骤将人成纤维细胞，角质形成细胞或脂肪细胞转化为神经干细胞的方法。
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公开(公告)号：MA39027A1
公开(公告)日：2018-05-31
申请号：MA39027
申请日：2014-11-07
Applicant: HOFFMANN LA ROCHE , HOFFMANN LA ROCHE
Inventor： JAGASIA RAVI , JAKOB-ROETNE ROLAND , WICHMANN JUERGEN , PETERS JENS-UWE
IPC: A61K31/4985 , A61P25/18 , A61P25/22 , A61P25/24 , C07D471/04
Abstract: L'invention concerne des composés de formule générale (i), dans laquelle r
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公开(公告)号：MA39027B1
公开(公告)日：2018-10-31
申请号：MA39027
申请日：2014-11-07
Applicant: HOFFMANN LA ROCHE , HOFFMANN LA ROCHE
Inventor： JAGASIA RAVI , JAKOB-ROETNE ROLAND , WICHMANN JUERGEN , PETERS JENS-UWE
IPC: A61K31/4985 , A61P25/18 , A61P25/22 , A61P25/24 , C07D471/04
Abstract: L'invention concerne des composés de formule générale (i), dans laquelle r
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Patent Agency Ranking
公开(公告)号：EP3027597B1
公开(公告)日：2017-05-03
申请号：EP14744539
申请日：2014-07-28
Applicant: F HOFFMANN-LA ROCHE AG
Inventor： CECCARELLI SIMONA M , JAGASIA RAVI , JAKOB-ROETNE ROLAND , PETERS JENS-UWE , WICHMANN JUERGEN
IPC: C07D401/04 , A61K31/4375 , A61P25/00 , C07D498/04
CPC classification number: C07D471/04 , C07D401/04 , C07D498/04
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公开(公告)号：AU2020203573B2
公开(公告)日：2022-07-07
申请号：AU2020203573
申请日：2020-05-29
Applicant: HOFFMANN LA ROCHE
Inventor： COSTA VERONICA , HEDTJÄRN MAJ , HOENER MARIUS , JAGASIA RAVI , JENSEN MADS AABOE , PATSCH CHRISTOPH , PEDERSEN LYKKE , RASMUSSEN SØREN VESTERGAARD
IPC: C12N15/113 , C12N15/11
Abstract: The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.
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公开(公告)号：ES2852998T3
公开(公告)日：2021-09-14
申请号：ES16798440
申请日：2016-11-11
Applicant: HOFFMANN LA ROCHE
Inventor： COSTA VERONICA , HEDTJÄRN MAJ , HOENER MARIUS , JAGASIA RAVI , JENSEN MADS AABOE , PATSCH CHRISTOPH , PEDERSEN LYKKE , RASMUSSEN SØREN VESTERGAARD
IPC: C12N15/113 , A61K31/712 , A61K31/7125 , C12N15/11
Abstract: Un oligonucleótido antisentido en el que el oligonucleótido es el compuesto oligonucleotídico (CMP ID NO: 626_7) en el que las letras mayúsculas representan nucleósidos de LNA beta-D- oxi, las letras minúsculas representan nucleósidos de ADN, todos los C de LNA son 5-metil-citosina y todos los enlaces internucleosídicos son enlaces internucleosídicos de fosforotioato.
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公开(公告)号：SI3374509T1
公开(公告)日：2021-04-30
申请号：SI201631093
申请日：2016-11-11
Applicant: HOFFMANN LA ROCHE
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公开(公告)号：AU2016352836B2
公开(公告)日：2020-06-25
申请号：AU2016352836
申请日：2016-11-11
Applicant: HOFFMANN LA ROCHE
Inventor： COSTA VERONICA , HEDTJÄRN MAJ , HOENER MARIUS , JAGASIA RAVI , JENSEN MADS AABOE , PATSCH CHRISTOPH , PEDERSEN LYKKE , RASMUSSEN SØREN VESTERGAARD
IPC: C12N15/113 , C12N15/11
Abstract: The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.
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