METHOD FOR PRODUCING HUMAN EPIDERMAL GROWTH FACTOR IN LARGE VOLUME FROM YEAST
    4.
    发明申请
    METHOD FOR PRODUCING HUMAN EPIDERMAL GROWTH FACTOR IN LARGE VOLUME FROM YEAST 有权
    从日本大批量生产人类生殖生长因子的方法

    公开(公告)号:US20130323785A1

    公开(公告)日:2013-12-05

    申请号:US13883264

    申请日:2011-11-04

    CPC classification number: C07K14/485 C12N15/81 C12R1/645

    Abstract: The present invention relates to a method for producing hEGF (human epidermal growth factor) which has the same activity as the wild form, in high concentration and with a high degree of purity. More specifically, the invention relates to an hEGF expression vector comprising a nucleic acid sequence coding for the polypeptide of sequence number 14; a host cell in which the expression vector has been genetically transformed; and a method for producing hEGF, comprising a step in which the expression vector is created and is genetically transformed in yeast from which the KEX1 gene is lacking. Using the method of the present invention, it is possible to produce a large volume of human derived EGF which has the same size and activity as human derived EGF, and this EGF can be used in various ways such as in medicine and cosmetics.

    Abstract translation: 本发明涉及以高浓度和高纯度生产具有与野生型相同的活性的hEGF(人表皮生长因子)的方法。 更具体地,本发明涉及包含编码序列号14的多肽的核酸序列的hEGF表达载体; 其中表达载体已被遗传转化的宿主细胞; 以及生产hEGF的方法,包括其中缺少表达载体并在KEX1基因缺失的酵母中遗传转化的步骤。 使用本发明的方法,可以生产与人源性EGF具有相同大小和活性的大量人源性EGF,并且该EGF可以以各种方式用于医药和化妆品中。

    COMPOSITION FOR USE IN GOLF BALLS AND SPORTS EQUIPMENT
    9.
    发明申请
    COMPOSITION FOR USE IN GOLF BALLS AND SPORTS EQUIPMENT 有权
    用于高尔夫球和体育设备的组合物

    公开(公告)号:US20100298066A1

    公开(公告)日:2010-11-25

    申请号:US12823002

    申请日:2010-06-24

    Applicant: Hyun Jin Kim

    Inventor: Hyun Jin Kim

    CPC classification number: C08F8/30 C08F8/44 C08F210/02

    Abstract: Disclosed embodiments involve a novel blend composition for use in sports equipment, particularly for use in golf ball manufacture. The composition comprises three components, (A), (B), and (C). Component (A) can be selected from polymer(s) comprising an ethylene moiety and one or more unsaturated carboxylic acid, sulfonic acid, or phosphoric acid groups. Component (B) is a compound having a formula (R2N)m—R′—(X(O)nORy)m and component (C) is a basic metal ion salt having the ability to neutralize some, or all of the acidic groups present in components (A) and (B). The blend composition can also comprise an additional polymer and/or the reaction product of one or more ionomers and component (B). In particular embodiments, the blend composition is used in golf balls, comprising a core; an outer cover layer; and 0-5 intermediate layers; wherein one or more of said core, outer cover, and/or intermediate layers, if present, includes the blend composition.

    Abstract translation: 公开的实施方案涉及用于运动设备中的新型混合组合物,特别用于高尔夫球制造中。 组合物包含(A),(B)和(C)三种组分。 组分(A)可以选自包含乙烯部分和一个或多个不饱和羧酸,磺酸或磷酸基团的聚合物。 组分(B)是具有式(R2N)m -R' - (X(O)nOR y)m的化合物,组分(C)是具有中和一些或全部酸性基团的能力的碱性金属离子盐 存在于组分(A)和(B)中。 共混组合物还可以包含另外的聚合物和/或一种或多种离聚物和组分(B)的反应产物。 在具体实施方案中,共混组合物用于包括芯的高尔夫球; 外覆盖层; 和0-5个中间层; 其中所述芯,外覆盖层和/或中间层(如果存在)中的一个或多个包括所述共混组合物。

    Patient-specific hemodynamics of the cardio vascular system
    10.
    发明申请
    Patient-specific hemodynamics of the cardio vascular system 有权
    心血管系统的患者特异性血液动力学

    公开(公告)号:US20100241404A1

    公开(公告)日:2010-09-23

    申请号:US12661491

    申请日:2010-03-17

    CPC classification number: G06F19/3437 G06F19/00 G06F19/321 G16H10/60 G16H50/50

    Abstract: A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies.

    Abstract translation: 提供非侵入性患者特异性方法来帮助分析,诊断,预测或治疗患者心血管系统的血液动力学。 可以使用与至少一部分剩余心血管系统的模型隐含耦合的基于3-D患者图像的模型来预测冠状动脉血流和压力。 3-D患者基于图像的模型包括患者的胸主动脉和心外膜冠状动脉的至少一部分。 模型界面处的一个或多个速度分布的形状被强制以控制循环或逆行流的复杂流动特征,从而最小化模型不稳定性,并导致患者对冠状动脉血流速率和压力的预测。 本发明允许患者特异性预测冠状动脉介入治疗,经皮冠状动脉介入治疗和手术治疗的不同或不同生理状态和血液动力学益处的影响。

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