Chimpanzee trace amine associated receptor
    5.
    发明专利
    Chimpanzee trace amine associated receptor 审中-公开
    CHIMPANZEE跟踪胺相关受体

    公开(公告)号:JP2006068001A

    公开(公告)日:2006-03-16

    申请号:JP2005222512

    申请日:2005-08-01

    CPC classification number: C07K14/70571 C07K14/705 G01N2500/04

    Abstract: PROBLEM TO BE SOLVED: To provide a TAAR (trace amine associated receptor) of a chimpanzee, forming a subfamily of a G-protein coupled receptor. SOLUTION: The new TAAR polypeptide of the chimpanzee is identified as a member of the subfamily of the G-protein coupled receptor, and a fingerprint sequence specific and selective for the TAAR polypeptide is provided. Furthermore, a nucleic acid encoding the TAAR polypeptide and a vector and a host cell containing the family member are provided. In addition, a method for identifying the TAAR of the chimpanzee is provided. COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 待解决的问题:提供黑猩猩的TAAR(微量胺相关受体),形成G蛋白偶联受体的亚家族。 解决方案:将黑猩猩的新TAAR多肽鉴定为G蛋白偶联受体亚科的成员,并提供对TAAR多肽特异性和选择性的指纹序列。 此外,提供了编码TAAR多肽的核酸和载体以及含有家族成员的宿主细胞。 另外,提供了一种用于识别黑猩猩的TAAR的方法。 版权所有(C)2006,JPO&NCIPI

    대사형 글루타메이트 수용체 조절제로서의 에틴일 유도체
    6.
    发明公开
    대사형 글루타메이트 수용체 조절제로서의 에틴일 유도체 审中-公开
    乙炔基衍生物作为代谢型谷氨酸受体调节剂

    公开(公告)号:KR20180026438A

    公开(公告)日:2018-03-12

    申请号:KR20187000004

    申请日:2016-07-11

    Abstract: 본발명은하기화학식 I의화합물, 또는이의약학적으로허용되는염 또는산 부가염, 라세미체혼합물, 또는이의상응하는거울상이성질체및/또는광학이성질체및/또는입체이성질체에관한것이다: [화학식 I]상기식에서, R은저급알킬이고; R는페닐또는피리딘일이고, 여기서피리딘일기 내의 N 원자는상이한위치에존재할수 있고; n은 0, 1 또는 2이고; V 및 U는서로독립적으로 O 또는 CH이고, 여기서 V 및 U는동시에 O일수 없고; L은하기로부터선택되는 5원또는 6원헤테로아릴기이다:. 상기화합물은파킨슨병, 불안, 구토, 강박장애, 자폐증, 신경보호, 암, 우울증및 2형당뇨병의치료에사용될수 있다.

    Abstract translation: 本发明涉及式(I)化合物或其药学上可接受的盐或酸加成盐,外消旋混合物或其相应的对映异构体和/或旋光异构体和/或立体异构体: I]其中R是低级烷基; R为苯基或吡啶基,其中吡啶基团中的N原子可以位于不同的位置; n是0,1或2; V和U彼此独立地为O或CH,其中V和U不能同时为O; L是选自由以下组成的组的5或6元杂芳基: 这类化合物可用于治疗帕金森病,焦虑症,呕吐,强迫症,自闭症,神经保护,癌症,抑郁症和2型糖尿病。

    RAT TRACE AMINE ASSOCIATED RECEPTORS
    7.
    发明申请
    RAT TRACE AMINE ASSOCIATED RECEPTORS 审中-公开
    大鼠追踪胺相关受体

    公开(公告)号:WO2006005473A2

    公开(公告)日:2006-01-19

    申请号:PCT/EP2005007187

    申请日:2005-07-04

    CPC classification number: C07K14/723

    Abstract: The present invention provides a fingerprint sequence which is specific and selective for rat trace amine associated receptors (TAAR) forming a subfamily of G protein coupled receptors. The invention also provides the novel rat polypeptides identified as members of this family, nucleic acids encoding said polypeptides, and vectors and host cells comprising the novel family members. In addition, the invention provides methods of identifying rat TAARs.

    Abstract translation: 本发明提供了对形成G蛋白偶联受体亚家族的大鼠痕量胺相关受体(TAAR)具有特异性和选择性的指纹序列。 本发明还提供了鉴定为该家族成员的新型大鼠多肽,编码所述多肽的核酸以及包含新家族成员的载体和宿主细胞。 另外,本发明提供了鉴定大鼠TAAR的方法。

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