公开(公告)号：WO2007075920A2

公开(公告)日：2007-07-05

申请号：PCT/US2006/048847

申请日：2006-12-22

Applicant: HONEYWELL INTERNATIONAL INC. ,  PADMANABHAN, Aravind ,  COX, James, A. ,  FRITZ, Bernard, S. ,  REZACHEK, Tom, M. ,  REUTIMAN, Peter, L. ,  BARDELL, Ron, L. ,  CABUZ, Cleopatra

Inventor： PADMANABHAN, Aravind ,  COX, James, A. ,  FRITZ, Bernard, S. ,  REZACHEK, Tom, M. ,  REUTIMAN, Peter, L. ,  BARDELL, Ron, L. ,  CABUZ, Cleopatra

CPC classification number: G01N35/00603 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502746 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0636 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0627 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/14 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0487 ,  G01N15/1404 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/53 ,  G01N29/032 ,  G01N33/5094 ,  G01N35/00663 ,  G01N2015/0069 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2035/00148 ,  G01N2035/00158 ,  G01N2035/00247 ,  G01N2035/1034 ,  G01N2035/1053 ,  G01N2291/02433 ,  G01N2291/02836 ,  G01N2291/02872

Abstract: A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduced risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.

Abstract translation: 与样品分析仪有关的系统，更具体地说，涉及操作简单且降低向使用者提供错误结果的风险的样品分析仪。 在一些情况下，样品分析仪可以是便携式样品分析仪，其包括一次性流体盒。 不需要对分析仪的操作员进行培训。

公开(公告)号：WO2005114142A2

公开(公告)日：2005-12-01

申请号：PCT/US2005/016769

申请日：2005-05-13

Applicant: HONEYWELL INTERNATIONAL, INC. ,  PADMANABHAN, Aravind ,  COX, James A. ,  FRITZ, Bernard S. ,  CABUZ, Cleopatra

Inventor： PADMANABHAN, Aravind ,  COX, James A. ,  FRITZ, Bernard S. ,  CABUZ, Cleopatra

IPC: G01N15/00

CPC classification number: G01N15/1404 ,  G01N2015/1413 ,  G01N2015/1486 ,  Y10T436/101666

Abstract: A sample analyzer with a removable and/or disposable cartridge for use at the point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.

Abstract translation: 具有可拆卸和/或一次性药筒的样品分析器，用于在患者的照顾点，例如在医生的办公室，家庭或现场的其他地方。 通过为所需的试剂和/或流体提供一个可拆卸的和/或一次性的墨盒，样品分析仪可以在实验室环境之外被可靠地使用，很少或没有专门的培训。

公开(公告)号：WO2004048948A1

公开(公告)日：2004-06-10

申请号：PCT/US2003/038153

申请日：2003-11-25

Applicant: HONEYWELL INTERNATIONAL, INC.

Inventor： PADMANABHAN, Aravind ,  FRITZ, Bernard, S. ,  CABUZ, Cleopatra

IPC: G01N21/64

CPC classification number: G01N15/147 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150343 ,  A61B5/150351 ,  A61B5/157 ,  A61B5/417 ,  B01L3/5027 ,  G01N15/1404 ,  G01N15/1484 ,  G01N2015/0088 ,  G01N2015/1075 ,  G01N2015/1486 ,  G01N2035/00891

Abstract: An apparatus (10) having scattering and multi-color fluorescence detecting, analyzing and identification capabilities of blood or other fluids of interest. The sample to be tested may be entered in a disposable microfluidic cartridge (14) which in turn is insertable in a hand-holdable or implantable miniaturized and portable cytometer instrument (10). This cytometer (10) has significant application in biological warfare agent detection, hematology and other clinical and research fields.

Abstract translation: 一种具有散射和多色荧光检测，分析和识别血液或其他感兴趣液体的能力的装置（10）。 待测试的样品可以被输入到一次性微流体盒（14）中，该滤芯又可插入可手持式或可植入的小型化和便携式血液计仪器（10）中。 该细胞仪（10）在生物战剂检测，血液学等临床和研究领域具有重要应用。

公开(公告)号：WO2004018967A1

公开(公告)日：2004-03-04

申请号：PCT/US2003/025585

申请日：2003-08-15

Applicant: HONEYWELL INTERNATIONAL INC.

