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公开(公告)号：AU2020309307A1
公开(公告)日：2021-11-04
申请号：AU2020309307
申请日：2020-07-06
Applicant: HOFFMANN LA ROCHE
Inventor： CHOI YONG RAG , KANG YOUNGGOO , KIM SUNG WON , JUNG KYEONG EUN , SCHMIDT PASCAL
Abstract: The invention relates to a new process for the purification of oligonucleotides which comprises the removal of an acid labile 5'hydroxy protecting group at the 5'- O-oligonucleotide terminus of the oligonucleotide by means of an on-column de-protection with an acid.
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公开(公告)号：AU2020292763B2
公开(公告)日：2022-12-08
申请号：AU2020292763
申请日：2020-06-09
Applicant: HOFFMANN LA ROCHE
Inventor： FETTES ALEC , GEISER ACHIM , JAITZ LEONHARD , CHOI HONGRIM , JUNG KYEONG EUN , KIM SUNG WON
Abstract: The invention relates to a process for the production of a mixed P=O/P=S backbone oligonucleotide comprising a selective oxidation of an intermediary phosphite triester compound of formula I into a phosphodiester compound of formula II according to the scheme with an oxidation solution obtained by mixing iodine, an organic solvent and water, characterized in that the oxidation solution has been aged for a time period that is sufficient to selectively oxidize the phosphite triester compound of formula I into the phosphodiester compound of formula II without oxidizing the phosphorothioate intenucleotide linkages.
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Patent Agency Ranking
公开(公告)号：AU2020292763A1
公开(公告)日：2022-01-20
申请号：AU2020292763
申请日：2020-06-09
Applicant: HOFFMANN LA ROCHE
Inventor： FETTES ALEC , GEISER ACHIM , JAITZ LEONHARD , CHOI HONGRIM , JUNG KYEONG EUN , KIM SUNG WON
Abstract: The invention relates to a process for the production of a mixed P=O/P=S backbone oligonucleotide comprising a selective oxidation of an intermediary phosphite triester compound of formula I into a phosphodiester compound of formula II according to the scheme with an oxidation solution obtained by mixing iodine, an organic solvent and water, characterized in that the oxidation solution has been aged for a time period that is sufficient to selectively oxidize the phosphite triester compound of formula I into the phosphodiester compound of formula II without oxidizing the phosphorothioate intenucleotide linkages.
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4.发明专利
公开(公告)号：MX2021015197A
公开(公告)日：2022-01-18
申请号：MX2021015197
申请日：2020-06-09
Applicant: HOFFMANN LA ROCHE
Inventor： KIM SUNG WON , FETTES ALEC , GEISER ACHIM , JAITZ LEONHARD , CHOI HONGRIM , JUNG KYEONG EUN
Abstract: La invención se refiere a un proceso para la producción de un oligonucleótido de cadena principal P=O/P=S mixta que comprende una oxidación selectiva de un compuesto de triéster de fosfito intermediario de la fórmula I hasta un compuesto de fosfodiéster de la fórmula II de acuerdo con el esquema de reacción, (ver Fórmulas) con una solución de oxidación obtenida al mezclar yodo, un solvente orgánico y agua, en donde la solución de oxidación se ha envejecido durante un período que es suficiente para oxidar selectivamente el compuesto de triéster de fosfito de la fórmula I hasta el compuesto de fosfodiéster de la fórmula II sin oxidar los enlaces internucleotídicos de fosforotioato.
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公开(公告)号：CA3141195C
公开(公告)日：2023-12-19
申请号：CA3141195
申请日：2020-06-09
Applicant: HOFFMANN LA ROCHE
Inventor： FETTES ALEC , GEISER ACHIM , JAITZ LEONHARD , CHOI HONGRIM , JUNG KYEONG EUN , KIM SUNG WON
Abstract: The invention relates to a process for the production of a mixed P=O/P=S backbone oligonucleotide comprising a selective oxidation of an intermediary phosphite triester compound of formula I into a phosphodiester compound of formula II according to the scheme with an oxidation solution obtained by mixing iodine, an organic solvent and water, characterized in that the oxidation solution has been aged for a time period that is sufficient to selectively oxidize the phosphite triester compound of formula I into the phosphodiester compound of formula II without oxidizing the phosphorothioate intenucleotide linkages.
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公开(公告)号：CA3139610A1
公开(公告)日：2021-01-14
申请号：CA3139610
申请日：2020-07-06
Applicant: HOFFMANN LA ROCHE
Inventor： CHOI YONG RAG , KANG YOUNGGOO , KIM SUNG WON , JUNG KYEONG EUN , SCHMIDT PASCAL
Abstract: The invention relates to a new process for the purification of oligonucleotides which comprises the removal of an acid labile 5'hydroxy protecting group at the 5'- O-oligonucleotide terminus of the oligonucleotide by means of an on-column de-protection with an acid.
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公开(公告)号：CA3141195A1
公开(公告)日：2020-12-17
申请号：CA3141195
申请日：2020-06-09
Applicant: HOFFMANN LA ROCHE
Inventor： FETTES ALEC , GEISER ACHIM , JAITZ LEONHARD , CHOI HONGRIM , JUNG KYEONG EUN , KIM SUNG WON
Abstract: The invention relates to a process for the production of a mixed P=O/P=S backbone oligonucleotide comprising a selective oxidation of an intermediary phosphite triester compound of formula I into a phosphodiester compound of formula II according to the scheme with an oxidation solution obtained by mixing iodine, an organic solvent and water, characterized in that the oxidation solution has been aged for a time period that is sufficient to selectively oxidize the phosphite triester compound of formula I into the phosphodiester compound of formula II without oxidizing the phosphorothioate intenucleotide linkages.
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