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公开(公告)号:DK126195B
公开(公告)日:1973-06-18
申请号:DK131470
申请日:1970-03-17
Applicant: HOFFMANN LA ROCHE
Inventor: SCHAEREN S
IPC: C07D213/67 , C07D491/04 , C07D491/056 , C07D498/18 , C07D31/28
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公开(公告)号:DK119430B
公开(公告)日:1971-01-04
申请号:DK568268
申请日:1968-11-21
Applicant: HOFFMANN LA ROCHE
Inventor: SCHAEREN S
IPC: C07F9/58
Abstract: 1,189,545. Pyridoxin-5 1 -phosphate. F. HOFFMANN-LA ROCHE & CO. A.G. 12 Dec., 1968 [15 Dec., 1967], No. 59070/68. Heading C2V. Pyridoxin-5 1 -phosphate is obtained by reacting an acetal or ketal of formula where R 1 and R 2 are hydrogen atoms, alkyl, alkenyl or aryl groups or together form an alkylene group, or an acid addition salt of such a compound, with polyphosphoric acid and hydrolysing the polyphosphate thus obtained by addition of water. Examples are given.
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公开(公告)号:SE324365B
公开(公告)日:1970-06-01
申请号:SE820165
申请日:1965-06-21
Applicant: HOFFMANN LA ROCHE
Inventor: SCHAEREN S
IPC: C07D263/42 , C07D85/44
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公开(公告)号:SE366547B
公开(公告)日:1974-04-29
申请号:SE421970
申请日:1970-03-25
Applicant: HOFFMANN LA ROCHE
Inventor: SCHAEREN S
IPC: C07D263/42 , C07D85/44
Abstract: A process for the preparation of 4-methyl-5-alkoxy-oxazoles from 5-alkoxy-4-oxazolylacetic acids, which products are useful as intermediates for the preparation of pyridoxine. The starting materials are heated at a temperature of 100 DEG -150 DEG C. in the presence of a dienophile (A-HC=CH-B, wherein A and B are trans and each is an electron-withdrawing group) until evolution of CO2 ceases.
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公开(公告)号:NO121662B
公开(公告)日:1971-03-29
申请号:NO15824265
申请日:1965-05-26
Applicant: HOFFMANN LA ROCHE
Inventor: SCHAEREN S
IPC: C07D213/67 , C07D491/04
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公开(公告)号:DK125023B
公开(公告)日:1972-12-18
申请号:DK150470
申请日:1970-03-24
Applicant: HOFFMANN LA ROCHE
Inventor: SCHAEREN S
IPC: C07D263/42 , C07D85/44
Abstract: A process for the preparation of 4-methyl-5-alkoxy-oxazoles from 5-alkoxy-4-oxazolylacetic acids, which products are useful as intermediates for the preparation of pyridoxine. The starting materials are heated at a temperature of 100 DEG -150 DEG C. in the presence of a dienophile (A-HC=CH-B, wherein A and B are trans and each is an electron-withdrawing group) until evolution of CO2 ceases.
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公开(公告)号:SE349290B
公开(公告)日:1972-09-25
申请号:SE1335867
申请日:1967-09-28
Applicant: HOFFMANN LA ROCHE
Inventor: SCHAEREN S , FURLENMEIER A
IPC: C07C45/40 , C07C45/81 , C07C49/757 , C07C45/00 , C07C169/22 , C07C169/34
Abstract: Method for prepn. of carbonyl cpds. (R1, R2 & R3 = sec. amine residues, pref. from di-(1-7C)-alkylamines or heterocyclic amines). (a) The redn. proceeds at low temp., (b) high yield and the carbonyl group does not reduce further, (c) excess phosphine is readily removed by acid washing and (d) no additional solvent is required.
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公开(公告)号:SE335125B
公开(公告)日:1971-05-17
申请号:SE1666668
申请日:1968-12-05
Applicant: HOFFMANN LA ROCHE
Inventor: SCHAEREN S
Abstract: 1,189,545. Pyridoxin-5 1 -phosphate. F. HOFFMANN-LA ROCHE & CO. A.G. 12 Dec., 1968 [15 Dec., 1967], No. 59070/68. Heading C2V. Pyridoxin-5 1 -phosphate is obtained by reacting an acetal or ketal of formula where R 1 and R 2 are hydrogen atoms, alkyl, alkenyl or aryl groups or together form an alkylene group, or an acid addition salt of such a compound, with polyphosphoric acid and hydrolysing the polyphosphate thus obtained by addition of water. Examples are given.
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公开(公告)号:SE334359B
公开(公告)日:1971-04-26
申请号:SE697565
申请日:1965-05-26
Applicant: HOFFMANN LA ROCHE
Inventor: SCHAEREN S
IPC: C07D213/67 , C07D491/04 , C07D31/30
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