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    POLYLACTIDE AND CALCIUM PHOSPHATE COMPOSITIONS AND METHODS OF MAKING THE SAME
    2.
    发明公开
    POLYLACTIDE AND CALCIUM PHOSPHATE COMPOSITIONS AND METHODS OF MAKING THE SAME 审中-公开
    聚乳酸，磷酸钙组合物及其制备方法

    公开(公告)号：EP2836546A1

    公开(公告)日：2015-02-18

    申请号：EP13775678.9

    申请日：2013-03-08

    Applicant: Howard University

    Inventor： WANG, Tongxin ,  MITCHELL, James W.

    IPC: C08K9/02 ,  C08K9/06

    Abstract: A method is provided for synthesizing PLA/apatite composites with improved mechanical strength. In one aspect, a calcium-phosphate/phosphonate hybrid shell is developed to incorporate more reactive hydroxyl groups onto hydroxyapatite (HA) particles. PLA is covalently bonded to HA calcium phosphate hybrid shell, creating a strong interphase between HA and PLA, thus significantly improve the mechanical strength in comparison to that of non-modified HA.

    Abstract translation: 提供了合成聚丙交酯/磷酸钙复合材料的方法。 在一种形式中，磷酸钙材料用酸质子化，质子化后与硅烷材料结合形成中间体硅烷化磷酸钙材料。 然后将中间体硅烷化磷酸钙材料与丙交酯材料混合以形成聚乳酸/磷酸钙基体材料，该材料的拉伸强度至少为未将硅烷与磷酸钙材料结合制备的聚丙交酯/磷酸钙材料的拉伸强度的1.3倍。

    POLYSACCHARIDE-POLYAMINE COPOLYMERS FOR REMOVAL OF PHOSPHATE
    5.
    发明公开
    POLYSACCHARIDE-POLYAMINE COPOLYMERS FOR REMOVAL OF PHOSPHATE 审中-公开
    多糖 - 多胺共聚物去除磷酸盐

    公开(公告)号：EP3270933A1

    公开(公告)日：2018-01-24

    申请号：EP16769440.5

    申请日：2016-03-18

    Applicant: Howard University

    Inventor： MITCHELL, James W. ,  YANG, Dazhi

    IPC: A61K31/715 ,  A61K31/717 ,  A61K31/738 ,  B01J20/24

    Abstract: Disclosed is a pharmaceutical composition for treating hyperuricemia (HUA). The pharmaceutical composition includes a polysaccharide-polyamine copolymer and a pharmaceutically acceptable salt thereof as active ingredients. The polysaccharide-polyamine copolymer is formed by copolymerization of the following two parts: a selectively oxidized polysaccharide with 2,3-dialdehydo, and a polyamine with an amino functional group; the polyamine with an amino functional group and the selectively oxidized polysaccharide with 2,3-dialdehydo can form a net structure by means of covalent crosslinking, resulting in a hydrogel with an amino functional group or a granular polysaccharide-polyamine copolymer, wherein the amino functional group in the hydrogel with an amino functional group or the granular polysaccharide-polyamine copolymer can be protonated so as to form a cationic copolymer of a three-dimensional network structure having a protonated site, and the nitrogen content of the cationic copolymer and the nitrogen content of the polysaccharide-polyamine copolymer are above 12.3 wt %, and both the cationic copolymer and the polysaccharide-polyamine copolymer are water-insoluble.

    MICROCARRIERS, MATRICES AND SCAFFOLDS FOR CULTURING MAMMALIAN CELLS AND METHODS OF MANUFACTURE
    7.
    发明申请
    MICROCARRIERS, MATRICES AND SCAFFOLDS FOR CULTURING MAMMALIAN CELLS AND METHODS OF MANUFACTURE 审中-公开
    培养MAMMALIAN细胞的微阵列，基质和标准物及其制备方法

    公开(公告)号：WO2016154048A1

    公开(公告)日：2016-09-29

    申请号：PCT/US2016/023248

    申请日：2016-03-18

    Applicant: HOWARD UNIVERSITY

    Inventor： MITCHELL, James W. ,  YANG, Dazhi

    IPC: A61K31/715 ,  A61K31/717 ,  A61K31/738 ,  B01J20/24

    CPC classification number: C08B15/005 ,  C08B15/02 ,  C08B15/06 ,  C08H1/00 ,  C12N5/0075

    Abstract: Microcarriers, matrices and scaffolds for growing mammalian cells are provided which include copolymer particles and matrices comprising of polysaccharide-polyamine copolymers. The copolymeric particles and matrices have a pore size of at least 50 microns and permit the mammalian cells to grow both on an exterior surface of the particles and matrices and within an interior of the particles and matrices. Methods for making such microcarriers, matrices and scaffolds, and compositions are also provided. Methods for growing mammalian cells utilizing such microcarriers, matrices and scaffolds and compositions are also provided.