Inventor： FRITZ, Bernard, S. ,  REUTIMAN, Peter ,  PADMANABHAN, Aravind

IPC: G01B11/27

CPC classification number: G01N15/1456 ,  G01B11/272 ,  G01N15/1434 ,  G01N35/085 ,  G01N2015/0069 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0238 ,  G01N2015/1075

Abstract: An optical alignment detection system for detecting the alignment of a first object relative to a second object is provided. One or more light sources and one or more light detectors, either or both of which are secured relative to the second object, are used to detect the position of one or more light scattering elements on the first object.

Abstract translation: 提供了一种用于检测第一物体相对于第二物体的对准的光学对准检测系统。 一个或多个光源和一个或多个光检测器用于检测第一物体上的一个或多个光散射元件的位置，其中一个或两个光检测器相对于第二物体固定。

公开(公告)号：WO2007075922A2

公开(公告)日：2007-07-05

申请号：PCT/US2006/048851

申请日：2006-12-22

Applicant: HONEYWELL INTERNATIONAL INC. ,  REUTIMAN, Peter, L. ,  PADMANABHAN, Aravind ,  COX, James, A. ,  BARDELL, Ron, L. ,  REZACHEK, Tom, M. ,  CABUZ, Cleopatra ,  FRITZ, Bernard, S.

Inventor： REUTIMAN, Peter, L. ,  PADMANABHAN, Aravind ,  COX, James, A. ,  BARDELL, Ron, L. ,  REZACHEK, Tom, M. ,  CABUZ, Cleopatra ,  FRITZ, Bernard, S.

IPC: G01N15/00 ,  G01N15/14 ,  G01N33/49 ,  G01N35/00 ,  G01N35/08

CPC classification number: G01N35/085 ,  G01N15/1056 ,  G01N15/12 ,  G01N15/1459 ,  G01N15/1484 ,  G01N35/00603 ,  G01N35/00663 ,  G01N2015/0069 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1062 ,  G01N2015/1486 ,  G06F19/00

Abstract: A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduced risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.

Abstract translation: 与样本分析仪有关的系统，更具体地说，涉及样本分析仪，该样本分析仪操作简单并且降低了向用户提供错误结果的风险。 在一些情况下，样品分析仪可以是包括一次性流体盒的便携式样品分析仪。 分析仪的操作人员不需要接受培训。

公开(公告)号：WO2007075919A3

公开(公告)日：2007-07-05

申请号：PCT/US2006/048846

申请日：2006-12-22

Applicant: HONEYWELL INTERNATIONAL INC. ,  PADMANABHAN, Aravind ,  COX, James, A. ,  FRITZ, Bernard, S. ,  REZACHEK, Tom, M. ,  REUTIMAN, Peter, N. ,  BARDELL, Ron, L. ,  CABUZ, Cleopatra

Inventor： PADMANABHAN, Aravind ,  COX, James, A. ,  FRITZ, Bernard, S. ,  REZACHEK, Tom, M. ,  REUTIMAN, Peter, N. ,  BARDELL, Ron, L. ,  CABUZ, Cleopatra

IPC: G01N15/14 ,  G01N35/00 ,  B01L3/00

Abstract: A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduced risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable ftuidic cartridge. The operators of the analyzers need not be trained.

公开(公告)号：WO2007005974A3

公开(公告)日：2007-01-11

申请号：PCT/US2006/026212

申请日：2006-06-30

Applicant: HONEYWELL INTERNATIONAL, INC. ,  PADMANABHAN, Aravind ,  CABUZ, Cleopatra

Inventor： PADMANABHAN, Aravind ,  CABUZ, Cleopatra

IPC: B01L3/00 ,  G01N15/14

Abstract: A hematology analyzer or cytometer cartridge system having flow metering. It may have on - or off-cartridge flow metering and control. The system may have local and direct flow measurement to provide accurate counts per unit volume. There may be numerous arrangements for fluidic circuit checks of the cartridge. Examples may include checks pertaining to zero flow, interface, pressure, flow rate, fluid type and quality, backflow, dry qualification, temperature exposure limits, and so on, of the circuits and cartridge associated items.

公开(公告)号：WO2006118586A2

公开(公告)日：2006-11-09

申请号：PCT/US2005/026293

申请日：2005-07-21

Applicant: HONEYWELL INTERNATIONAL INC. ,  PADMANABHAN, Aravind ,  MACFADDEN, Kenneth, O. ,  CABUZ, Cleopatra

Inventor： PADMANABHAN, Aravind ,  MACFADDEN, Kenneth, O. ,  CABUZ, Cleopatra

IPC: B01L3/00

CPC classification number: B41J2/17513 ,  B01L3/502707 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/165 ,  B01L2400/06

Abstract: A microfluidic cartridge that includes at least one reservoir for storing a reagent or the like for an extended period of time. In one illustrative embodiment, at least part of a wall of a reservoir includes a hydrophobic material, such as a polymonochlorotrifluoroethylene (PCTFE) homopolymer and/or copolymer. The hydrophobic material may help reduce leaching, evaporation, diffusion and/or other transfer of the reagent or one of its components from the reservoir. When the reagent or the like is lyophilized, the hydrophobic material may help keep water, water vapor and/or other gases or liquids from entering the reservoir prior to use of the microfluidic cartridge.

