公开(公告)号：WO2015035218A1

公开(公告)日：2015-03-12

申请号：PCT/US2014/054367

申请日：2014-09-05

Applicant: HOWARD UNIVERSITY

Inventor： KARLA, Pradeep

IPC: A61K31/00

CPC classification number: A61K31/675 ,  A61K9/0034 ,  A61K9/06 ,  A61K31/47 ,  A61K31/4745 ,  A61K31/4985 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods and compositions are provided for reducing transmission and/or infection of HIV in a subject by increasing the bioavailability of a drug in the subject. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for reducing the transmission and/or infection of HIV in a subject. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).

Abstract translation: 提供了通过增加受试者中药物的生物利用度来减少受试者中HIV的传播和/或感染的方法和组合物。 本文提供的方法和组合物包括外排转运蛋白抑制剂和有效减少受试者中HIV传播和/或感染的药物。 外排转运蛋白抑制剂通过P糖蛋白（Pgp），乳腺癌耐药蛋白（BCRP）和多药耐药相关蛋白1-9（MRP1-9）中的至少一种有效减少药物的流出。