公开(公告)号：EP2691017B1

公开(公告)日：2016-03-23

申请号：EP12764542.2

申请日：2012-03-29

Applicant: Howard University

Inventor： ANDERSON, John M. M.

IPC: A61B5/026

CPC classification number: A61B6/5217 ,  A61B5/02755 ,  A61B6/037 ,  A61B6/481 ,  A61B6/503 ,  A61B6/507 ,  G06F19/00 ,  G06T7/0016 ,  G06T2207/10104 ,  G06T2207/30104 ,  G16H50/50

Abstract: A myocardial blood flow analysis scan includes incorporating a pharmacological kinetic model with the standard factor analysis model where each time activity curve is assumed to be a linear combination of factor curves. Pharmacological kinetics based factor analysis of dynamic structures (K-FADS) model can be applied, whereby a means for estimating factor curves in the myocardium that are physiologically meaningful is provided. Additional optional aspects include performing a discretization to transform continuous-time K-FADS model into a discretetime K-FADS model and application of an iterative Voxel-Resolution myocardial blood flow (V-MBF) algorithm. A V-MBF algorithm based on a model that accounts for the fact that the shape of TACs due to ischemic and normal tissue are different can be included.

公开(公告)号：EP2691017A2

公开(公告)日：2014-02-05

申请号：EP12764542.2

申请日：2012-03-29

Applicant: Howard University

Inventor： ANDERSON, John M. M.

IPC: A61B5/026

CPC classification number: A61B6/5217 ,  A61B5/02755 ,  A61B6/037 ,  A61B6/481 ,  A61B6/503 ,  A61B6/507 ,  G06F19/00 ,  G06T7/0016 ,  G06T2207/10104 ,  G06T2207/30104 ,  G16H50/50

Abstract: A myocardial blood flow analysis scan includes incorporating a pharmacological kinetic model with the standard factor analysis model where each time activity curve is assumed to be a linear combination of factor curves. Pharmacological kinetics based factor analysis of dynamic structures (K-FADS) model can be applied, whereby a means for estimating factor curves in the myocardium that are physiologically meaningful is provided. Additional optional aspects include performing a discretization to transform continuous-time K-FADS model into a discretetime K-FADS model and application of an iterative Voxel-Resolution myocardial blood flow (V-MBF) algorithm. A V-MBF algorithm based on a model that accounts for the fact that the shape of TACs due to ischemic and normal tissue are different can be included.

公开(公告)号：WO2014130566A1

公开(公告)日：2014-08-28

申请号：PCT/US2014/017185

申请日：2014-02-19

Applicant: HOWARD UNIVERSITY

Inventor： ANDERSON, John M. M. ,  NDOYE, Mandoye

IPC: A61B6/03

CPC classification number: G06T15/08 ,  G01S7/046 ,  G01S7/295 ,  G01S13/003 ,  G01S13/885 ,  G01S13/90

Abstract: A majorize-minimize (MM) mathematical principle is applied to least squares regularization estimation problems to effect efficient processing of image data sets to provide good quality images. In a ground penetrating radar application, these approaches can reduce processing time and memory use by accounting for a symmetric nature of a given radar pulse, accounting for similar discrete time delays between transmission of a given radar pulse and reception of reflections from the given radar pulse, and accounting for a short duration of the given radar pulse.

Abstract translation: 主要最小化（MM）数学原理被应用于最小二乘法正则化估计问题，以实现图像数据集的有效处理，以提供高质量的图像。 在地面穿透雷达应用中，这些方法可以通过考虑给定雷达脉冲的对称性来减少处理时间和存储器使用，考虑给定雷达脉冲的传输和从给定的雷达脉冲接收反射之间的类似的离散时间延迟 ，并且考虑给定雷达脉冲的短时间。

公开(公告)号：WO2012135526A2

公开(公告)日：2012-10-04

申请号：PCT/US2012/031263

申请日：2012-03-29

Applicant: HOWARD UNIVERSITY ,  ANDERSON, John M. M.

Inventor： ANDERSON, John M. M.

IPC: A61B5/026

CPC classification number: A61B6/5217 ,  A61B5/02755 ,  A61B6/037 ,  A61B6/481 ,  A61B6/503 ,  A61B6/507 ,  G06F19/00 ,  G06T7/0016 ,  G06T2207/10104 ,  G06T2207/30104 ,  G16H50/50

Abstract: A myocardial blood flow analysis scan includes incorporating a pharmacological kinetic model with the standard factor analysis model where each time activity curve is assumed to be a linear combination of factor curves. Pharmacological kinetics based factor analysis of dynamic structures (K-FADS) model can be applied, whereby a means for estimating factor curves in the myocardium that are physiologically meaningful is provided. Additional optional aspects include performing a discretization to transform continuous-time K-FADS model into a discretetime K-FADS model and application of an iterative Voxel-Resolution myocardial blood flow (V-MBF) algorithm. A V-MBF algorithm based on a model that accounts for the fact that the shape of TACs due to ischemic and normal tissue are different can be included.

Abstract translation: 心肌血流分析扫描包括将药理动力学模型与标准因子分析模型结合，其中每个活动曲线被假定为因子曲线的线性组合。 可以应用动态结构（K-FADS）模型的药理动力学因子分析，从而提供了一种估计生理学上有意义的心肌因子曲线的方法。 其他可选方面包括执行离散化以将连续时间K-FADS模型变换为离散时间K-FADS模型，并应用迭代体素分辨率心肌血流（V-MBF）算法。 基于模型的V-MBF算法可以包括由于缺血和正常组织导致的TAC形状不同的事实。