公开(公告)号：GB2510484B

公开(公告)日：2019-08-28

申请号：GB201322168

申请日：2012-05-14

Applicant: IBM

Inventor： AJAY K ROYYURU

IPC: G01N33/487

Abstract: A molecular dispenser includes a molecular reservoir comprising a plurality of charged molecules; a nanopore proximate the molecular reservoir, the nanopore comprising a first set of locking electrodes configured to establish an electrostatic potential barrier therein and a second set of locking electrodes configured to establish a second electrostatic potential barrier therein; a first drag electrode arranged within the molecular reservoir; and a control unit, wherein the control unit is configured to apply an oscillating voltage across the first set of locking electrodes and a bias voltage to the first drag electrode to control flow of individually charged molecules from the molecular reservoir through the nanopore.

公开(公告)号：GB2519904B

公开(公告)日：2018-12-19

申请号：GB201503531

申请日：2013-08-14

Applicant: IBM

Inventor： AJAY K ROYYURU ,  CHAO WANG

IPC: G01N33/487 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N27/414

公开(公告)号：GB2561269A

公开(公告)日：2018-10-10

申请号：GB201716240

申请日：2016-03-21

Applicant: IBM

Inventor： BOAZ CARMELI ,  BILAL ERHAN ,  TAKAHIKO KOYAMA ,  KHAN RHRISSORRAKRAI ,  AJAY K ROYYURU ,  FILIPPO UTRO ,  ZEEV WAKS

IPC: G06F19/12 ,  G16B45/00 ,  G16H50/20 ,  G16H50/50

Abstract: A computer implemented method of assessing a relevancy of a pathway to a disease of interest, the pathway having a source and a target. The method includes developing an impact of the source on the pathway. The method further includes developing a value of targeting, based at least in part on an alteration of the pathway, the pathway with a drug of interest. The method further includes identifying a relationship between the source and the target within the pathway. The method further includes combining: the impact of the source on the pathway; the value of targeting, based at least in part on the alteration of the pathway, the pathway with a drug of interest; and the relationship between the source and the target within the pathway, wherein the combining results in an assessment that represents the relevancy of the pathway to the disease of interest.