    Abstract translation: 提供了用于生长哺乳动物细胞的微载体，基质和支架，其包括共聚物颗粒和由多糖 - 多胺共聚物组成的基质。 共聚物颗粒和基质具有至少50微米的孔径，并允许哺乳动物细胞在颗粒和基质的外表面上以及在颗粒和基质内部生长。 还提供了制备这种微载体，基质和支架以及组合物的方法。 还提供了使用这种微载体生长哺乳动物细胞的方法，基质和支架和组合物。

    POLYLACTIDE AND CALCIUM PHOSPHATE COMPOSITIONS AND METHODS OF MAKING THE SAME
    8.
    发明申请
    POLYLACTIDE AND CALCIUM PHOSPHATE COMPOSITIONS AND METHODS OF MAKING THE SAME 审中-公开
    聚合物和磷酸钙组合物及其制备方法

    公开(公告)号：WO2013154705A1

    公开(公告)日：2013-10-17

    申请号：PCT/US2013/029858

    申请日：2013-03-08

    Applicant: HOWARD UNIVERSITY

    Inventor： WANG, Tongxin ,  MITCHELL, James W.

    IPC: C08K9/02 ,  C08K9/06

    CPC classification number: C08K3/32 ,  A61L27/12 ,  A61L27/18 ,  A61L27/58 ,  A61L2430/02 ,  C08K2003/325 ,  C08L67/04

    Abstract: A method is provided for synthesizing polylactide/calcium phosphate composites. In one form, the calcium phosphate material is protonated with an acid and after protonation, combined with a silane material to form an intermediate silanized calcium phosphate material. The intermediate silanized calcium phosphate material is then combined with a lactide material to form the polylactide/ calcium phosphate matrix material that has at least 1.3 times the tensile strength of a polylactide/calcium phosphate material prepared without combining the silane with the calcium phosphate material.

    Abstract translation: 提供了一种合成聚丙交酯/磷酸钙复合材料的方法。 在一种形式中，磷酸钙材料用酸质子化并且在质子化之后，与硅烷材料组合以形成中间体硅烷化磷酸钙材料。 然后将中间硅烷化磷酸钙材料与丙交酯材料组合以形成聚丙交酯/磷酸钙基质材料，其具有在不将硅烷与磷酸钙材料组合的情况下制备的聚丙交酯/磷酸钙材料的拉伸强度的至少1.3倍。

    POLYLACTIDE AND APATITE COMPOSITIONS AND METHODS OF MAKING THE SAME
    9.
    发明申请
    POLYLACTIDE AND APATITE COMPOSITIONS AND METHODS OF MAKING THE SAME 审中-公开
    聚酰胺和APATITE组合物及其制备方法

    公开(公告)号：WO2013154704A1

    公开(公告)日：2013-10-17

    申请号：PCT/US2013/029839

    申请日：2013-03-08

    Applicant: HOWARD UNIVERSITY

    Inventor： WANG, Tongxin ,  MITCHELL, James W.

    IPC: C08G69/14

    CPC classification number: C08K3/32 ,  A61L27/12 ,  A61L27/18 ,  A61L27/58 ,  A61L2430/02 ,  C08K2003/325 ,  C08L67/04

    Abstract: A method is provided for synthesizing PLA/apatite composites with improved mechanical strength. In one aspect, a calcium-phosphate/phosphonate hybrid shell is developed to incorporate more reactive hydroxyl groups onto hydroxyapatite (HA) particles. PLA is covalently bonded to HA calcium phosphate hybrid shell, creating a strong interphase between HA and PLA, thus significantly improve the mechanical strength in comparison to that of non-modified HA.

    Abstract translation: 提供了一种具有改善机械强度的PLA /磷灰石复合材料的合成方法。 在一个方面，开发了磷酸钙/膦酸盐混合物外壳以在羟基磷灰石（HA）颗粒上引入更多的反应性羟基。 PLA与HA磷酸钙混合壳共价结合，在HA和PLA之间形成强相互作用，与非改性HA相比，显着提高机械强度。

    METHODS AND APPARATUS TO CONTROL REACTION RATES OF CHEMICAL REACTIONS BY APPLYING A MAGNETIC FIELD
    10.
    发明申请
    METHODS AND APPARATUS TO CONTROL REACTION RATES OF CHEMICAL REACTIONS BY APPLYING A MAGNETIC FIELD 审中-公开
    通过应用磁场控制化学反应的反应速率的方法和装置

    公开(公告)号：WO2012134954A1

    公开(公告)日：2012-10-04

    申请号：PCT/US2012/030141

    申请日：2012-03-22

    Applicant: HOWARD UNIVERSITY ,  LITTLE, Reginald B. ,  MITCHELL, James W.

    Inventor： LITTLE, Reginald B. ,  MITCHELL, James W.

    IPC: B01J8/02

    CPC classification number: B01J19/087 ,  B01J2219/089 ,  B01J2219/0892 ,  B82Y30/00 ,  B82Y40/00 ,  C01B31/043 ,  C01B31/0484 ,  C01B32/194 ,  C01B32/23

    Abstract: Methods and apparatus to control reaction rates of chemical reactions. Methods can include mixing chemical reactants to provide a reaction mixture, at least one chemical reactant being magnetic; and applying a magnetic field to the reaction mixture, the magnetic field being applied to effect a control of the rate of a chemical reaction between the reactants in the reaction mixture, the magnetic field being effective to change the reaction rate over a chemical reaction between the same reactants at the same pressure and temperature where the reaction mixture is not exposed to the magnetic field.

    Abstract translation: 控制化学反应速率的方法和装置。 方法可以包括混合化学反应物以提供反应混合物，至少一种化学反应物是磁性的; 并且向反应混合物施加磁场，施加磁场以控制反应混合物中反应物之间的化学反应速率，该磁场有效地改变反应速率之间的化学反应 相同的反应物在相同的压力和温度下反应混合物不暴露于磁场。

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