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    DERIVATI CEFALOSPORINA
    2.
    发明专利
    DERIVATI CEFALOSPORINA 未知

    公开(公告)号：YU19494A

    公开(公告)日：1998-05-15

    申请号：YU19494

    申请日：1994-04-14

    Applicant: HOFFMANN LA ROCHE

    Inventor： ANGEHRN P ,  WEI C C

    IPC: C07D501/00 ,  C07D501/24 ,  C07D501/56

    Abstract: DERIVATI CEFALOSPORINA - Derivati cefaiosporina opšte formule u kojoj označavaju R1 acil-grupu izvedenu iz karboksilne kiseline, R2 vodonik, hidroksi, niži alkil-Qm, cikioalkil, niži alkoksi, niži alkenil, cikloalkenil, niži alkinil, aralkil-Qm, aril-Qm, ariloksi, aralkoksi ili heterociklicni prsten, pri cemu su niži alkil, cikioalkil, niži alkoksi, niži alkenil, cikloalkenil, niži alkinil, aralkil, aril, ariloksi, aralkoksi i heterociklični prsten nesupstituisani ili supstituisani najmanje jednom grupom odabranom iz grupe karboksi, amino, nitro, cijan, niži alkil, niži aikoksi, hidroksi, halogen, -CONR4R5, -N(R5)COOR9, RECO-, R5OCO- ili R5COO- gde R4 označava vodonik, niži alkil, ili cikioalkil, R5 je vodonik ili niži alkil, F!s je vodonik, niži alkil, niži alkenil ili grupa koja štiti karboksilnu kiselinu,Q -CO- ili -S02-m O ili 1, n O, 1 ili 2,kao i njihovi lako hidrolizujući esstri, farmaceutski prihvatljive soli pomenutih jedinjenja i hidrati jedinjenja formule I i njihovih estara i soli. Produkti su antibakterijski aktivni.

    ACYL DERIVATIVES
    4.
    发明专利
    ACYL DERIVATIVES 未知

    公开(公告)号：YU63689A

    公开(公告)日：1991-06-30

    申请号：YU63689

    申请日：1989-03-28

    Applicant: HOFFMANN LA ROCHE

    Inventor： ALBRECHT H A ,  KEITH D D ,  KONZELMANN F M ,  RPSSMAN P L ,  WEI C C ,  WEIGELE M ,  YANG R

    IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/18 ,  C07D501/26 ,  C07D501/32 ,  C07D501/34 ,  C07D501/38 ,  C07D501/44 ,  C07D501/46 ,  C07D501/57 ,  C07D519/00 ,  C07D519/06 ,  C07D501/00

    Abstract: Acyl derivatives of the general formula in which R denotes a substituted N-heterocycle of the formulae in which R represents one of the groups and Q represents a substituted quinolinyl or naphthyridinyl group, where the N-heterocycle can optionally be substituted by one or more lower alkyl groups; and in which R additionally represents hydrogen, lower alkoxy, lower alkylthio or lower alkanoylamino, R represents an acyl group, m represents 0, 1 or 2 and A represents a pharmaceutically tolerable anion, and easily hydrolysable esters and pharmaceutically tolerable salts of these compounds and hydrates of the compounds of the formula I or of their esters and salts and a process for their preparation and pharmaceutical preparations which contain this compound, and also intermediates for the preparation of these compounds, and additionally the use of the compounds for the control of diseases and for the production of the preparations mentioned are described. The products have antibiotic activity.

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