Abstract translation: 一种微流体盒，其包括用于长时间存储试剂等的至少一个贮存器。 在一个示例性实施方案中，储存器的壁的至少一部分包括疏水性材料，例如聚单氯三氟乙烯（PCTFE）均聚物和/或共聚物。 疏水性材料可以帮助减少试剂或其一种组分从贮存器的浸出，蒸发，扩散和/或其它转移。 当试剂等被冻干时，在使用微流控盒之前，疏水材料可以帮助保持水，水蒸气和/或其它气体或液体不会进入储存器。

公开(公告)号：WO2007005973A2

公开(公告)日：2007-01-11

申请号：PCT/US2006/026211

申请日：2006-06-30

Applicant: HONEYWELL INTERNATIONAL, INC. ,  COX, James, A. ,  PADMANABHAN, Aravind ,  BARDELL, Ron, L. ,  ZINS, Christopher, J.

Inventor： COX, James, A. ,  PADMANABHAN, Aravind ,  BARDELL, Ron, L. ,  ZINS, Christopher, J.

IPC: B01L3/00 ,  G01N15/14

CPC classification number: G01N15/1459 ,  B01L3/502723 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N15/1404 ,  G01N15/1484 ,  G01N2015/0073 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2015/149

Abstract: A microfluidic circuit cartridge for a complete blood count, including analyses of red blood cells. Various parameters of the red blood cells may be attained. The cartridge may have sphering mechanism which has a channel or loop with a configuration for reducing or eliminating cell settling. The channel or loop may incorporate a combination of straight and curve paths in the context of gravity. The channel may alternatively have a hydrophilic or hydrophobic inside surface. Again alternatively, the channel may have an electro-wettable inside surface. Or, the channel may be subject to an electric or magnetic field. There may also be a mechanism for reducing or eliminating clumping of a sample.

Abstract translation: 用于全血计数的微流体电路盒，包括红细胞分析。 可以获得红细胞的各种参数。 盒可具有球形机构，其具有用于减少或消除细胞沉降的配置的通道或环路。 通道或环路可以在重力环境下结合直线和曲线路径的组合。 该通道可以可选地具有亲水性或疏水性的内表面。 再次可选地，通道可以具有可电润湿的内表面。 或者，频道可能会受到电场或磁场的影响。 也可能有减少或消除样品结块的机制。

公开(公告)号：WO2006124821A1

公开(公告)日：2006-11-23

申请号：PCT/US2006/018809

申请日：2006-05-12

Applicant: HONEYWELL INTERNATIONAL INC. ,  PADMANABHAN, Aravind ,  CLEOPATRA, Cabuz ,  FRITZ, Bernard, S. ,  SCHWICHTENBERG, Jay, G.

Inventor： PADMANABHAN, Aravind ,  CLEOPATRA, Cabuz ,  FRITZ, Bernard, S. ,  SCHWICHTENBERG, Jay, G.

IPC: G01N15/14

CPC classification number: G01N15/1459 ,  B01L3/502715 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0636 ,  B01L2200/0689 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2400/0487 ,  B01L2400/0633 ,  G01N15/1456 ,  G01N15/1484 ,  G01N2015/008 ,  G01N2015/1452 ,  G01N2015/1486

Abstract: A medium having microfluidic circuitry for sampling and analyses. The medium may be a cartridge having a window countersunk into it and containing a flow channel. The flow channel may have items of interest flowing through it. Analyses of these items may be optical involving one or more light sources emanating light to and one or more light detectors receiving light from the channel. There are various configurations so that source and detector light cones may reach the flow channel without obscuration or interference of the light to and from the flow channel in the window.

Abstract translation: 具有用于取样和分析的微流体电路的介质。 该介质可以是具有一个窗口沉入其中并包含流动通道的盒。 流动通道可以具有流过其的兴趣物品。 这些项目的分析可以是光学的，涉及发射光的一个或多个光源和从该通道接收光的一个或多个光检测器。 存在各种配置，使得源和检测器光锥可以到达流动通道而不会使光在窗口中的流动通道的光线不受干扰或干扰。